Image-based musculoskeletal modeling: Applications, advances, and future opportunities
Corresponding Author
Silvia S. Blemker PhD
Department of Mechanical & Aerospace Engineering, University of Virginia, Charlottesville, Virginia, USA
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
Department of Mechanical & Aerospace Engineering, University of Virginia, 122 Engineer's Way, P.O. Box 400746, Charlottesville, Virginia 22904-4746Search for more papers by this authorDeanna S. Asakawa PhD
Department of Bioengineering, Stanford University, Stanford, California, USA
Search for more papers by this authorGarry E. Gold MD
Department of Radiology, Stanford University, Stanford, California, USA
Search for more papers by this authorScott L. Delp PhD
Department of Bioengineering, Stanford University, Stanford, California, USA
Department of Mechanical Engineering, Stanford University, Stanford, California, USA
Search for more papers by this authorCorresponding Author
Silvia S. Blemker PhD
Department of Mechanical & Aerospace Engineering, University of Virginia, Charlottesville, Virginia, USA
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
Department of Mechanical & Aerospace Engineering, University of Virginia, 122 Engineer's Way, P.O. Box 400746, Charlottesville, Virginia 22904-4746Search for more papers by this authorDeanna S. Asakawa PhD
Department of Bioengineering, Stanford University, Stanford, California, USA
Search for more papers by this authorGarry E. Gold MD
Department of Radiology, Stanford University, Stanford, California, USA
Search for more papers by this authorScott L. Delp PhD
Department of Bioengineering, Stanford University, Stanford, California, USA
Department of Mechanical Engineering, Stanford University, Stanford, California, USA
Search for more papers by this authorAbstract
Computer models of the musculoskeletal system are broadly used to study the mechanisms of musculoskeletal disorders and to simulate surgical treatments. Musculoskeletal models have historically been created based on data derived in anatomical and biomechanical studies of cadaveric specimens. MRI offers an abundance of novel methods for acquisition of data from living subjects and is revolutionizing the field of musculoskeletal modeling. The need to create accurate, individualized models of the musculoskeletal system is driving advances in MRI techniques including static imaging, dynamic imaging, diffusion imaging, body imaging, pulse-sequence design, and coil design. These techniques apply to imaging musculoskeletal anatomy, muscle architecture, joint motions, muscle moment arms, and muscle tissue deformations. Further advancements in image-based musculoskeletal modeling will expand the accuracy and utility of models used to study musculoskeletal and neuromuscular impairments. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc.
REFERENCES
- 1 Neilson PD, O'Dwyer NJ, Nash J. Control of isometric muscle activity in cerebral palsy. Dev Med Child Neurol 1990; 32: 778–788.
- 2 Gage JR. Gait analysis in cerebral palsy. London: Mac Keith Press; 1991; 221p.
- 3 Tardieu G, Tardieu C. Cerebral palsy. Mechanical evaluation and conservative correction of limb joint contractures. Clin Orthop Relat Res 1987; 219: 63–69.
- 4 Laplaza FJ, Root L, Tassanawipas A, Glasser DB. Femoral torsion and neck-shaft angles in cerebral palsy. J Pediatr Orthop 1993; 13: 192–199.
- 5 Cornell MS. The hip in cerebral palsy. Dev Med Child Neurol 1995; 37: 3–18.
- 6 Brand RA, Pedersen DR. Computer modeling of surgery and a consideration of the mechanical effects of proximal femoral osteotomies. St. Louis: Mosby; 1984. p 193–210.
- 7 Schmidt DJ, Arnold AS, Carroll NC, Delp SL. Length changes of the hamstrings and adductors resulting from derotational osteotomies of the femur. J Orthop Res 1999; 17: 279–285.
- 8 Lieber RL, Friden J. Intraoperative measurement and biomechanical modeling of the flexor carpi ulnaris-to-extensor carpi radialis longus tendon transfer. J Biomech Eng 1997; 119: 386–391.
- 9 Murray WM, Bryden AM, Kilgore KL, Keith MW. The influence of elbow position on the range of motion of the wrist following transfer of the brachioradialis to the extensor carpi radialis brevis tendon. J Bone Joint Surg Am 2002; 84-A: 2203–2210.
- 10 Herrmann AM, Delp SL. Moment arm and force-generating capacity of the extensor carpi ulnaris after transfer to the extensor carpi radialis brevis. J Hand Surg (Am) 1999; 24: 1083–1090.
