Synthesis and Antimicrobial Activity of N-[(2Z)-3-(4,6-Substitutedpyrimidin-2-yl)-4-phenyl-1,3-thiazol-2(3H)-ylidene]-3, 5-dinitrobenzamide Analogues
Corresponding Author
Sohail Saeed
Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad 44000, Pakistan
National Engineering and Scientific Commission, P.O. Box 2801, Islamabad, Pakistan
E-mail: [email protected]Search for more papers by this authorRizwan Hussain
National Engineering and Scientific Commission, P.O. Box 2801, Islamabad, Pakistan
Search for more papers by this authorMuhammad Ali
Department of Pharmacy, University of the Punjab, Lahore-54590, Pakistan
Search for more papers by this authorCorresponding Author
Sohail Saeed
Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad 44000, Pakistan
National Engineering and Scientific Commission, P.O. Box 2801, Islamabad, Pakistan
E-mail: [email protected]Search for more papers by this authorRizwan Hussain
National Engineering and Scientific Commission, P.O. Box 2801, Islamabad, Pakistan
Search for more papers by this authorMuhammad Ali
Department of Pharmacy, University of the Punjab, Lahore-54590, Pakistan
Search for more papers by this authorAbstract
In this study, we have synthesized 1-(4,6-disubstitutedpyrimidin-2-yl)-3-(3,5-dinitrobenzoyl)-thiourea derivatives (1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h) and N-[(2Z)-3-(4,6-disubstitutedpyrimidin-2-yl)-4-phenyl-1,3-thiazol-2(3H)-ylidene]-3, 5-dinitrobenzamide (2a-2h) analogues and characterized by IR spectroscopy, NMR spectroscopy, elemental analysis, and single crystal X-ray diffraction data. The compounds (2a-2h) were screened for antimicrobial activity against Gram positive, Gram negative, and fungal species. The results of antimicrobial study indicated that compounds showed most potential and appreciable antibacterial and antifungal activities.
Supporting Information
Additional Supporting Information may be found in the online version of this article.
| Filename | Description |
|---|---|
| jhet964-sup-0001-SupportingInfo.docPDF document, 372 KB | Supporting Information: 1H-NMR of compounds 2, 4–9 and L1–L3. UV spectra of L1–L3. |
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