Osteogenic activity and antibacterial effect of porous titanium modified with metal-organic framework films
Junyu Chen
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
These authors contributed equally to this work.
Search for more papers by this authorXin Zhang
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
College of Chemistry, Sichuan University, Chengdu, Sichuan, 610041 China
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Chao Huang
College of Chemistry, Sichuan University, Chengdu, Sichuan, 610041 China
Correspondence to: C. Huang; e-mail: [email protected] J. Wang; e-mail: [email protected] X. Pei; e-mail: [email protected]Search for more papers by this authorHe Cai
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorShanshan Hu
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorQianbing Wan
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorCorresponding Author
Xibo Pei
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Correspondence to: C. Huang; e-mail: [email protected] J. Wang; e-mail: [email protected] X. Pei; e-mail: [email protected]Search for more papers by this authorCorresponding Author
Jian Wang
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Correspondence to: C. Huang; e-mail: [email protected] J. Wang; e-mail: [email protected] X. Pei; e-mail: [email protected]Search for more papers by this authorJunyu Chen
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
These authors contributed equally to this work.
Search for more papers by this authorXin Zhang
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
College of Chemistry, Sichuan University, Chengdu, Sichuan, 610041 China
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Chao Huang
College of Chemistry, Sichuan University, Chengdu, Sichuan, 610041 China
Correspondence to: C. Huang; e-mail: [email protected] J. Wang; e-mail: [email protected] X. Pei; e-mail: [email protected]Search for more papers by this authorHe Cai
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorShanshan Hu
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorQianbing Wan
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorCorresponding Author
Xibo Pei
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Correspondence to: C. Huang; e-mail: [email protected] J. Wang; e-mail: [email protected] X. Pei; e-mail: [email protected]Search for more papers by this authorCorresponding Author
Jian Wang
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Correspondence to: C. Huang; e-mail: [email protected] J. Wang; e-mail: [email protected] X. Pei; e-mail: [email protected]Search for more papers by this authorAbstract
As a new class of crystalline nanoporous materials, metal-organic frameworks (MOFs) have recently been used for biomedical applications due to their large surface area, high porosity, and theoretically infinite structures. To improve the biological performance of titanium, MOF films were applied to surface modification of titanium. Zn-based MOF films composed of zeolitic imidazolate framework-8 (ZIF-8) crystals with nanoscale and microscale sizes (nanoZIF-8 and microZIF-8) were prepared on porous titanium surfaces by hydrothermal and solvothermal methods, respectively. The ZIF-8 films were characterized by powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The nanoZIF-8 film exhibited good biocompatibility, whereas the microZIF-8 film showed obvious cytotoxicity to MG63 cells. Compared to pure titanium and alkali- and heat-treated porous titanium, the nanoZIF-8 film not only enhanced alkaline phosphatase (ALP) activity, extracellular matrix mineralization, and expression of osteogenic genes (ALP, Runx2) in MG63 cells but also inhibited the growth of Streptococcus mutans. These results indicate that MOF films or coatings may be promising candidates for bone tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 834–846, 2017.
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