- 11 Delp SL, Ringwelski DA, Carroll NC. Transfer of the rectus femoris: effects of transfer site on moment arms about the knee and hip. J Biomech 1994; 27: 1201–1211.
- 12 Delp SL, Statler K, Carroll NC. Preserving plantar flexion strength after surgical treatment for contracture of the triceps surae: a computer simulation study. J Orthop Res 1995; 13: 96–104.
- 13 Delp SL, Zajac FE. Force- and moment-generating capacity of lower-extremity muscles before and after tendon lengthening. Clin Orthop 1992; 284: 247–259.
- 14 Delp SL, Komattu AV, Wixson RL. Superior displacement of the hip in total joint replacement: effects of prosthetic neck length, neck-stem angle, and anteversion angle on the moment-generating capacity of the muscles. J Orthop Res 1994; 12: 860–870.
- 15 Delp SL, Wixson RL, Komattu AV, Kocmond JH. How superior placement of the joint center in hip arthroplasty affects the abductor muscles. Clin Orthop 1996; 328: 137–146.
- 16 Piazza SJ, Delp SL. Three-dimensional dynamic simulation of total knee replacement motion during a step-up task. J Biomech Eng 2001; 123: 599–606.
- 17 Anderson FC, Pandy MG. Individual muscle contributions to support in normal walking. Gait Posture 2003; 17: 159–169.
- 18 Piazza SJ, Delp SL. The influence of muscles on knee flexion during the swing phase of gait. J Biomech 1996; 29: 723–733.
- 19 Delp SL, Loan JP, Hoy MG, Zajac FE, Topp EL, Rosen JM. An interactive graphics-based model of the lower extremity to study orthopaedic surgical procedures. IEEE Trans Biomed Eng 1990; 37: 757–767.
- 20 Zajac FE. Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. Crit Rev Biomed Eng 1989; 17: 359–411.
- 21 Pappas GP, Asakawa DS, Delp SL, Zajac FE, Drace JE. Nonuniform shortening in the biceps brachii during elbow flexion. J Appl Physiol 2002; 92: 2381–2389.
- 22 Blemker SS, Pinsky PM, Delp SL. A 3D model of muscle reveals the causes of nonuniform strains in the biceps brachii. J Biomech 2005; 38: 657–665.
- 23 Higginson JS, Zajac FE, Neptune RR, Kautz SA, Delp SL. Muscle contributions to support during gait in an individual with post-stroke hemiparesis. J Biomech 2006; 39: 1769–1777.
- 24 To CS, Kirsch RF, Kobetic R, Triolo RJ. Simulation of a functional neuromuscular stimulation powered mechanical gait orthosis with coordinated joint locking. IEEE Trans Neural Syst Rehabil Eng 2005; 13: 227–235.
- 25 Paul C, Bellotti M, Jezernik S, Curt A. Development of a human neuro-musculo-skeletal model for investigation of spinal cord injury. Biol Cybern 2005; 93: 153–170.
- 26 Gill HS, O'Connor JJ. Heelstrike and the pathomechanics of osteoarthrosis: a simulation study. J Biomech 2003; 36: 1617–1624.
- 27 McLean SG, Su A, van den Bogert AJ. Development and validation of a 3-D model to predict knee joint loading during dynamic movement. J Biomech Eng 2003; 125: 864–874.
- 28 Manal K, Buchanan TS. Use of an EMG-driven biomechanical model to study virtual injuries. Med Sci Sports Exerc 2005; 37: 1917–1923.
- 29 Fleming BC, Beynnon BD. In vivo measurement of ligament/tendon strains and forces: a review. Ann Biomed Eng 2004; 32: 318–328.
- 30 Gold GE, McCauley TR, Gray ML, Disler DG. What's new in cartilage? Radiographics 2003; 23: 1227–1242.
- 31 Lang P, Noorbakhsh F, Yoshioka H. MR imaging of articular cartilage: current state and recent developments. Radiol Clin North Am 2005; 43: 629–639, vii.
- 32 White LM, Kramer J, Recht MP. MR imaging evaluation of the postoperative knee: ligaments, menisci, and articular cartilage. Skeletal Radiol 2005; 34: 431–452.
- 33 Delp SL, Loan JP. A computational framework for simulation and analysis of human and animal movement. IEEE Comput Sci Engr 2000; 2: 46–55.
