7,8-Dihydroxychlorpromazine and 2-chloro-7,8-dihydroxyphenothiazine were converted to the corresponding 7,8-dioxo compounds by oxidation with tetrachloro-o-quinone. Spectral properties indicate that the 7,8-dioxo compounds exist in zwitterionic forms reminiscent of aminochromes. The 7,8-dioxochlorpromazine is proposed as a possible metabolite of chlorpromazine.

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Volume12, Issue2

April 1975

Pages 239-242

7,8-Dioxochlorpromazine, synthesis and properties

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7,8-Dioxochlorpromazine, synthesis and properties

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