Volume 46, Issue 1 pp. 167-174

Technical Development

Multishot cartesian turbo spin-echo diffusion imaging using iterative POCSMUSE Reconstruction

Zhe Zhang BS,

Zhe Zhang BS

Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China

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Bing Zhang MD,

Bing Zhang MD

Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

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Ming Li MD,

Ming Li MD

Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

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Xue Liang MD,

Xue Liang MD

Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

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Xiaodong Chen MD, PhD,

Xiaodong Chen MD, PhD

Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China

Department of Radiology, Affiliated Hospital of Guangdong Medical College, Guangdong, China

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Renyuan Liu MD,

Renyuan Liu MD

Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

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Xin Zhang MD,

Xin Zhang MD

Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

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Hua Guo PhD,

Corresponding Author

Hua Guo PhD

[email protected]

Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China

Address reprint requests to: H.G., Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China. E-mail: [email protected]Search for more papers by this author

Zhe Zhang BS,

Zhe Zhang BS

Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China

Search for more papers by this author

Bing Zhang MD,

Bing Zhang MD

Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

Search for more papers by this author

Ming Li MD,

Ming Li MD

Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

Search for more papers by this author

Xue Liang MD,

Xue Liang MD

Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

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Xiaodong Chen MD, PhD,

Xiaodong Chen MD, PhD

Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China

Department of Radiology, Affiliated Hospital of Guangdong Medical College, Guangdong, China

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Renyuan Liu MD,

Renyuan Liu MD

Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

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Xin Zhang MD,

Xin Zhang MD

Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

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Hua Guo PhD,

Corresponding Author

Hua Guo PhD

[email protected]

Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China

First published: 20 October 2016

https://doi.org/10.1002/jmri.25522

Citations: 12

This article was published online October 20, 2016. After online publication, the spelling of the word “multishot” was corrected throughout the article. This notice is included to indicate that it has been corrected on 28 October, 2016.

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Abstract

Purpose

To report a diffusion imaging technique insensitive to off-resonance artifacts and motion-induced ghost artifacts using multishot Cartesian turbo spin-echo (TSE) acquisition and iterative POCS-based reconstruction of multiplexed sensitivity encoded magnetic resonance imaging (MRI) (POCSMUSE) for phase correction.

Materials and Methods

Phase insensitive diffusion preparation was used to deal with the violation of the Carr–Purcell–Meiboom–Gill (CPMG) conditions of TSE diffusion-weighted imaging (DWI), followed by a multishot Cartesian TSE readout for data acquisition. An iterative diffusion phase correction method, iterative POCSMUSE, was developed and implemented to eliminate the ghost artifacts in multishot TSE DWI. The in vivo human brain diffusion images (from one healthy volunteer and 10 patients) using multishot Cartesian TSE were acquired at 3T and reconstructed using iterative POCSMUSE, and compared with single-shot and multishot echo-planar imaging (EPI) results. These images were evaluated by two radiologists using visual scores (considering both image quality and distortion levels) from 1 to 5.

Results

The proposed iterative POCSMUSE reconstruction was able to correct the ghost artifacts in multishot DWI. The ghost-to-signal ratio of TSE DWI using iterative POCSMUSE (0.0174 ± 0.0024) was significantly (P < 0.0005) smaller than using POCSMUSE (0.0253 ± 0.0040). The image scores of multishot TSE DWI were significantly higher than single-shot (P = 0.004 and 0.006 from two reviewers) and multishot (P = 0.008 and 0.004 from two reviewers) EPI-based methods.

Conclusion

The proposed multishot Cartesian TSE DWI using iterative POCSMUSE reconstruction can provide high-quality diffusion images insensitive to motion-induced ghost artifacts and off-resonance related artifacts such as chemical shifts and susceptibility-induced image distortions.

Level of Evidence: 1

Technical Efficacy: Stage 1

J. MAGN. RESON. IMAGING 2017;46:167–174

Supporting Information

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Volume46, Issue1

July 2017

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Multishot cartesian turbo spin-echo diffusion imaging using iterative POCSMUSE Reconstruction

Abstract

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Materials and Methods

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Conclusion

Supporting Information

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Multishot cartesian turbo spin-echo diffusion imaging using iterative POCSMUSE Reconstruction

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