Multiwalled carbon nanotube-modified poly(d,l-lactide-co-glycolide) scaffolds for dendritic cell load
Yanzhu Yang
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240 People's Republic of China
These authors contributed equally to this work.
Search for more papers by this authorSanyuan Shi
School of Biomedical Engineering/Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China
These authors contributed equally to this work.
Search for more papers by this authorQian Ding
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240 People's Republic of China
Search for more papers by this authorJian Chen
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240 People's Republic of China
Search for more papers by this authorCorresponding Author
Jinliang Peng
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240 People's Republic of China
School of Biomedical Engineering/Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China
Correspondence to: Dr. Y. Xu; e-mail: [email protected] or Dr. J. Peng; e-mail: [email protected]Search for more papers by this authorCorresponding Author
Yuhong Xu
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240 People's Republic of China
School of Biomedical Engineering/Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China
Correspondence to: Dr. Y. Xu; e-mail: [email protected] or Dr. J. Peng; e-mail: [email protected]Search for more papers by this authorYanzhu Yang
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240 People's Republic of China
These authors contributed equally to this work.
Search for more papers by this authorSanyuan Shi
School of Biomedical Engineering/Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China
These authors contributed equally to this work.
Search for more papers by this authorQian Ding
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240 People's Republic of China
Search for more papers by this authorJian Chen
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240 People's Republic of China
Search for more papers by this authorCorresponding Author
Jinliang Peng
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240 People's Republic of China
School of Biomedical Engineering/Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China
Correspondence to: Dr. Y. Xu; e-mail: [email protected] or Dr. J. Peng; e-mail: [email protected]Search for more papers by this authorCorresponding Author
Yuhong Xu
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240 People's Republic of China
School of Biomedical Engineering/Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China
Correspondence to: Dr. Y. Xu; e-mail: [email protected] or Dr. J. Peng; e-mail: [email protected]Search for more papers by this authorAbstract
Poly(d,l-lactide-co-glycolide) (PLGA) is widely used in a variety of tissue engineering and drug delivery applications due to its biodegradability and biocompatibility. But PLGA surfaces are usually hydrophobic which limited the loading and seeding capacities for cells, especially semiadherent immune cells. In this paper we described an attempt to improve the hydrophilicity and surface architecture for accommodating dendritic cells (DCs) that are widely used as professional antigen presenting cells in immune therapy of cancer and other diseases. The 3D porous PLGA scaffold was made by solvent casting/salt leaching of PLGA blended with surface functionalized multiwalled carbon nanotubes (F-MWCNTs). The incorporation and dispersion of F-MWCNT in the scaffold structures resulted in not only improved surface hydrophilicity but also nanoscale surface structure that would provide a preferable microenvironment for DCs attachment. We think such a scaffold material may be more desirable for immune cell delivery for immunotherapy. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1045–1052, 2015.
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