Prophylactic onlay reinforcement with absorbable mesh (polyglactin) is associated with less early wound complications after kidney transplantation: A preliminary study
Christoph W. Michalski
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorSara Mohammadi
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorElias Khajeh
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorOmid Ghamarnejad
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorMohammadsadegh Sabagh
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorFrank Pianka
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorMohammad Golriz
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorYakup Kulu
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorFriedrich Kallinowski
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Hernia Center, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorMartin Zeier
Division of Nephrology, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorChristian Morath
Division of Nephrology, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorMarkus K. Diener
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorMarkus W. Büchler
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorCorresponding Author
Arianeb Mehrabi
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Correspondence to: A. Mehrabi; e-mail: [email protected]Search for more papers by this authorChristoph W. Michalski
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorSara Mohammadi
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorElias Khajeh
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorOmid Ghamarnejad
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorMohammadsadegh Sabagh
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorFrank Pianka
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorMohammad Golriz
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorYakup Kulu
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorFriedrich Kallinowski
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Hernia Center, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorMartin Zeier
Division of Nephrology, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorChristian Morath
Division of Nephrology, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorMarkus K. Diener
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorMarkus W. Büchler
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Search for more papers by this authorCorresponding Author
Arianeb Mehrabi
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Correspondence to: A. Mehrabi; e-mail: [email protected]Search for more papers by this authorAbstract
Incidence of wound complications after kidney transplantation (KTx) is still considerable. Here, we report the impact of prophylactic absorbable polyglactin (Vicryl®) mesh reinforcement on the incidence of short-term post-KTx wound complications. Sixty-nine patients were analyzed; 23 with and 46 without preventive onlay mesh reinforcement. Surgical site infections (SSI) were seen in six (26%) patients in the mesh group and in 17 (37%) patients in no-mesh group. A lower, but not statistically significant, rate of early postoperative wound complications occurred in the mesh group. Wound complications were observed in seven (30%) patients in the mesh group and in 23 (50%) patients in the no-mesh group. There was no association between mesh placement and SSI incidence (odds ratios [OR] 0.60, 95% confidence interval [CI] 0.20–1.82, p = 0.369) and wound complications (OR 0.44, 95% CI 0.15–1.26, p = 0.126). Therefore, we conclude that mesh reinforcement does not increase the risk of SSI and overall wound complications. Long-term outcomes have to be evaluated in a randomized trial setting. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:67–72, 2020.
REFERENCES
- 1Mehrabi A, Fonouni H, Wente M, Sadeghi M, Eisenbach C, Encke J, Schmied BM, Libicher M, Zeier M, Weitz J and others. Wound complications following kidney and liver transplantation. Clin Transplant 2006; 20 Suppl 17: 97–110.
- 2Roine E, Bjork IT, Oyen O. Targeting risk factors for impaired wound healing and wound complications after kidney transplantation. Transplant Proc 2010; 42(7): 2542–2546.
- 3Mehrabi A, Wiesel M, Zeier M, Kashfi A, Schemmer P, Kraus T, Buchler MW, Schmidt J. Results of renal transplantation using kidneys harvested from living donors at the University of Heidelberg. Nephrol Dial Transplant 2004; 19(Suppl 4): iv48–iv54.
- 4van Ramshorst GH, Nieuwenhuizen J, Hop WC, Arends P, Boom J, Jeekel J, Lange JF. Abdominal wound dehiscence in adults: Development and validation of a risk model. World J Surg 2010; 34(1): 20–27.
- 5Tran A, Miniard J. Preventing infections after renal transplant. Nursing 2017; 47(1): 57–60.
- 6Shrestha BM. Systematic review of the negative pressure wound therapy in kidney transplant recipients. World J Transplant 2016; 6(4): 767–773.
- 7Wood LN, Yang W, Annamalai A. Mesh hood fascial closure is a safe alternative to prevent renal allograft compartment syndrome during kidney transplantation. Transplant Proc 2015; 47(6): 1845–1849.
- 8Diener MK, Knebel P, Kieser M, Schuler P, Schiergens TS, Atanassov V, Neudecker J, Stein E, Thielemann H, Kunz R, et al. Effectiveness of triclosan-coated PDS plus versus uncoated PDS II sutures for prevention of surgical site infection after abdominal wall closure: The randomised controlled PROUD trial. Lancet 2014; 384(9938): 142–152.
