Vascular space occupancy-dependent functional MRI by tissue suppression†
Changwei W. Wu MS
Interdisciplinary MRI/MRS Lab, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
Search for more papers by this authorKai-Hsiang Chuang PhD
Laboratory of Molecular Imgaging, Singapore Bioimaging Consortium, Helios, Singapore
Search for more papers by this authorYau-Yau Wai MD
Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kweishan, Taiwan
MRI Center, Chang Gung Memorial Hospital, Kweishan, Taiwan
Search for more papers by this authorYung-Liang Wan MD
Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kweishan, Taiwan
MRI Center, Chang Gung Memorial Hospital, Kweishan, Taiwan
Search for more papers by this authorCorresponding Author
Jyh-Horng Chen PhD
Interdisciplinary MRI/MRS Lab, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
Jyh-Horng Chen, Department of Electrical Engineering, National Taiwan University, Sect. 4, No. 1, Roosevelt Rd., Taipei 106, Taiwan
Ho-Ling Liu, MRI Center, Chang Gung Memorial Hospital, 5 Fuhsing St., Kweishan, Taoyuan 333, Taiwan
Search for more papers by this authorCorresponding Author
Ho-Ling Liu PhD
Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kweishan, Taiwan
MRI Center, Chang Gung Memorial Hospital, Kweishan, Taiwan
Jyh-Horng Chen, Department of Electrical Engineering, National Taiwan University, Sect. 4, No. 1, Roosevelt Rd., Taipei 106, Taiwan
Ho-Ling Liu, MRI Center, Chang Gung Memorial Hospital, 5 Fuhsing St., Kweishan, Taoyuan 333, Taiwan
Search for more papers by this authorChangwei W. Wu MS
Interdisciplinary MRI/MRS Lab, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
Search for more papers by this authorKai-Hsiang Chuang PhD
Laboratory of Molecular Imgaging, Singapore Bioimaging Consortium, Helios, Singapore
Search for more papers by this authorYau-Yau Wai MD
Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kweishan, Taiwan
MRI Center, Chang Gung Memorial Hospital, Kweishan, Taiwan
Search for more papers by this authorYung-Liang Wan MD
Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kweishan, Taiwan
MRI Center, Chang Gung Memorial Hospital, Kweishan, Taiwan
Search for more papers by this authorCorresponding Author
Jyh-Horng Chen PhD
Interdisciplinary MRI/MRS Lab, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
Jyh-Horng Chen, Department of Electrical Engineering, National Taiwan University, Sect. 4, No. 1, Roosevelt Rd., Taipei 106, Taiwan
Ho-Ling Liu, MRI Center, Chang Gung Memorial Hospital, 5 Fuhsing St., Kweishan, Taoyuan 333, Taiwan
Search for more papers by this authorCorresponding Author
Ho-Ling Liu PhD
Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kweishan, Taiwan
MRI Center, Chang Gung Memorial Hospital, Kweishan, Taiwan
Jyh-Horng Chen, Department of Electrical Engineering, National Taiwan University, Sect. 4, No. 1, Roosevelt Rd., Taipei 106, Taiwan
Ho-Ling Liu, MRI Center, Chang Gung Memorial Hospital, 5 Fuhsing St., Kweishan, Taoyuan 333, Taiwan
Search for more papers by this authorPart of this work was presented at the 12th Annual Meeting of International Society of Magnetic Resonance in Medicine, Kyoto, Japan, 2004.
Abstract
Purpose
To measure the cerebral blood volume (CBV) dynamics during neural activation, a novel technique named vascular space occupancy (VASO)-based functional MRI (fMRI) was recently introduced for noninvasive CBV detection. However, its application is limited because of its low contrast-to-noise ratio (CNR) due to small signal change from the inverted blood.
Materials and Methods
In this study a new approach—VASO with tissue suppression (VAST)—is proposed to enhance CNR. This technique is compared with VASO and blood oxygenation level-dependent (BOLD) fMRI in block-design and event-related visual experiments.
Results
Based on acquired T1 maps, 75.3% of the activated pixels detected by VAST are located in the cortical gray matter. Temporal characteristics of functional responses obtained by VAST were consistent with that of VASO. Although the baseline signal was decreased by the tissue suppression, the CNR of VAST was about 43% higher than VASO.
Conclusion
With the improved sensitivity, VAST fMRI provides a useful alternative for mapping the spatial/temporal features of regional CBV changes during brain activation. However, the technical imperfectness of VAST, such as the nonideal inversion efficiency and physiological contaminations, limits its application to precise CBV quantification. J. Magn. Reson. Imaging 2008;28:219–226. © 2008 Wiley-Liss, Inc.
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