Human Cancer
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Membrane fluidity affects tumor-cell motility, invasion and lung-colonizing potential
Giulia Taraboletti,
Lianna Perin, Barbara Bottazzi, Alberto Mantovani, Raffaella Giavazzi,
Mario Salmona,
Corresponding Author
Giulia Taraboletti
Istituto di Ricerche Farmacologiche Mario Negri, Via Gavazzeni, 11, 24100 Bergamo
Istituto di Rieerehe Farmacologiche Mario Negri, Via Gavazzeni 11, 24100 Bergamo, ItalySearch for more papers by this authorRaffaella Giavazzi
Istituto di Ricerche Farmacologiche Mario Negri, Via Gavazzeni, 11, 24100 Bergamo
Search for more papers by this authorGiulia Taraboletti,
Lianna Perin, Barbara Bottazzi, Alberto Mantovani, Raffaella Giavazzi,
Mario Salmona,
Corresponding Author
Giulia Taraboletti
Istituto di Ricerche Farmacologiche Mario Negri, Via Gavazzeni, 11, 24100 Bergamo
Istituto di Rieerehe Farmacologiche Mario Negri, Via Gavazzeni 11, 24100 Bergamo, ItalySearch for more papers by this authorRaffaella Giavazzi
Istituto di Ricerche Farmacologiche Mario Negri, Via Gavazzeni, 11, 24100 Bergamo
Search for more papers by this authorAbstract
Membrane fluidity, determined by steady-state fluorescence polarization measurements, was correlated with metastatic capacity of murine tumor-cell lines. A correlation was observed in cell lines with different metastatic potential, and was confirmed when their lung-colonizing ability was modulated by alteration of either the membrane lipid composition or the culture conditions. Two cellular functions, motility and basement membrane invasion, were affected by the membrane lipid composition, and might explain the role of membrane fluidity observed in cancer metastasis.
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