Original Article

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Prevalence of autoantibodies in patients of psoriasis

Sangeeta Singh

Division of Immunopathology, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

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Usha Singh,

Corresponding Author

Usha Singh

[email protected]

UGC Advanced Immunodiagnostic, Training & Research Centre, Division of Immunopathology, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Division of Immunopathology, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, IndiaSearch for more papers by this author

Sanjay Singh,

Sanjay Singh

Department of Dermatology & Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

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Sangeeta Singh,

Sangeeta Singh

Division of Immunopathology, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

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Usha Singh,

Corresponding Author

Usha Singh

[email protected]

UGC Advanced Immunodiagnostic, Training & Research Centre, Division of Immunopathology, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Division of Immunopathology, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, IndiaSearch for more papers by this author

Sanjay Singh,

Sanjay Singh

Department of Dermatology & Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

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First published: 19 January 2010

https://doi.org/10.1002/jcla.20365

Citations: 18

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Abstract

Psoriasis is a common chronic inflammatory disease of the skin and joints. Autoantibodies have been reported in psoriasis patients. Objective of the study was to see the prevalence of various autoantibodies in patients of psoriasis and its correlation with gender, age, and type. Anti-nuclear antibody and antibody to double-stranded deoxyribonucleic acid were studied by indirect enzyme linked immunosorbent assay, rheumatoid factor was done by latex agglutination, whereas anti-thyroid microsomal antibody (anti-TMA) was by gelatin agglutination method. About 28.8% of psoriasis cases were positive for atleast one autoantibody. Age of onset (P=0.033) and types of psoriasis (P=0.037) had significant association with gender. Anti-double-stranded deoxyribonucleic acid (P=0.029) and anti-thyroid microsomal antibody (P=0.002) had significant association with types of psoriasis. Gender wise distribution of psoriasis in age group had significant (P=0.03) association with anti-TMA. This study concludes that the autoantibodies are found to be present in psoriasis patients or latent autoimmune diseases develop in psoriasis patients without any clinical symptoms. J. Clin. Lab. Anal. 24:44–48, 2010. © 2010 Wiley-Liss, Inc.

