Volume 24, Issue 4 pp. 949-953

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Polycyclic N-hetero compounds. XXII^† Reaction of pyridine N-oxides and Pyrazine di-N-oxides with formamide

Takashi Hirota,

Takashi Hirota

Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700, Japan

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Tetsuto Namba,

Tetsuto Namba

Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700, Japan

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Kenji Sasaki,

Kenji Sasaki

Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700, Japan

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Takashi Hirota,

Takashi Hirota

Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700, Japan

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Tetsuto Namba,

Tetsuto Namba

Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700, Japan

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Kenji Sasaki,

Kenji Sasaki

Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700, Japan

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First published: July/August 1987

https://doi.org/10.1002/jhet.5570240412

Citations: 6

^†

Part XXI: T. Hirota, M. Fukumoto, K. Sasaki, T. Namba, and S. Hayakawa, Heterocycles, 24, 143 (1986).

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Abstract

Reactions of pyridine N-oxides, pyrazine di-N-oxides, and their benzologues with formamide are described. Carbamoylation mainly occurred at aromatic ring with loss of the N-oxide oxygen atom, however, 2,4,6-trimethylpyridine 1-oxide gave 2- and 4-pyrimidinyl derivatives.

References and Notes

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Volume24, Issue4

July/August 1987

Pages 949-953

Polycyclic N-hetero compounds. XXII^† Reaction of pyridine N-oxides and Pyrazine di-N-oxides with formamide

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Polycyclic N-hetero compounds. XXII† Reaction of pyridine N-oxides and Pyrazine di-N-oxides with formamide

Abstract

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Polycyclic N-hetero compounds. XXII^† Reaction of pyridine N-oxides and Pyrazine di-N-oxides with formamide