Original Article
The effect of hydroxyapatite in biopolymer-based scaffolds on release of naproxen sodium
Vahid Asadian-Ardakani,
Samaneh Saber-Samandari,
Saeed Saber-Samandari,
Vahid Asadian-Ardakani
Materials and Biomaterials Research Center, Tehran, Iran
Search for more papers by this authorCorresponding Author
Samaneh Saber-Samandari
Department of Chemistry, Eastern Mediterranean University, Gazimagusa, 10 TRNC via Mersin, Turkey
Correspondence to: S. Saber-Samandari; e-mail: [email protected] or S. Saber-Samandari; e-mail: [email protected]Search for more papers by this authorCorresponding Author
Saeed Saber-Samandari
New Technologies Research Center, Amirkabir University of Technology, Tehran, Iran
Correspondence to: S. Saber-Samandari; e-mail: [email protected] or S. Saber-Samandari; e-mail: [email protected]Search for more papers by this authorVahid Asadian-Ardakani,
Samaneh Saber-Samandari,
Saeed Saber-Samandari,
Vahid Asadian-Ardakani
Materials and Biomaterials Research Center, Tehran, Iran
Search for more papers by this authorCorresponding Author
Samaneh Saber-Samandari
Department of Chemistry, Eastern Mediterranean University, Gazimagusa, 10 TRNC via Mersin, Turkey
Correspondence to: S. Saber-Samandari; e-mail: [email protected] or S. Saber-Samandari; e-mail: [email protected]Search for more papers by this authorCorresponding Author
Saeed Saber-Samandari
New Technologies Research Center, Amirkabir University of Technology, Tehran, Iran
Correspondence to: S. Saber-Samandari; e-mail: [email protected] or S. Saber-Samandari; e-mail: [email protected]Search for more papers by this authorAbstract
A scaffold capable of controlling drug release is highly desirable for bone tissue engineering. The objective of this study was to develop and characterize a highly porous biodegradable scaffold and evaluate the kinetic release behavior for the application of anti-inflammatory drug delivery. Porous scaffolds consisting of chitosan, poly(acrylic acid), and nano-hydroxyapatite were prepared using the freeze-drying method. The nanocomposite scaffolds were characterized for structure, pore size, porosity, and mechanical properties. The nanocomposite scaffolds were tested and characterized using Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy-dispersive analysis of X-ray (EDS), X-ray diffraction (XRD) analysis, and tensile test instrument. The results showed that the pores of the scaffolds were interconnected, and their sizes ranged from 145 µm to 213 μm. The mechanical properties were found close to those of trabecular bone of the same density. The ability of the scaffolds to deliver naproxen sodium as a model drug in vitro was investigated. The release profile of naproxen sodium was measured in a phosphate-buffered saline solution by a ultra-violet spectrophotometer that was controlled by the Fickian diffusion mechanism. These results indicated that the chitosan-graft-poly(acrylic acid)/nano-hydroxyapatite scaffold may be a promising biomedical scaffold for clinical use in bone tissue engineering with a potential for drug delivery. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2992–3003, 2016.
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