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SCLC-cluster-2 antibodies detect the pancarcinoma/epithelial glycoprotein EGP-2
Lou De Leij,
Wijnand Helrich,
Rhona Stein,
M. Jules Mattes,
Lou De Leij
Departments of Clinical Immunology, University Hospital Groningen, Oostersingel 59, 9713 EZ Groningen, The Netherlands
Search for more papers by this authorWijnand Helrich
Departments of Clinical Immunology, University Hospital Groningen, Oostersingel 59, 9713 EZ Groningen, The Netherlands
Search for more papers by this authorRhona Stein
Center for Molecular Medians and Immunology, Newark, NJ, USA
Search for more papers by this authorM. Jules Mattes
Center for Molecular Medians and Immunology, Newark, NJ, USA
Search for more papers by this authorLou De Leij,
Wijnand Helrich,
Rhona Stein,
M. Jules Mattes,
Lou De Leij
Departments of Clinical Immunology, University Hospital Groningen, Oostersingel 59, 9713 EZ Groningen, The Netherlands
Search for more papers by this authorWijnand Helrich
Departments of Clinical Immunology, University Hospital Groningen, Oostersingel 59, 9713 EZ Groningen, The Netherlands
Search for more papers by this authorRhona Stein
Center for Molecular Medians and Immunology, Newark, NJ, USA
Search for more papers by this authorM. Jules Mattes
Center for Molecular Medians and Immunology, Newark, NJ, USA
Search for more papers by this authorAbstract
Analysis of the antibodies submitted to the 3 International Workshops on Small Cell Lung Cancer Antigens has resulted in the identification of 15 clusters of antibody reactivity. One of these clusters, named SCLC cluster 2, is characterized by reactivity against an epithelium-associated 38 kDa membrane glycoprotein. SCLC cluster 2, and a number of other antibodies with reportedly similar reactivities, were shown to recognize a protein encoded by the GA733-2 gene, whereas the newly defined SCLC cluster 13 antibodies react with the GA733-1 gene product. We propose to call the antigen detected by SCLC-duster-2 antibodies “epithelial glycoprotein 2” (EGP-2), and the epithelium-associated glycoprotein recognized by antibodies clustered in SCLC cluster 13 (see elsewhere in this volume) “epithelial glycoprotein 1” (EGP-1). A short overview of the characteristics of both proteins and the applications of and-EGP-2 antibodies is presented.
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