REFERENCES

1Raychaudhuri SP, Faber EM. The prevalence of psoriasis in the world. J European Acad Dermatol Venereol 2007; 15: 16–17.
10.1046/j.1468-3083.2001.00192.x
Web of Science® Google Scholar
2Michelle AL, Anne MB, James GK. Review article pathogenesis and therapy of psoriasis. Nature 2007; 445: 866–873.
10.1038/nature05663
PubMed Web of Science® Google Scholar
3Kabadi UM. Onset of type I diabetes mellitus, hypothyroidism and hypogonadism on withdrawal of glucocorticoid therapy and remission on its resumption in a patient with rheumatoid arthritis. Am J Med 1986; 80: 139–142.
10.1016/0002-9343(86)90065-3
PubMed Web of Science® Google Scholar
4Guerin V, Bene MC, Barbe F, Amiel C, Faure C. Stigmates autoimmunitaires thyrodiens au cours de la polyarthritic reumatoide. Rev Rhum 1987; 54: 438.
PubMed Web of Science® Google Scholar
5Leitch DN, Haslock DI. Psoriatic arthritis arthritis and minocycline induced autoantibodies. Clinical Rheumatol 1997; 16: 317–318.
10.1007/BF02238971
CAS PubMed Web of Science® Google Scholar
6Janjumratsang P, Phainupong D, Chanjanakijskul S, Roongphibulsopit P. Positive direct immunofluorescence and autoantibody profiles in psoriasis patients. J Dermatol 2008; 35: 508–513.
10.1111/j.1346-8138.2008.00512.x
CAS PubMed Web of Science® Google Scholar
7Lorber M, Gershwin ME, Shoenfeld Y. The coexistence of systemic lupus erythematosus with other autoimmune diseases: The kaleidoscope of autoimmunity. Semin Arthritis Rheum 1994; 24: 105–113.
10.1016/S0049-0172(05)80004-6
CAS PubMed Web of Science® Google Scholar
8Zalla MJ, Muller SA. The coexistence of psoriasis with lupus erythematosus and other photosensitive disorders. Acta Derm Verereol 1996; 195: 1–15.
CAS PubMed Google Scholar
9Sticherling M. Mechanism of psoriasis. Drug Discov Today Dis Mech 2005; 2: 275–281.
10.1016/j.ddmec.2005.05.019
CAS Google Scholar
10Tagami H, Iwatsuki K, Yamada M. Profile of anti-stratum corneum autoantibodies in psoriatic patients. Arch Dermatol Res 1983; 275: 71–75.
10.1007/BF00412877
CAS PubMed Web of Science® Google Scholar
11Aoki S, Yaotia H, Kitajima Y. An elevated level of autoantibodies against 48- to 50-kd keratins in the serum of patients with psoriasis. J Invest Dermatol 1989; 92: 179–183.
10.1111/1523-1747.ep12276700
CAS PubMed Web of Science® Google Scholar
12Pérez-Lorenzo R, Zambrano-Zaragoza JF, Saul A, Jiménez-Zamudio L, Reyes-Maldonado E, García-Latorre E. Autoantibodies to autologous skin in guttate and plaque forms of psoriasis and cross-reaction of skin antigens with streptococcal antigens. Int J Dermatol 1998; 37: 524–531.
10.1046/j.1365-4362.1998.00512.x
CAS PubMed Web of Science® Google Scholar
13Matsushita Y, Shimada Y, Kawara S, Takehara K, Sato S. Autoantibodies directed against the protease inhibitor calpastatin in psoriasis. Clin Exp Immunol 2005; 139: 355–362.
10.1111/j.1365-2249.2005.02701.x
CAS PubMed Web of Science® Google Scholar
14Astudillo L, Sailler L, Carreiro M, Dahan S, Ollier S, Arlet P. Psoriasis and systemic lupus erythematosus: A rare association with specific therapeutic problem. Ann Med Interne 2003; 154: 3–6.
PubMed Web of Science® Google Scholar
15Kutukculer N, Yuksel SE, Aksu G, Alper S. Autoantibodies other than antineutrophil cytoplasmic antibodies are not positive in patients with psoriasis vulgaris. J Dermatol 1995; 32: 179–185.
10.1111/j.1346-8138.2005.tb00741.x
Google Scholar
16Feletar M, Brockbank JE, Schentag CT, Lapp V, Gladman DD. Treatment of refractory psoriatic arthritis with infliximab: A 12-month observational study of 16 patients. Ann Rheum Dis 2004; 63: 156–161.
10.1136/ard.2003.006775
CAS PubMed Web of Science® Google Scholar
17Lorber M, Gershwin ME, Shoenfeld Y. The coexistence of systemic lupus erythematosus with other autoimmune diseases: The kaleidoscope of autoimmunity. Semin Arthritis Rheum 1994; 24: 105–113.
10.1016/S0049-0172(05)80004-6
CAS PubMed Web of Science® Google Scholar
18Bianchi G, Marchesini G, Zoli M, et al. Thyroid involvement in chronic inflammatory rheumatological disorders. Clinical Rheumatol 1994; 13: 479–484.
Google Scholar
19Antonelli A, Delle Sedie A, Fallahi P, et al. High prevalence of thyroid autoimmunity and hypothyroidism in patients with psoriatic arthritis. J Rheumatol 2006; 33: 2026–2028.
PubMed Web of Science® Google Scholar
20Bowcock AM. Understanding the pathogenesis of psoriasis, psoriatic arthritis and autoimmunity via a fusion of molecular genetics and immunology. Immunol Res 2005; 32: 45–56.
10.1385/IR:32:1-3:045
CAS PubMed Web of Science® Google Scholar
21Atassi MZ, Casali P. Molecular mechanisms of autoimmunity. Autoimmunity 2008; 41: 123–132.
10.1080/08916930801929021
CAS PubMed Web of Science® Google Scholar
22Valdimarsson H, Thorleifsdottir RH, Sigurdardottir SL, Gudjonsson JE, Johnston A. Psoriasis—as an autoimmune disease caused by molecular mimicry. Trends Immunol 2009; 30: 494–501.
10.1016/j.it.2009.07.008
CAS PubMed Web of Science® Google Scholar

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2010

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Prevalence of autoantibodies in patients of psoriasis

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Prevalence of autoantibodies in patients of psoriasis

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