Diffusion kurtosis imaging predicts neoadjuvant chemotherapy responses within 4 days in advanced nasopharyngeal carcinoma patients
Corresponding Author
Yunbin Chen MD
Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
Department of Radiology, First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China
The first two authors contributed equally to this work.
Address reprint requests to: Y.C., No. 420, Fuma Road, Fuzhou, Fujian, P.R. China 350014. E-mail: [email protected].Search for more papers by this authorWang Ren MS
Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
The first two authors contributed equally to this work.
Search for more papers by this authorDechun Zheng MS
Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
Department of Radiology, First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorJing Zhong MS
Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorXiangyi Liu MS
Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorQiuyuan Yue MS
Department of Radiology, First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorMeng Liu MS
Department of Radiology, First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorYouping Xiao MS
Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorWeibo Chen PhD
Philips Healthcare, Shanghai, People's Republic of China
Search for more papers by this authorQueenie Chan PhD
Philips Healthcare, Hong Kong, People's Republic of China
Search for more papers by this authorJianji Pan MD
Department of Radiation Oncology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorCorresponding Author
Yunbin Chen MD
Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
Department of Radiology, First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China
The first two authors contributed equally to this work.
Address reprint requests to: Y.C., No. 420, Fuma Road, Fuzhou, Fujian, P.R. China 350014. E-mail: [email protected].Search for more papers by this authorWang Ren MS
Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
The first two authors contributed equally to this work.
Search for more papers by this authorDechun Zheng MS
Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
Department of Radiology, First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorJing Zhong MS
Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorXiangyi Liu MS
Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorQiuyuan Yue MS
Department of Radiology, First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorMeng Liu MS
Department of Radiology, First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorYouping Xiao MS
Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorWeibo Chen PhD
Philips Healthcare, Shanghai, People's Republic of China
Search for more papers by this authorQueenie Chan PhD
Philips Healthcare, Hong Kong, People's Republic of China
Search for more papers by this authorJianji Pan MD
Department of Radiation Oncology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China
Search for more papers by this authorAbstract
Purpose
To explore the clinical value of diffusion kurtosis imaging (DKI) and monoexponential diffusion-weighted imaging (DWI) for predicting early response to neoadjuvant chemotherapy (NAC) in patients with nasopharyngeal carcinoma (NPC).
Materials and Methods
Fifty-nine patients with stage III-IVb NPC underwent four 3.0T MR scans: prior to, and on the 4th, 21st, 42nd days after NAC initiation. The parameters of DKI (corrected diffusion coefficient, D; excess diffusion kurtosis coefficient, K) and monoexponential DWI (apparent diffusion coefficient, ADC) were obtained at the first three scans. Statistical methods included Student's t-test or Mann-Whitney U-test, receiver operating characteristic (ROC) curve analyses and paired X2 test.
Results
D(pre) in responders group (RG) was significantly lower than nonresponders group (NRG) (1.029 ± 0.033 vs. 1.184 ± 0.055, ×10−3 mm2/s, P = 0.020). ADC(day4) and ΔD(day4) were the most useful parameters of the two diffusional models to distinguish RG from NRG, respectively (area under the curve, 0.761 vs. 0.895). ΔD(day4) was more sensitive than ADC(day4) to predict treatment response to NAC (P = 0.006).
Conclusion
Both DKI and monoexponential DWI showed potential to predict treatment response to NAC prior to morphological change. DKI may be superior to monoexponential DWI for predicting early response to NAC in patients with locally advanced NPC. J. Magn. Reson. Imaging 2015;42:1354–1361.
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