Volume 54, Issue 2 pp. 850-858

Article

Synthesis and Antimicrobial Activity of Some Novel Quinoline, Chromene, Pyrazole Derivatives Bearing Triazolopyrimidine Moiety

A. A. Abu-Hashem,

A. A. Abu-Hashem

Department of Photochemistry (Heterocyclic Unit), National Research Center, Dokki, Giza, 12622 Egypt

Department of Chemistry, Faculty of Science, Jazan University, 2097 Jezan, Saudi Arabia

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M. A. Gouda,

Corresponding Author

M. A. Gouda

[email protected]

Department of Chemistry, Faculty of Science and Arts, Ulla, Taibah University, KSA

Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, 35516 Mansoura, Egypt

E-mail: [email protected]Search for more papers by this author

A. A. Abu-Hashem,

A. A. Abu-Hashem

Department of Photochemistry (Heterocyclic Unit), National Research Center, Dokki, Giza, 12622 Egypt

Department of Chemistry, Faculty of Science, Jazan University, 2097 Jezan, Saudi Arabia

Search for more papers by this author

M. A. Gouda,

Corresponding Author

M. A. Gouda

[email protected]

Department of Chemistry, Faculty of Science and Arts, Ulla, Taibah University, KSA

Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, 35516 Mansoura, Egypt

E-mail: [email protected]Search for more papers by this author

First published: 22 April 2016

https://doi.org/10.1002/jhet.2645

Citations: 25

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Abstract

7-Amino-3-phenyl-[1,2,4]triazolo [4,3-a] pyrimidin-5(1H)-one (5) was utilized as key intermediate for the synthesis of some new, quinolines 9, 10, 11, 12, 13, 14 and 18, 19, 20, acrylonitrile 25 and 28, coumarin 26, and pyrazoles 31, 32, 33, 34 incorporating triazolopyrimidines. The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, ¹H NMR, and mass spectral data. Representative compounds of the synthesized products were tested and evaluated as antimicrobial. Compounds 25, 28, 31, 32, 33, and 34 are the most promising.

References and Notes

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Volume54, Issue2

March 2017

Pages 850-858

Synthesis and Antimicrobial Activity of Some Novel Quinoline, Chromene, Pyrazole Derivatives Bearing Triazolopyrimidine Moiety

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Synthesis and Antimicrobial Activity of Some Novel Quinoline, Chromene, Pyrazole Derivatives Bearing Triazolopyrimidine Moiety

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