T1 mapping in the rat myocardium at 7 tesla using a modified CINE inversion recovery sequence
Corresponding Author
Henk Smit MSc
Departments of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands
Address reprint requests to: H.S., P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. E-mail: [email protected]Search for more papers by this authorRuben Pellicer Guridi MSc
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Search for more papers by this authorJamal Guenoun MD
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Search for more papers by this authorDirk H. J. Poot PhD
Departments of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands
Search for more papers by this authorGabriela N. Doeswijk BSc
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Search for more papers by this authorMatteo Milanesi PhD
Agilent Technologies Inc, Yarnton, Oxford, United Kingdom
Search for more papers by this authorMonique R. Bernsen PhD
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Department of Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands
Search for more papers by this authorGabriel P. Krestin PhD
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Search for more papers by this authorStefan Klein PhD
Departments of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands
Search for more papers by this authorGyula Kotek PhD
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Search for more papers by this authorCorresponding Author
Henk Smit MSc
Departments of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands
Address reprint requests to: H.S., P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. E-mail: [email protected]Search for more papers by this authorRuben Pellicer Guridi MSc
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Search for more papers by this authorJamal Guenoun MD
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Search for more papers by this authorDirk H. J. Poot PhD
Departments of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands
Search for more papers by this authorGabriela N. Doeswijk BSc
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Search for more papers by this authorMatteo Milanesi PhD
Agilent Technologies Inc, Yarnton, Oxford, United Kingdom
Search for more papers by this authorMonique R. Bernsen PhD
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Department of Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands
Search for more papers by this authorGabriel P. Krestin PhD
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Search for more papers by this authorStefan Klein PhD
Departments of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands
Search for more papers by this authorGyula Kotek PhD
Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
Search for more papers by this authorAbstract
Purpose
To evaluate the reproducibility and sensitivity of the modified CINE inversion recovery (mCINE-IR) acquisition on rats for measuring the myocardial T1 at 7 Tesla.
Materials and Methods
The recently published mCINE-IR acquisition on humans was applied on rats for the first time, enabling the possibility of translational studies with an identical sequence. Simulations were used to study signal evolution and heart rate dependency. Gadolinium phantoms, a heart specimen and a healthy rat were used to study reproducibility. Two cryo-infarcted rats were scanned to measure late gadolinium enhancement (LGE).
Results
In the phantom reproducibility studies the T1 measurements had a maximum coefficient of variation (COV) of 1.3%. For the in vivo reproducibility the COV was below 5% in the anterior cardiac segments. In simulations with phantoms and specimens, a heart rate dependency of approximately 0.5 ms/bpm was present. The T1 maps of the cryo-infarcted rats showed a clear lowering of T1 in de LGE region.
Conclusion
The results show that mCINE-IR is highly reproducible and that the sensitivity allows detecting T1 changes in the rat myocardium. J. Magn. Reson. Imaging 2014;39:901–910. © 2013 Wiley Periodicals, Inc.
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