Case Report
Cytomegalovirus Enterocolitis in an Immunocompetent Infant Host: Another Cause of Treatable Intractable Diarrhea in Infancy
Ruben E. Quiros-Tejeira,
Marvin E. Ament,
Teresa Rivera-Penera,
Galen Cortina,
Jorge H. Vargas,
Ruben E. Quiros-Tejeira
Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Los Angeles, California, U.S.A.
Search for more papers by this authorCorresponding Author
Marvin E. Ament
Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Los Angeles, California, U.S.A.
Address correspondence and reprint requests to Marvin E. Ament, MD, UCLA Medical Center, Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, 12-383 MDCC, 10833 Le Conte Avenue, Los Angeles CA, 90095-1752, U.S.A.Search for more papers by this authorTeresa Rivera-Penera
Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Los Angeles, California, U.S.A.
Search for more papers by this authorGalen Cortina
Department of Pathology, University of California at Los Angeles Medical Center, Los Angeles, California, U.S.A.
Search for more papers by this authorJorge H. Vargas
Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Los Angeles, California, U.S.A.
Search for more papers by this authorRuben E. Quiros-Tejeira,
Marvin E. Ament,
Teresa Rivera-Penera,
Galen Cortina,
Jorge H. Vargas,
Ruben E. Quiros-Tejeira
Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Los Angeles, California, U.S.A.
Search for more papers by this authorCorresponding Author
Marvin E. Ament
Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Los Angeles, California, U.S.A.
Address correspondence and reprint requests to Marvin E. Ament, MD, UCLA Medical Center, Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, 12-383 MDCC, 10833 Le Conte Avenue, Los Angeles CA, 90095-1752, U.S.A.Search for more papers by this authorTeresa Rivera-Penera
Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Los Angeles, California, U.S.A.
Search for more papers by this authorGalen Cortina
Department of Pathology, University of California at Los Angeles Medical Center, Los Angeles, California, U.S.A.
Search for more papers by this authorJorge H. Vargas
Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Los Angeles, California, U.S.A.
Search for more papers by this authorNo abstract is available for this article.
REFERENCES
- 1Cohen JI, Corey R. Cytomegalovirus infection in the normal host. Medicine 1985; 64: 100–14.
- 2Frenkel LD, Sunanda G, Tsolia M, Scudder R, Howell R, Kesarwala H. Cytomegalovirus infection in children with AIDS. Rev Infect Dis 1990; 12: S820–6.
- 3Katlama C. Cytomegalovirus infection in acquired immune-deficiency syndrome. J Med Virol 1993;Supplement 1: 128–33.
- 4Franzin G, Novelli P, Fratton A. Histologic evidence of cytomegalovirus in the duodenal and gastric mucosa of patients with renal allograft. Endoscopy 1980; 12: 117–20.
- 5Franzin G, Muolo A, Griminelli T. Cytomegalovirus inclusions in the gastroduodenal mucosa of patients after renal transplantation. Gut 1981; 22: 698–701.
- 6Schwartz DA, Wilcox M. Atypical cytomegalovirus inclusions in gastrointestinal biopsy specimens from patients with acquired immunodeficiency syndrome. Hum Pathol 1992; 23: 1019–26.
- 7Henson D, Siegel SE, Fuccillo DA, Matthew E, Levine AS. Cytomegalovirus infections during acute childhood leukemia. J Infect Dis 1972; 126: 469–81.
- 8Alexander JA, Cuellar RE, Fadden RJ, Genovese JJ, Gavaler JS, Van Thiel DH. Cytomegalovirus infection of the upper gastrointestinal tract before and after liver transplantation. Transplantation 1988; 46: 378–82.
- 9Ho M. Epidemiology of cytomegalovirus infections. Rev Infect Dis 1990; 12(Suppl): S701–10.
- 10Webster A, Lee CA, Cook DG et al. Cytomegalovirus infection and progression towards AIDS in haemophiliacs with human immunodeficiency virus infection. Lancet 1989; 2: 63–6.
- 11Tatum ET, Sun PC, Cohn DL. Cytomegalovirus vasculitis and colon perforation in a patient with acquired immunodeficiency syndrome. Pathology 1989; 21: 235–8.
