Structural optimization and finite element analysis of poly-l-lactide acid coronary stent with improved radial strength and acute recoil rate
Kai Song
Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan, China
Search for more papers by this authorYuying Bi
Dongguan TT Medical Inc., Guangdong, China
Biomedical Engineering and Biotechnology, University of Massachusetts, Lowell, Massachusetts
Search for more papers by this authorCorresponding Author
Haibin Zhao
Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan, China
Shenzhen Research Institute of Shandong University, Shenzhen, Guangdong, China
Correspondence
Haibin Zhao, Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan, Shandong, China 250061.
Email: [email protected]
Search for more papers by this authorTim Wu
Dongguan TT Medical Inc., Guangdong, China
Biomedical Engineering and Biotechnology, University of Massachusetts, Lowell, Massachusetts
Search for more papers by this authorFeng Xu
Department of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China
Search for more papers by this authorGuoqun Zhao
Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan, China
Search for more papers by this authorKai Song
Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan, China
Search for more papers by this authorYuying Bi
Dongguan TT Medical Inc., Guangdong, China
Biomedical Engineering and Biotechnology, University of Massachusetts, Lowell, Massachusetts
Search for more papers by this authorCorresponding Author
Haibin Zhao
Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan, China
Shenzhen Research Institute of Shandong University, Shenzhen, Guangdong, China
Correspondence
Haibin Zhao, Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan, Shandong, China 250061.
Email: [email protected]
Search for more papers by this authorTim Wu
Dongguan TT Medical Inc., Guangdong, China
Biomedical Engineering and Biotechnology, University of Massachusetts, Lowell, Massachusetts
Search for more papers by this authorFeng Xu
Department of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China
Search for more papers by this authorGuoqun Zhao
Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan, China
Search for more papers by this authorFunding information: National Natural Science Foundation of China, Grant/Award Number: 51873099; Natural Science Foundation of Shandong Province, Grant/Award Number: ZR2019QEE011; Natural Science Foundation of Guangdong Province, Funding Number 2020A1515011395; Fundamental Research Funds of Shandong University, Grant/Award Number: 2018JC057; Innovative and Entrepreneurial Research Team Program of Guangdong, Grant/Award Number: 2014ZT05S008
Abstract
Current poly-l-lactide acid (PLLA) scaffolds have issues of inadequate mechanical strength leading to thrombosis formation. Designing a novel bioabsorbable PLLA stent with a novel structure and improved mechanical property is urgently needed. In this study, stent structure modification and optimization based on bioresorbable vascular scaffold Version 1.1 (BVS 1.1, Abbott Laboratories) were conducted. The mechanical property of the redesigned stent was studied using both computerized finite element analysis and experimental mechanical deformation testing, including radial strength (RS), acute recoil (AR), foreshortening (FS), and bending stiffness (BS). The simulated and experimental results showed that the mechanical properties of the modified structure were significantly improved (modified stent vs. BVS 1.1: RS: 2.25 vs. 1.29 N/mm; AR: 3.03 vs. 4.41%; FS: 1.13 vs. 6.89%; BS: 1.49 vs. 0.72 N mm2).
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