Synthesis of amphiphilic poly(tetraethylene glycol succinate) and the thermosensitivity of its aggregation in water
Shusen Chen
Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemistry, Department of Chemistry, Nankai University, Tianjin 300071, China
Search for more papers by this authorYinong Wang
Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemistry, Department of Chemistry, Nankai University, Tianjin 300071, China
Search for more papers by this authorYunge Fan
Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemistry, Department of Chemistry, Nankai University, Tianjin 300071, China
Search for more papers by this authorCorresponding Author
Jianbiao Ma
School of Chemistry and Chemical Engineering, Tianjin University of Technology, 263 South Hongqi Road, Tianjin 300191, China
School of Chemistry and Chemical Engineering, Tianjin University of Technology, 263 South Hongqi Road, Tianjin 300191, ChinaSearch for more papers by this authorShusen Chen
Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemistry, Department of Chemistry, Nankai University, Tianjin 300071, China
Search for more papers by this authorYinong Wang
Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemistry, Department of Chemistry, Nankai University, Tianjin 300071, China
Search for more papers by this authorYunge Fan
Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemistry, Department of Chemistry, Nankai University, Tianjin 300071, China
Search for more papers by this authorCorresponding Author
Jianbiao Ma
School of Chemistry and Chemical Engineering, Tianjin University of Technology, 263 South Hongqi Road, Tianjin 300191, China
School of Chemistry and Chemical Engineering, Tianjin University of Technology, 263 South Hongqi Road, Tianjin 300191, ChinaSearch for more papers by this authorAbstract
Amphiphilic biodegradable polyester, poly(tetraethylene glycol succinate) (PTEGSuc), was synthesized via melt polycondensation of tetraethylene glycol and succinic acid on catalysis of p-toluenesulfonic acid. It was observed that PTEGSuc could self-assemble into micelles in water. In addition, thermosensitivity of PTEGSuc aggregation in water was first found in the experiment, and the critical aggregation temperatures could be controlled by solution concentration. Transmission electron microscopy was used to investigate the micellar morphologies of PTEGSuc in different solvents. It was found that particle shape is almost round although the micellar morphology is different depending on the solvent used. Based on the perfect properties, especially in micelle formation and thermosensitivity, PTEGSuc is promising in biomedical field as carrier of drug delivery system, scaffold of tissue engineering, and other medical devices. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
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