Human Cancer
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Suppression of c-myc mRNA expression by steroid hormones in HTLV-I-infected T-cell line, KH-2
Tamio Koizumi,
Yoshinobu Nakao,
Michiko Kawanishi,
Sakan Maeda,
Taketoshi Sugiyama,
Takuo Fujita,
Tamio Koizumi
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650
Search for more papers by this authorCorresponding Author
Yoshinobu Nakao
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650Search for more papers by this authorMichiko Kawanishi
Department of Medical Microbiology, Faculty of Medicine, Kyoto University, Kyoto
Search for more papers by this authorSakan Maeda
The Second Department of Pathology, Kobe University School of Medicine, Kobe 650, Japan
Search for more papers by this authorTaketoshi Sugiyama
The Second Department of Pathology, Kobe University School of Medicine, Kobe 650, Japan
Search for more papers by this authorTakuo Fujita
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650
Search for more papers by this authorTamio Koizumi,
Yoshinobu Nakao,
Michiko Kawanishi,
Sakan Maeda,
Taketoshi Sugiyama,
Takuo Fujita,
Tamio Koizumi
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650
Search for more papers by this authorCorresponding Author
Yoshinobu Nakao
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650Search for more papers by this authorMichiko Kawanishi
Department of Medical Microbiology, Faculty of Medicine, Kyoto University, Kyoto
Search for more papers by this authorSakan Maeda
The Second Department of Pathology, Kobe University School of Medicine, Kobe 650, Japan
Search for more papers by this authorTaketoshi Sugiyama
The Second Department of Pathology, Kobe University School of Medicine, Kobe 650, Japan
Search for more papers by this authorTakuo Fujita
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650
Search for more papers by this authorAbstract
The effects of l,25(OH)2D3 and dexamethasone on cellular proliferation and gene expression of the HTLV-l-infected T-cell line, KH-2, established from a patient with adult T-cell leukemia, endemic in the south-west Japanese islands and the Caribbean, were examined. KH-2 cells are integrated by HTLV-I proviral DNA and expressed mRNA for c-myc, IL-2 receptor a-chain (IL-2Rα), and T-cell receptor β-chain (TCRβ) while it did not express IL-2 mRNA. l,25(OH)2D3 and dexamethasone did not suppress the mRNA levels of HTLV-I, IL-2Rα or TCRβ but reduced the c-myc mRNA level. The reduction of c-myc mRNA level was marked in l,25(OH)2D3-treated cells but relatively weak in dexamethasone-treated cells. This inhibitory effect of the steroid hormones correlated with the inhibition of KH-2 cell proliferation.
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