Monitoring and visualization techniques for MR-guided laser ablations in an open MR system
Corresponding Author
Joachim Kettenbach MD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115Search for more papers by this authorStuart G. Silverman MD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorNobuhiko Hata PhD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorKagayaki Kuroda PhD
Department of Electrical Engineering, Faculty of Engineering, Osaka City University, Japan
Search for more papers by this authorPairash Saiviroonporn PhD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorGary P. Zientara PhD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorPaul R. Morrison MS
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorStephen G. Hushek PhD
General Electric, Medical Systems, Milwaukee, WI
Search for more papers by this authorPeter McL. Black MD, PhD
Division of Neurosurgery, Department of Surgery, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorRon Kikinis MD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorFerenc A. Jolesz MD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorCorresponding Author
Joachim Kettenbach MD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115Search for more papers by this authorStuart G. Silverman MD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorNobuhiko Hata PhD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorKagayaki Kuroda PhD
Department of Electrical Engineering, Faculty of Engineering, Osaka City University, Japan
Search for more papers by this authorPairash Saiviroonporn PhD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorGary P. Zientara PhD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorPaul R. Morrison MS
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorStephen G. Hushek PhD
General Electric, Medical Systems, Milwaukee, WI
Search for more papers by this authorPeter McL. Black MD, PhD
Division of Neurosurgery, Department of Surgery, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorRon Kikinis MD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorFerenc A. Jolesz MD
Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Search for more papers by this authorAbstract
Our purpose was to develop temperature-sensitive MR sequences and image-processing techniques to assess their potential of monitoring interstitial laser therapy (ILT) in brain tumors (n = 3) and liver tumors (n = 7). ILT lasted 2 to 26 minutes, whereas images from T1-weighted fast-spin-echo (FSE) or spoiled gradient-recalled (SPGR) sequences were acquired within 5 to 13 seconds. Pixel subtraction and visualization of T1-weighted images or optical flow computation was done within less than 110 msec. Alternating phase-mapping of real and imaginary components of SPGR sequences was performed within 220 msec. Pixel subtraction of T1-weighted images identified thermal changes in liver and brain tumors but could not evaluate the temperature values as chemical shift-based imaging, which was, however, more affected by susceptibility effects and motion. Optical flow computation displayed the predicted course of thermal changes and revealed that the rate of heat deposition can be anisotropic, which may be related to heterogeneous tumor structure and/or vascularization.
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