- 34 Buford WL, Ivey FM, Malone JD, et al. Muscle balance at the knee—moment arms for the normal knee and the ACL-minus knee. IEEE Trans Rehabil Eng 1997; 5: 367–379.
- 35 Murray WM, Delp SL, Buchanan TS. Variation of muscle moment arms with elbow and forearm position. J Biomech 1995; 28: 513–525.
- 36 Nemeth G, Ekholm J, Arborelius UP, Harms-Ringdahl K, Schuldt K. Influence of knee flexion on isometric hip extensor strength. Scand J Rehabil Med 1983; 15: 97–101.
- 37 Buchanan TS, Delp SL, Solbeck JA. Muscular resistance to varus and valgus loads at the elbow. J Biomech Eng 1998; 120: 634–639.
- 38 Blemker SS, Delp SL. Three-dimensional representation of complex muscle architectures and geometries. Ann Biomed Eng 2005; 33: 661–673.
- 39 Arnold AS, Salinas S, Asakawa DJ, Delp SL. Accuracy of muscle moment arms estimated from MRI-based musculoskeletal models of the lower extremity. Comput Aided Surg 2000; 5: 108–119.
- 40 Besier TF, Gold GE, Beaupre GS, Delp SL. A modeling framework to estimate patellofemoral joint cartilage stress in vivo. Med Sci Sports Exerc 2005; 37: 1924–1930.
- 41 Chao EY. Graphic-based musculoskeletal model for biomechanical analyses and animation. Med Eng Phys 2003; 25: 201–212.
- 42 Penrose JM, Holt GM, Beaugonin M, Hose DR. Development of an accurate three-dimensional finite element knee model. Comput Methods Biomech Biomed Engin 2002; 5: 291–300.
- 43 Pappas GP, Blemker SS, Beaulieu CF, McAdams TR, Whalen ST, Gold GE. In vivo anatomy of the Neer and Hawkins sign positions for shoulder impingement. J Shoulder Elbow Surg 2006; 15: 40–49.
- 44 Tate CM, Williams GN, Barrance PJ, Buchanan TS. Lower extremity muscle morphology in young athletes: an MRI-based analysis. Med Sci Sports Exerc 2006; 38: 122–128.
- 45 Murray WM, Arnold AS, Salinas S, Durbhakula M, Buchanan TS, Delp SL. Building biomechanical models based on medical image data: an assessment of model accuracy. Medical Image Computing and Computer-Assisted Intervention (MICCAI '98) Lecture Notes in Computer Science. New York: Springer–Verlag; 1998; 1496: 539–549.
- 46 Blemker SS, Delp SL. Rectus femoris and vastus intermedius fiber excursions predicted by three-dimensional muscle models. J Biomech 2006; 39: 1383–1391.
- 47 Hoad CL, Martel AL. Segmentation of MR images for computer-assisted surgery of the lumbar spine. Phys Med Biol 2002; 47: 3503–3517.
- 48 Zoroofi RA, Sato Y, Nishii T, Sugano N, Yoshikawa H, Tamura S. Automated segmentation of necrotic femoral head from 3D MR data. Comput Med Imaging Graph 2004; 28: 267–278.
- 49 Fernandez JW, Mithraratne P, Thrupp SF, Tawhai MH, Hunter PJ. Anatomically based geometric modelling of the musculo-skeletal system and other organs. Biomech Model Mechanobiol 2004; 2: 139–155.
- 50 Alexander RM, Ker RF. The Architecture of Leg Muscles. In: JM Winters, SL Woo, editors. Multiple muscle systems. New York: Springer-Verlag; 1990. p 568–577.
- 51 Lieber RL, Friden J. Clinical significance of skeletal muscle architecture. Clin Orthop Relat Res 2001; 383: 140–151.
- 52 Lieber RL, Yeh Y, Baskin RJ. Sarcomere length determination using laser diffraction. Effect of beam and fiber diameter. Biophys J 1984; 45: 1007–1016.
- 53 Murray WM, Buchanan TS, Delp SL. The isometric functional capacity of muscles that cross the elbow. J Biomech 2000; 33: 943–952.
- 54 Fukunaga T, Ichinose Y, Ito M, Kawakami Y, Fukahiro S. Determination of fascicle length and pennation in contracting human muscle in vivo. J Appl Physiol 1997; 82: 354–358.