- 12Culpepper-Morgan JA, Kotler DP, Scholes JV, Tierney AR. Evaluation of diagnostic criteria for mucosal cytomegalic inclusion disease in the acquired immune deficiency syndrome. Am J Gastroenterol 1987; 82: 1264–70.
- 13Hinnant KL, Rotterdam HZ, Bell ET, Tapper ML. Cytomegalovirus infection of the alimentary tract: A clinicopathological correlation. Am J Gastroenterol 1986; 81: 944–50.
- 14Cheung AN, Ng IO. Cytomegalovirus infection of the gastrointestinal tract in non-AIDS patients. Am J Gastroenterol 1993; 88: 1882–6.
- 15Spiegel JS, Schwab AD. Disseminated cytomegalovirus infection with gastrointestinal involvement. Am J Gastroenterol 1980; 73: 37–44.
- 16Henson D. Cytomegalovirus inclusion bodies in the gastrointestinal tract. Arch Pathol 1972; 93: 477–82.
- 17Goodgame RW, Genta RM, Estrada R, Demmler G, Buffone G. Frequency of positive tests for cytomegalovirus in AIDS patients: Endoscopic lesions compared with normal mucosa. Am J Gastroenterol 1993; 88: 338–43.
- 18Grundy JE. Virologic and pathogenetic aspects of cytomegalovirus infection. Rev Infect Dis 1990; 12(Suppl): S711–9.
- 19Avery GB, Villavicencio O, Lilly JR et al. Intractable diarrhea in early infancy. Pediatrics 1968; 41: 712–722.
- 20Riley HD. History of the cytomegalovirus. South Med J 1997; 90: 184–90.
- 21Surawicz CM, Meyerson D. Self-limited cytomegalovirus colitis in immunocompetent individuals. Gastroenterology 1988; 94: 194–9.
- 22Tajima T. An autopsy case of primary cytomegalic inclusion enteritis with remarkable hypoproteinemia. Acta Pathol Jpn 1974; 24: 151–62.
- 23Jonkhoff-Slok TW, Veenhoven RH, Graeff-Meeder ER, Buller HA. An immunocompetent infant with cow's milk allergy and cytomegalovirus colitis. Eur J Pediatr 1997; 156: 528–9.
- 24Clayton F, Klein EB, Kotler DP. Correlation of in situ hybridization with histology and viral culture in patients with acquired immunodeficiency syndrome with cytomegalovirus colitis. Arch Pathol Lab Med 1989; 113: 1124–6.
- 25Myerson D, Hackman RC, Nelson JA, Ward DC, McDougall JK. Widespread presence of histologically occult cytomegalovirus. Hum Pathol 1984; 15: 430–9.
- 26Goodgame RW. Gastrointestinal cytomegalovirus disease. Ann Intern Med 1993; 119: 924–35.
- 27Klemola E, Von Essen R, Wager O, Haltia K, Koivuniemi A, Salmi I. Cytomegalovirus mononucleosis in previously healthy individuals. Ann Intern Med 1969; 71: 11–9.
- 28Iwasaki T. Alimentary tract lesions in cytomegalovirus infection. Acta Pathol Jpn 1987; 37: 549–565.
- 29Macasaet FF, Holley KE, Smith TF, Keys T. Cytomegalovirus studies of autopsy tissue. Am J Clin Pathol 1975; 63: 859–65.
- 30Chou S. Newer Methods for diagnosis of cytomegalovirus infection. Rev Infect Dis 1990; 12(Suppl): S727–36.
- 31Balfour HH. Management of cytomegalovirus disease with antiviral drugs. Rev Infect Dis 1990; 12(Suppl): S849–60.
- 32Demmler GJ. Cytomegalovirus. In: RD Feigin, JD Cherry, eds. Textbook of pediatric infectious diseases. Philadelphia: WB Saunders, 1998: 1732–51.
- 33Alford CA, Stagno S, Pass RF, Britt WJ. Congenital and perinatal cytomegalovirus infections. Rev Infect Dis 1990; 12(Suppl): S745–53.
- 34Stagno S. Cytomegalovirus. In: JS Remington, JO Klein, eds. Infectious diseases of the fetus and newborn infant. Philadelphia: WB Saunders, 1995: 312–53.
- 35Stagno S, Reynolds DW, Pass RF, Alford CA. Breast milk and the risk of cytomegalovirus infection. N Engl J Med 1980; 302: 1073–6.
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