Increased production of immune activation marker neopterin by colony-stimulating factors in gynecological cancer patients
Corresponding Author
Christian Marth
Department of Obstetrics and Gynecology, University of Innsbruck, Innsbruck, Austria
Department of Obstetrics and Gynecology, University Hospital, Anich-strasse 35, A-6020 Innsbruck, Austria. Fax: 43 512 504 3112Search for more papers by this authorGünther Weiss
Internal Medicine, University Hospital, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorAstrid Koza
Department of Obstetrics and Gynecology, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorGilbert Reibnegger
Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorGünter Daxenbichler
Department of Obstetrics and Gynecology, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorAlain G. Zeimet
Department of Obstetrics and Gynecology, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorDietmar Fuchs
Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorHelmut Wachter
Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorOtto Dapunt
Department of Obstetrics and Gynecology, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorCorresponding Author
Christian Marth
Department of Obstetrics and Gynecology, University of Innsbruck, Innsbruck, Austria
Department of Obstetrics and Gynecology, University Hospital, Anich-strasse 35, A-6020 Innsbruck, Austria. Fax: 43 512 504 3112Search for more papers by this authorGünther Weiss
Internal Medicine, University Hospital, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorAstrid Koza
Department of Obstetrics and Gynecology, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorGilbert Reibnegger
Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorGünter Daxenbichler
Department of Obstetrics and Gynecology, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorAlain G. Zeimet
Department of Obstetrics and Gynecology, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorDietmar Fuchs
Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorHelmut Wachter
Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorOtto Dapunt
Department of Obstetrics and Gynecology, University of Innsbruck, Innsbruck, Austria
Search for more papers by this authorAbstract
Granulocyte colony-stimulating factor (G-CSF) and granulo-cyte-macrophage colony-stimulating factor (GM-CSF) have recently been introduced in the treatment of chemotherapy-induced neutropenia. Effects of these CSFs on the cellular immune system were evaluated in 38 neutropenic gynecological cancer patients during chemotherapy. In addition to restoring the leukocyte count, GM-CSF-to a greater extent than G-CSF—also induced neopterin, a sensitive marker of macro-phages activated by interferons. This effect was confirmed in vitro by investigating the effects of these CSFs on interferon-γ-mediated pathways in THP-1 human myelomonocytic cells. The results suggest activation of immune effector cells by GM-CSF. © 1994 Wiley-Liss, Inc.
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