- 9Mueller TC, Loos M, Haller B, Mihaljevic AL, Nitsche U, Wilhelm D, Friess H, Kleeff J, Bader FG. Intra-operative wound irrigation to reduce surgical site infections after abdominal surgery: A systematic review and meta-analysis. Langenbecks Arch Surg 2015; 400(2): 167–181.
- 10Sandy-Hodgetts K, Carville K, Leslie GD. Determining risk factors for surgical wound dehiscence: A literature review. Int Wound J 2015; 12(3): 265–275.
- 11Gowda AU, McNichols CH, Asokan I, Matthews JA, Buckingham EB, Sabino J, Maddox JS, Slezak S, Rasko Y, Singh DP. Porcine acellular dermal matrix for hernia repair in transplant patients. Ann Plast Surg 2016; 77(6): 674–677.
- 12Varga M, Matia I, Kucera M, Oliverius M, Adamec M. Polypropylene mesh repair of incisional hernia after kidney transplantation: Single-center experience and review of the literature. Ann Transplant 2011; 16(3): 121–125.
- 13Jairam AP, Timmermans L, Eker HH, Pierik R, van Klaveren D, Steyerberg EW, Timman R, van der Ham AC, Dawson I, Charbon JA, et al. Prevention of incisional hernia with prophylactic onlay and sublay mesh reinforcement versus primary suture only in midline laparotomies (PRIMA): 2-year follow-up of a multicentre, double-blind, randomised controlled trial. Lancet 2017; 390(10094): 567–576.
- 14Wang XC, Zhang D, Yang ZX, Gan JX, Yin LN. Mesh reinforcement for the prevention of incisional hernia formation: A systematic review and meta-analysis of randomized controlled trials. J Surg Res 2017; 209: 17–29.
- 15Pentlow A, Smart NJ, Richards SK, Inward CD, Morgan JD. The use of porcine dermal collagen implants in assisting abdominal wall closure of pediatric renal transplant recipients with donor size discrepancy. Pediatr Transplant 2008; 12(1): 20–23.
- 16FitzGerald JF, Kumar AS. Biologic versus synthetic mesh reinforcement: What are the pros and cons? Clin Colon Rectal Surg 2014; 27(4): 140–148.
- 17Goldfarb DA. Are wound complications after a kidney transplant more common with modern immunosuppression? J Urol 2002; 168(3): 1294.
- 18Cuomo R, Nisi G, Grimaldi L, Brandi C, Sisti A, D'Aniello C. Immunosuppression and abdominal wall defects: Use of autologous dermis. In Vivo 2015; 29(6): 753–755.
- 19Susal C, Fichtner A, Tonshoff B, Mehrabi A, Zeier M, Morath C. Clinical relevance of HLA antibodies in kidney transplantation: Recent data from the Heidelberg transplant center and the collaborative transplant study. J Immunol Res 2017; 2017: 5619402.
- 20Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care–associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008; 36(5): 309–332.
- 21Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC definitions of nosocomial surgical site infections, 1992: A modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol 1992; 13(10): 606–608.
- 22Mehrabi A, Golriz M, Maier J, Fonouni H, Garoussi C, Hafezi M, Fard N, Faridar A, Rezaei N, Wiesel M, et al. Long-term follow-up of kidney transplant recipients with polycystic kidney disease. Exp Clin Transplant 2015; 13(5): 413–420.
- 23Moris D, Davakis S, Kakavia K, Bokos J, Vernadakis S, Diles K, Sotirchos G, Barlas A, Psychogiou M, Zavos G. Incisional infections after renal transplant: Outcome data from 238 consecutive recipients. Exp Clin Transplant 2017; 15(4): 405–413.
- 24Abdelfatah MM, Rostambeigi N, Podgaetz E, Sarr MG. Long-term outcomes (>5-year follow-up) with porcine acellular dermal matrix (Permacol) in incisional hernias at risk for infection. Hernia 2015; 19(1): 135–140.
- 25Carbonell AM, Cobb WS. Safety of prosthetic mesh hernia repair in contaminated fields. Surg Clin 2013; 93(5): 1227–1239.
- 26Carbonell AM, Criss CN, Cobb WS, Novitsky YW, Rosen MJ. Outcomes of synthetic mesh in contaminated ventral hernia repairs. J Am Coll Surg 2013; 217(6): 991–998.
