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Mechanical stress and osteogenesis in vitro
Elisabeth H. Burger,
Jenneke Klein-Nulend,
J. Paul Veldhuijzen,
Corresponding Author
Elisabeth H. Burger
Department of Oral Cell Biology, Academic Center of Dentistry (ACTA), Vrije Universiteit, Amsterdam, The Netherlands
Department of Oral Cell Biology ACTA-VU Van der Boechorststraat 7 NL 1081 BT Amsterdam, The NetherlandsSearch for more papers by this authorJenneke Klein-Nulend
Department of Oral Cell Biology, Academic Center of Dentistry (ACTA), Vrije Universiteit, Amsterdam, The Netherlands
Search for more papers by this authorJ. Paul Veldhuijzen
Department of Oral Cell Biology, Academic Center of Dentistry (ACTA), Vrije Universiteit, Amsterdam, The Netherlands
Search for more papers by this authorElisabeth H. Burger,
Jenneke Klein-Nulend,
J. Paul Veldhuijzen,
Corresponding Author
Elisabeth H. Burger
Department of Oral Cell Biology, Academic Center of Dentistry (ACTA), Vrije Universiteit, Amsterdam, The Netherlands
Department of Oral Cell Biology ACTA-VU Van der Boechorststraat 7 NL 1081 BT Amsterdam, The NetherlandsSearch for more papers by this authorJenneke Klein-Nulend
Department of Oral Cell Biology, Academic Center of Dentistry (ACTA), Vrije Universiteit, Amsterdam, The Netherlands
Search for more papers by this authorJ. Paul Veldhuijzen
Department of Oral Cell Biology, Academic Center of Dentistry (ACTA), Vrije Universiteit, Amsterdam, The Netherlands
Search for more papers by this authorAbstract
The use of hydrostatic pressure to apply mechanical stress to bone organ cultures is reviewed. Ossifying long bones and calvarial rudiments are sensitive to this type of stress. Intermittent hydrostatic compression of near physiologic magnitude (ICF) has anabolic effects on mineral metabolism in such rudiments, and continuous hydrostatic stress of high magnitude (CCP) has catabolic effects. The effects of ICF may be ascribed to shear stress generated at tissue interphases of different chemical and mechanical properties. Local factors, such as prostaglandins and growth factors, seem to be involved in the tissue response to mechanical stress.
References
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