- 55 Martin DC, Medri MK, Chow RS, et al. Comparing human skeletal muscle architectural parameters of cadavers with in vivo ultrasonographic measurements. J Anat 2001; 199: 429–434.
- 56 Sinha U, Yao L. In vivo diffusion tensor imaging of human calf muscle. J Magn Reson Imaging 2002; 15: 87–95.
- 57 Heemskerk AM, Strijkers GJ, Vilanova A, Drost MR, Nicolay K. Determination of mouse skeletal muscle architecture using three-dimensional diffusion tensor imaging. Magn Reson Med 2005; 53: 1333–1340.
- 58 Blemker SS, Sherbondy AJ, Akers DL, Bammer R, Delp SL, Gold GE. Characterization of skeletal muscle fascicle arrangements using diffusion tensor tractography. In: Proceedings of the 13th Annual Meeting of ISMRM, Miami Beach, FL, USA, 2005 (Abstract 1539).
- 59 Walker PS, Rovick JS, Robertson DD. The effects of knee brace hinge design and placement on joint mechanics. J Biomech 1998; 21: 965–974.
- 60 Andriacchi TP, Alexander EJ, Toney MK, Dyrby C, Sum J. A point cluster method for in vivo motion analysis: applied to a study of knee kinematics. J Biomech Eng 1998; 120: 743–749.
- 61 Shellock FG. Functional assessment of the joints using kinematic magnetic resonance imaging. Semin Musculoskelet Radiol 2003; 7: 249–276.
- 62 Goto A, Moritomo H, Murase T, et al. In vivo three-dimensional wrist motion analysis using magnetic resonance imaging and volume-based registration. J Orthop Res 2005; 23: 750–756.
- 63 Besl PJ, McKay ND. A method for registration of 3-D shapes. IEEE Trans Pattern Anal Mach Intell 1992; 14: 239–256.
- 64 Sheehan FT, Zajac FE, Drace JE. Using cine phase contrast magnetic resonance imaging to non-invasively study in vivo knee dynamics. J Biomech 1998; 31: 21–26.
- 65 Gold GE, Besier TF, Draper CE, Asakawa DS, Delp SL, Beaupre GS. Weight-bearing MRI of patellofemoral joint cartilage contact area. J Magn Reson Imaging 2004; 20: 526–530.
- 66
Nayak KS,
Pauly JM,
Kerr AB,
Hu BS,
Nishimura DG.
Real-time color flow MRI.
Magn Reson Med
2000;
43:
251–258.
10.1002/(SICI)1522-2594(200002)43:2<251::AID-MRM12>3.0.CO;2-# CAS PubMed Web of Science® Google Scholar
- 67 Gilles B, Perrin R, Magnenat-Thalmann N, Vallee JP. Bone motion analysis from dynamic MRI: acquisition and tracking. Acad Radiol 2005; 12: 1285–1292.
- 68 Barrance PJ, Williams GN, Novotny JE, Buchanan TS. A method for measurement of joint kinematics in vivo by registration of 3-D geometric models with cine phase contrast magnetic resonance imaging data. J Biomech Eng 2005; 127: 829–837.
- 69 Pandy MG. Moment arm of a muscle force. Exerc Sport Sci Rev 1999; 27: 79–118.
- 70 An KN, Takahashi K, Harrigan TP, Chao EY. Determination of muscle orientations and moment arms. J Biomech Eng 1984; 106: 280–282.
- 71 Maganaris CN. Imaging-based estimates of moment arm length in intact human muscle-tendons. Eur J Appl Physiol 2004; 91: 130–139.
- 72 Rugg SG, Gregor RJ, Mandelbaum BR, Chiu L. In vivo moment arm calculations at the ankle using magnetic resonance imaging (MRI). J Biomech 1990; 23: 495–501.
- 73 Jorgensen MJ, Marras WS, Granata KP, Wiand JW. MRI-derived moment-arms of the female and male spine loading muscles. Clin Biomech (Bristol, Avon) 2001; 16: 182–193.
- 74 Wilson DL, Zhu Q, Duerk JL, Mansour JM, Kilgore K, Crago PE. Estimation of tendon moment arms from three-dimensional magnetic resonance images. Ann Biomed Eng 1999; 27: 247–256.
- 75 Nemeth G, Ohlsen H. Moment arm lengths of trunk muscles to the lumbosacral joint obtained in vivo with computed tomography. Spine 1986; 11: 158–160.