- 27Timmermans L, Eker HH, Steyerberg EW, Jairam A, de Jong D, Pierik EG, Lases SS, van der Ham AC, Dawson I, Charbon J, et al. Short-term results of a randomized controlled trial comparing primary suture with primary glued mesh augmentation to prevent incisional hernia. Ann Surg 2015; 261(2): 276–281.
- 28Abo-Ryia MH, El-Khadrawy OH, Abd-Allah HS. Prophylactic preperitoneal mesh placement in open bariatric surgery: A guard against incisional hernia development. Obes Surg 2013; 23(10): 1571–1574.
- 29Harris HW, Hope WH, Adrales G, Andersen DK, Deerenberg EB, Diener H, Dumanian G, East B, Fischer JP, Urena MAG, et al. Contemporary concepts in hernia prevention: Selected proceedings from the 2017 international symposium on prevention of incisional hernias. Surgery 2018; 164(2): 319–326.
- 30Richards SK, Lear PA, Huskisson L, Saleem MA, Morgan JD. Porcine dermal collagen graft in pediatric renal transplantation. Pediatr Transplant 2005; 9(5): 627–629.
- 31Grevious MA, Iqbal R, Raofi V, Beatty E, Oberholzer J, Cohen M, Abcarian H, Testa G, Benedetti E. Staged approach for abdominal wound closure following combined liver and intestinal transplantation from living donors in pediatric patients. Pediatr Transplant 2009; 13(2): 177–181.
- 32Engelsman AF, van der Mei HC, Ploeg RJ, Busscher HJ. The phenomenon of infection with abdominal wall reconstruction. Biomaterials 2007; 28(14): 2314–2327.
- 33Kaufmann R, Halm JA, Eker HH, Klitsie PJ, Nieuwenhuizen J, van Geldere D, Simons MP, van der Harst E, van't Riet M, van der Holt B, et al. Mesh versus suture repair of umbilical hernia in adults: A randomised, double-blind, controlled, multicentre trial. Lancet 2018; 391(10123): 860–869.
- 34Pans A, Elen P, Dewé W, Desaive C. Long-term results of polyglactin mesh for the prevention of incisional hernias in obese patients. World J Surg 1998; 22(5): 479–483.
- 35Muysoms FE, Detry O, Vierendeels T, Huyghe M, Miserez M, Ruppert M, Tollens T, Defraigne JO, Berrevoet F. Prevention of incisional hernias by prophylactic mesh-augmented reinforcement of midline laparotomies for abdominal aortic aneurysm treatment: A randomized controlled trial. Ann Surg 2016; 263(4): 638–645.
- 36Stremitzer S, Bachleitner-Hofmann T, Gradl B, Gruenbeck M, Bachleitner-Hofmann B, Mittlboeck M, Bergmann M. Mesh graft infection following abdominal hernia repair: Risk factor evaluation and strategies of mesh graft preservation. A retrospective analysis of 476 operations. World J Surg 2010; 34(7): 1702–1709.
- 37Taha M, Davis NF, Power R, Mohan P, Forde J, Smyth G, Little DM. Increased mid-abdominal circumference is a predictor for surgical wound complications in kidney transplant recipients: A prospective cohort study. Clin Transplant 2017; 31(5): 1–6.
- 38Webster C, Neumayer L, Smout R, Horn S, Daley J, Henderson W, Khuri S. Prognostic models of abdominal wound dehiscence after laparotomy. J Surg Res 2003; 109(2): 130–137.
- 39Hennessey DB, Burke JP, Ni-Dhonochu T, Shields C, Winter DC, Mealy K. Preoperative hypoalbuminemia is an independent risk factor for the development of surgical site infection following gastrointestinal surgery: A multi-institutional study. Ann Surg 2010; 252(2): 325–329.
- 40Valente JF, Hricik D, Weigel K, Seaman D, Knauss T, Siegel CT, Bodziak K, Schulak JA. Comparison of sirolimus vs. mycophenolate mofetil on surgical complications and wound healing in adult kidney transplantation. Am J Transplant 2003; 3(9): 1128–1134.
- 41Aksamija G, Mulabdic A, Rasic I, Aksamija L. Evaluation of risk factors of surgical wound dehiscence in adults after laparotomy. Med Arch 2016; 70(5): 369–372.
- 42Shander A, Javidroozi M, Naqvi S, Aregbeyen O, Caylan M, Demir S, Juhl A. An update on mortality and morbidity in patients with very low postoperative hemoglobin levels who decline blood transfusion (CME). Transfusion 2014; 54(10 Pt 2): 2688–2695. quiz 2687.