Novel subsets of human T cells (CD4+ CD8+ TCRγδ and CD4− CD8− TCRαβ) and T-cell development
Jack L. Strominger
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138; and the Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Search for more papers by this authorMarina Fabbi
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138; and the Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Search for more papers by this authorMargaret Prendergast
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138; and the Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Search for more papers by this authorRichard T. Maziarz
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138; and the Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Search for more papers by this authorSteven J. Burakoff
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138; and the Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Search for more papers by this authorVeronika Groh
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138; and the Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Search for more papers by this authorJack L. Strominger
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138; and the Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Search for more papers by this authorMarina Fabbi
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138; and the Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Search for more papers by this authorMargaret Prendergast
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138; and the Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Search for more papers by this authorRichard T. Maziarz
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138; and the Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Search for more papers by this authorSteven J. Burakoff
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138; and the Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Search for more papers by this authorVeronika Groh
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138; and the Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Search for more papers by this authorAbstract
The discovery of human cells expressing TCRγδ, the genes which encode it and the TCRγδ proteins which are expressed (Quertermous et al., 1986a,b; Dialynas et al., 1986; Brenner et al., 1986, 1988; Satyanarayana et al., 1988; Hochstenbach et al., 1988).
References
- Brenner, M. B., McLean, J., Dialynas D. P., Strominger, J. L., Smith, J. A., Owen, F. L., Seidman, J. G., Ip S., Rosen, F. and Krangel, M., Identification of a putative second T-cell receptor. Nature (Lond.), 322, 145–149 (1986).
- Brenner, M. B., Strominger, J. L. and Krangel, M. S., The γδ T-cell receptor. In: F. J. Dixon (ed.), Advances in immunology, Vol. 34, pp. 133–192, Academic Press. New York (1988).
- Dialynas, D. P., Murre. C., Quertermous, T., Boss, J. M., Leiden, J. M., Seidman, J. G. and Strominger, J. L., Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell γ chain. Proc. nat. Acad. Sci. (Wash.). 83, 2619–2623 (1986).
- Fabbi, M., Groh, V. and Strominger, J. L., Lymphokine requirements of human CD4−CD8− thymocytes. FASEB J., 3, A1108 (1989) and Proc. nat. Acad. Sci. (Wash.), in press (1989).
- Groh, V., Fabbi, M., Hochstenbach, F., Maziarz, R. and Strominger, J. L., “Double negative” (CD4−CD8−) lymphocytes bearing T-cell receptor αβ in normal human skin. Proc. nat. Acad. Sci. (Wash.), in press (1989a).
- Groh, V., Porcelli, S., Fabbi, M., Lanier, L. L., Picker, L. J., Anderson, T., Warnke, R. A., Bhan, A. K., Strominger, J. L. and Brenner, M. B., Human lymphocytes bearing TCRγδ are phenotypically diverse and evenly distributed throughout the lymphoid system. J. exp. Med., 169, 1277–1294 (1989b).
- Hochstenbach, F., Parker. C., McLean, J., Gieselman, V., Band, H., Bank, I., Chess, L., Spits, H., Strominger, J. L., Seidman, J. G. and Brenner, M. B., Characterization of a third form of the human T-cell receptor γδ. J. exp. Med., 168, 761–766 (1988).
- Maziarz, R. T., Groh, V., Prendergast, M., Fabbi, M., Strominger, J. L. and Burakoff, S. J., Non-MHC-restricted target cell lysis by several αβ and γδ T cell lines results from lymphokine activated killing. Abstract, 7th International Congress of Immunology, Berlin, FRG (1989).
- Quertermous, T., Murre, C., Dialynas, D., Duby, A., Strominger, J., Waldmann, T. and Seidman, J. G., Human T-cell γ genes: organization, diversity and rearrangement. Science, 231, 252–255 (1986a).
- Quertermous, T., Strauss, W., Murre, C., Dialynas, D., Strominger, J. L. and Seidman. J. G., Human γ genes have marked junctional variability due to N segments. Nature (Lond.), 322, 184–187 (1986b).
- Satyanarayana, K., Hata, S., Devlin, P., Roncarlo, M. G., De Vries, J. E., Spits, H., Strominger, J. L. and Krangel, M. S., Genomic organization of the human T-cell antigen-receptor αβ locus. Proc. nat. Acad. Sci. (Wash.), 85, 8166–8170 (1988).
- Strominger, J. L., The γδ T-cell receptor and class Ib major histocompatibility complex proteins: enigmatic molecules of immune recognition. Cell, in press (1989a).
- Strominger, J. L., Development biology of T-cell receptors. Science (in press) (1989b).
