Value of diffusion-weighted MR imaging performed with quantitative apparent diffusion coefficient values for cervical lymphadenopathy
Lian-Ming Wu MD, PhD
Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorCorresponding Author
Jian-Rong Xu MD, PhD
Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Address reprint requests to: J.-R.X., Professor, Department of Radiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, No. 1630, Dongfang Road, Pudong, Shanghai 200127, China. E-mail: [email protected]Search for more papers by this authorJia Hua MD
Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorHai-Yan Gu MD
Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorJiong Zhu MD, PhD
Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorJiani Hu MD, PhD
Department of Radiology, Wayne State University, 48201 Detroit, Michigan, USA
Search for more papers by this authorLian-Ming Wu MD, PhD
Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorCorresponding Author
Jian-Rong Xu MD, PhD
Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Address reprint requests to: J.-R.X., Professor, Department of Radiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, No. 1630, Dongfang Road, Pudong, Shanghai 200127, China. E-mail: [email protected]Search for more papers by this authorJia Hua MD
Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorHai-Yan Gu MD
Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorJiong Zhu MD, PhD
Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorJiani Hu MD, PhD
Department of Radiology, Wayne State University, 48201 Detroit, Michigan, USA
Search for more papers by this authorAbstract
Purpose
To assess diffusion-weighted magnetic resonance imaging (DWI-MRI) performed with apparent diffusion coefficient (ADC) values for the detection of cervical lymphadenopathy.
Materials and Methods
Studies evaluating DWI-MRI for the detection of cervical lymphadenopathy were systematically searched for in the MEDLINE, EMBASE, Cancerlit, and Cochrane Library and other database from January 1995 to November 2010. By node-based data analyses, Cochrane methodology was used for the results of this meta-analysis.
Results
Eight studies enrolling a total of 229 individuals were eligible for inclusion. Significant differences were found between malignant nodes and benign nodes of the mean ADC value (WMD [weighted-mean difference]: 1.19, 95% CI: [1.02, 1.35] × 10−3 mm2/s, [P < 0.05]). In the secondary outcomes, significant differences were found between lymphomatous nodes and benign nodes (WMD: 1.33, 95% CI: [0.89, 1.77] × 10−3 mm2/s), and nodes originating from highly or moderately differentiated cancer (WMD: 0.24, 95% CI: [0.21, 0.28] × 10−3 mm2/s, [P < 0.05]), and nodes originating from poorly differentiated cancers (WMD: 0.10, 95% CI: [0.06, 0.14] × 10−3 mm2/s, [P < 0.05]).
Conclusion
DWI-MRI performed with ADC values shows significant differences among malignant nodes, lymphomatous nodes, and benign nodes in cervical lymphadenopathy. J. Magn. Reson. Imaging 2012;38:663–670. © 2012 Wiley Periodicals, Inc.
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