Synthesis of Some New Azoloazines with Potent Anti-inflammatory and Analgesic Activity
Dina H. Dawood
Department of Chemistry of Natural and Microbial Products, National Research Centre, Dokki, 12622 Giza, Egypt
Search for more papers by this authorRabab S. Jasass
Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah, 21955 Saudi Arabia
Search for more papers by this authorMohamed M. Amin
Department of Pharmacology, Medical Division, National Research Centre, 33 EL Bohouthst (former EL Tahrirst), Dokki, 12622 Giza, Egypt
Search for more papers by this authorThoraya A. Farghaly
Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah, 21955 Saudi Arabia
Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613 Egypt
Search for more papers by this authorCorresponding Author
Eman M. H. Abbas
Department of Chemistry of Natural and Microbial Products, National Research Centre, Dokki, 12622 Giza, Egypt
E-mail: [email protected]Search for more papers by this authorDina H. Dawood
Department of Chemistry of Natural and Microbial Products, National Research Centre, Dokki, 12622 Giza, Egypt
Search for more papers by this authorRabab S. Jasass
Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah, 21955 Saudi Arabia
Search for more papers by this authorMohamed M. Amin
Department of Pharmacology, Medical Division, National Research Centre, 33 EL Bohouthst (former EL Tahrirst), Dokki, 12622 Giza, Egypt
Search for more papers by this authorThoraya A. Farghaly
Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah, 21955 Saudi Arabia
Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613 Egypt
Search for more papers by this authorCorresponding Author
Eman M. H. Abbas
Department of Chemistry of Natural and Microbial Products, National Research Centre, Dokki, 12622 Giza, Egypt
E-mail: [email protected]Search for more papers by this authorAbstract
Starting from pyrimidine-2-thiones, a set of new fused triazoles, thiazoles, and thiazines has been obtained. The mechanistic pathway and structures of all the novel products were ascertained on the foundation of spectral information and elemental analyses. The analgesic and anti-inflammatory activities of all the prepared compounds were predestined. The outcomes disclosed that all of the examined samples revealed potent activity. Moreover, the relation between the structure and the activity has been researched.
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