- 76 Ito M, Akima H, Fukunaga T. In vivo moment arm determination using B-mode ultrasonography. J Biomech 2000; 33: 215–218.
- 77 Graichen H, Englmeier KH, Reiser M, Eckstein F. An in vivo technique for determining 3D muscular moment arms in different joint positions and during muscular activation—application to the supraspinatus. Clin Biomech (Bristol, Avon) 2001; 16: 389–394.
- 78 Ward SR, Terk MR, Powers CM. Influence of patella alta on knee extensor mechanics. J Biomech 2005; 38: 2415–2422.
- 79 Blemker SS, McVeigh ER. Real-time measurements of knee muscle moment arms during dynamic knee flexion-extension motion. In: Proceedings of the 14th Annual Meeting of ISMRM, Seattle, WA, USA, 2006 (Abstract 3619).
- 80 Finni T, Hodgson JA, Lai AM, Edgerton VR, Sinha S. Mapping of movement in the isometrically contracting human soleus muscle reveals details of its structural and functional complexity. J Appl Physiol 2003; 95: 2128–2133.
- 81 Asakawa DS, Blemker SS, Gold GE, Delp SL. In vivo motion of the rectus femoris muscle after tendon transfer surgery. J Biomech 2002; 35: 1029–1037.
- 82 Tardieu C, Huet de la Tour E, Bret MD, Tardieu G. Muscle hypoextensibility in children with cerebral palsy: I. Clinical and experimental observations. Arch Phys Med Rehabil 1982; 63: 97–102.
- 83 Lieber RL, Runesson E, Einarsson F, Friden J. Inferior mechanical properties of spastic muscle bundles due to hypertrophic but compromised extracellular matrix material. Muscle Nerve 2003; 28: 464–471.
- 84 Shortland AP, Harris CA, Gough M, Robinson RO. Architecture of the medial gastrocnemius in children with spastic diplegia. Dev Med Child Neurol 2002; 44: 158–163.
- 85 Asakawa DS, Nayak KS, Blemker SS, et al. Real-time imaging of skeletal muscle velocity. J Magn Reson Imaging 2003; 18: 734–739.
- 86 Declerck J, Denney TS, Ozturk C, O'Dell W, McVeigh ER. Left ventricular motion reconstruction from planar tagged MR images: a comparison. Phys Med Biol 2000; 45: 1611–1632.
- 87 Kim D, Gilson WD, Kramer CM, Epstein FH. Myocardial tissue tracking with two-dimensional cine displacement-encoded MR imaging: development and initial evaluation. Radiology 2004; 230: 862–871.
- 88 Robson MD, Benjamin M, Gishen P, Bydder GM. Magnetic resonance imaging of the Achilles tendon using ultrashort TE (UTE) pulse sequences. Clin Radiol 2004; 59: 727–735.
- 89 Morse CI, Thom JM, Reeves ND, Birch KM, Narici MV. In vivo physiological cross-sectional area and specific force are reduced in the gastrocnemius of elderly men. J Appl Physiol 2005; 99: 1050–1055.
- 90 Asakawa DS, Blemker SS, Rab GT, Bagley A, Delp SL. Three-dimensional muscle-tendon geometry after rectus femoris tendon transfer. J Bone Joint Surg Am 2004; 86-A: 348–354.
- 91 Gold GE, Asakawa DS, Blemker SS, Delp SL. Magnetic resonance imaging findings after rectus femoris transfer surgery. Skeletal Radiol 2004; 33: 34–40.
- 92 Bensamoun SF, Ringleb SI, Littrell L, et al. Determination of thigh muscle stiffness using magnetic resonance elastography. J Magn Reson Imaging 2006; 23: 242–247.
- 93
Dresner MA,
Rose GH,
Rossman PJ,
Muthupillai R,
Manduca A,
Ehman RL.
Magnetic resonance elastography of skeletal muscle.
J Magn Reson Imaging
2001;
13:
269–276.
10.1002/1522-2586(200102)13:2<269::AID-JMRI1039>3.0.CO;2-1 CAS PubMed Web of Science® Google Scholar
- 94 Jenkyn TR, Ehman RL, An KN. Noninvasive muscle tension measurement using the novel technique of magnetic resonance elastography (MRE). J Biomech 2003; 36: 1917–1921.