Experimental Cancer
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Anti-tumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant friend leukemia cells. V. Comparisons with the action of tumor necrosis factor
I. Gresser,
F. Belardelli, J. Tavernier, W. Fiers, F. Podo, M. Federico, G. Carpinelli, P. Duvillard, M. Prade, C. Maury,
M.-T. Bandit,
M.-T. Maunoury,
I. Gresser
Institut de Recherches Scientifiques sur le Cancer, Villejuif, France
Search for more papers by this authorC. Maury
Institut de Recherches Scientifiques sur le Cancer, Villejuif, France
Search for more papers by this authorM.-T. Bandit
Institut de Recherches Scientifiques sur le Cancer, Villejuif, France
Search for more papers by this authorM.-T. Maunoury
Institut de Recherches Scientifiques sur le Cancer, Villejuif, France
Search for more papers by this authorI. Gresser,
F. Belardelli, J. Tavernier, W. Fiers, F. Podo, M. Federico, G. Carpinelli, P. Duvillard, M. Prade, C. Maury,
M.-T. Bandit,
M.-T. Maunoury,
I. Gresser
Institut de Recherches Scientifiques sur le Cancer, Villejuif, France
Search for more papers by this authorC. Maury
Institut de Recherches Scientifiques sur le Cancer, Villejuif, France
Search for more papers by this authorM.-T. Bandit
Institut de Recherches Scientifiques sur le Cancer, Villejuif, France
Search for more papers by this authorM.-T. Maunoury
Institut de Recherches Scientifiques sur le Cancer, Villejuif, France
Search for more papers by this authorAbstract
A number of similarities and dissimilarities in the anti-tumor effects of TNF and interferon α/β have been observed in DBA/2 mice injected with Friend erythroleukemia cells (FLC). Mouse TNF exerted marked anti-tumor effects in mice injected either s.c. or i.p. with FLC lines 3C 18 or 3 γR8 resistant in vitro to the cytotoxic effects of TNF. Likewise, mouse interferon α/β had anti-tumor activity in mice injected with these FLC, resistant to the action of interferon α/β or γ in vitro. The results of histopathologic examination and 31P nuclear magnetic resonance analyses of 3C18 FLC s.c. tumors injected with TNF resembled the results previously obtained for 3C18 FLC tumors injected with interferon α/β, although the effects of TNF occurred more rapidly. Injection of mice with antibody to mouse interferon α/β or γ did not abrogate the anti-tumor effects of TNF in mice injected i.p. with FLC. Our results suggest that in this experimental system the anti-tumor effects of TNF, like interferon α/β, do not result from a direct effect on the tumor cells themselves but are host-mediated.
References
- Affabris, E., Jemma, C., and Rossi, G. B., Isolation of inter-feron-resistant variants of Friend erythroleukemia cells: effect of interferon and ouabain. Virology, 120, 441–452 (1982).
- Amici, C., Fekrantini, M., Benedetto, A., Belardelli, F., and Gresser, I., Biologic and biochemical differences between in vitro and in vivo passaged Friend erythroleukemia cells. II. Changes in cell surface glycoproteins associated with a highly malignant phenotype. Int. J. Cancer, 34, 397–402 (1984).
- Balkwill, F. R., Lee, A., Aldam, G., Moodie, E., Thomas, J A, Tavernier, J., and Fiers, W., Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons. Int. J Cancer, in press (1986).
- Belardelli, F., Ferrantini, M., Maury, C., Santurbano, L., and Gresser, I., Biologic and biochemical differences between in vitro and in vivo passaged Friend erythroleukemia cells. I. Tumorigenicity and capacity to metastasize. Int. J. Cancer, 34, 389–395 (1984).
- Belardelli, F., Gresser, I., Maury, C., Duvillaid, P., Prade, M., and Maunoury, M. T., Anti-tumor effects cf interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcutaneously. Int. J. Cancer, 31, 649–653 (1983).
- Belardelli, F., Gresser, I., Maury, C., and Maunoury, M. T., Anti-tumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. I. Int. J. Cancer, 30, 813–820 (1982a).
- Belardelli, F., Gresser, I., Maury, C., and Maunoury, M. T., Anti-tumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. II. Role of host mechanisms. Int. J. Cancer, 30, 821–825 (1982b).
- Brady, T. J., Burt, C. T., Goldman, M. R., Pykett, I. L., Buonanno, F. S., Kistler, J. P., Newhouse, J. H., Hinshaw, W. S., and Pohost, G. M., Tumor characterization using 31P-NMR spectroscopy. In: NMR Imaging. Proceedings of an International Symposium held at the Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina, October 1–3, pp. 175–180 (1981).
- Brouckaert, P., Leroux, G., and Fiers, W., Effect of rRNF, administered alone or in combination with IFN-γ in the mouse system (in vivo). Personal communication (1986).
- Carpinelli, G., Podo, F., Di Vito, M., Proietti, E., Gessani, S., and Belardelli, F., Modulations of glycerophosphorylcho-line and phosphorylcholine in Friend erythroleukemia cells upon in vitro-induced erythroid differentiation: a 31P-NMR study. FEBS Lett., 176, 88–92 (1984).
- Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., and Williamson, B., An endotoxin-induced serum factor that causes necrosis of tumors. Proc. nat. Acad. Sci. (Wash.), 72, 3666–3670 (1975).
- Collins, T., Lapierre, L. A., Fiers, W., Strominger, J. J., and Pober, J. S., Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A, B antigens in vascular endothelial cells and dermal fibroblasts in vitro. Proc. nat. Acad. Sci. Wash., 83, 446–450 (1986).
- Evanochko, W. T., Ng, T. C., Lilly, M. B., Lawson, A. J., Corbett, T. H., Durant -J. R., and Glickson, J. D., In vivo 31P-NMR study of the metabolism of murine mammary 16/C adeno-carcinoma and its response to chemotherapy, X-radiation and hyperthermia. Proc. nat. Acad. Sci. (Wash.), 80, 334–338 (1983).
- Fransen, L., Mueller, R., Marmenout, A., Tavernier, J., Van Der Heyden, J., Kawashima, E., Chollet, A., Tizard, R., Van Heuverswyn, H., Van Vliet, A., Ruysschaert, M. R., and Fiers, W., Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor. Nucl. Acid Res., 13, 4417–4429 (1985).
- Fransen, L., Van Der Heyden, J., Ruysschaert, M. R., and Fiers, W., Recombinant tumor necrosis factor: its effects and its synergism with interferon-γ on a variety of normal and transformed human cell lines. Europ. J. Cancer clin. Oncol., in press (1986).
- Green, S., Dobrjansky, A., Carswell, E. A., Kassel, R. L., Old, L. J., Fiore, N., and Schwartz, M. K., Partial purification of a serum factor that causes necrosis of tumors. Proc. nat. Acad. Sci. (Wash.), 73, 381–385 (1976).
- Gresser, I., Can interferon induce disease? In: I. Gresser (ed.), Interferon 4, pp. 95–127, Academic Press, London (1982).
- Gresser, I., How does interferon inhibit tumor growth? In: I. Gresser (ed.), Interferon 6, pp. 93–126, Academic Press, London (1985).
- Gresser, I., Tovey, M. G., Bandu, M. T., Maury, C., and Brouty-Boyé, D., Role of interferon in the pathogenesis of virus disease in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. J. exp. Med., 144, 1305–1315 (1976).
- Haranaka, K., and Satomi, N., Cytotoxic activity of tumor necrosis factor (TNF) on the human cancer cells in vitro. Jap. J. exp. Med., 51, 191–194 (1981).
- Haranaka, K., Satomi, N., and Sakurai, A., Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice. Int. J. Cancer, 34, 263–267 (1984).
- Haranaka, K., Satomi, N., Sakurai, A., and Nariuchi, H., Purification and partial amino acid sequence of rabbit tumor necrosis factor. Int. J. Cancer, 36, 395–400 (1985).
- Helson, L., Helson, C., and Green, S., Effects of murine tumour necrosis factor on cultured human melanoma cells. Nature (Lond.), 258, 731–732 (1975).
- Helson, L., Helson, C., and Green, S., Effects of murine tumor necrosis factor on heterotransplanted human tumors. Exp Cell Biol., 47, 53–60 (1979).
- MäNnel, D. N., Moore, R. N., and Mergenhagen, S. E., Mac-rophages as a source of tumoricidal activity (tumor necrotizing factor). Infect. Immun., 30, 523–530 (1980).
- Marmenout, A., Fransen, L., Tavernier, J., Van Der Heyden, J., Tizard, R., Kawashima, E., Shaw, A., Johnson, M. J., Semon, D., Muller, R., Ruysschaert, M. R., Van Vliet, A., and Fiers, W., Molecular cloning and expression of human necrosis factor and comparison with mouse tumor necrosis factor. Europ. J. Biochem., 152, 515–522 (1985).
- Matthews, N., and Watkins, J. F., Tumour-necrosis factor from the rabbit. I. Mode of action, specificity and physiochemical properties. Brit. J. Cancer, 38, 302–309 (1978).
- Navon, G., Navon, R., Shulman, R. G., and Yamane, T., Phosphate metabolites in lymphoid Friend erythroleukemia and HeLa cells observed by high-resolution 31P-nuclear magnetic resonance. Proc. nat. Acad. Sci. (Wash.), 75, 891–895 (1978).
- Nawroth, P. P., and Stern, D. M., Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J. exp. Med., 163, 740–745 (1986).
- Old, J. L., Tumor necrosis factor (TNF). Science, 230, 630–632 (1985).
- Proietti, E., Carpinelli, G., Di Vito, M., Belardelli, F., Gresser, I., and Podo, E., 31P-nuclear magnetic resonance analysis of interferon-induced alterations of phospholipid metabolites in interferon-sensitive and interferon-resistant Friend leukemia cell tumors in mice. Cancer Res., 46, 2849–2857 (1986).
- Roberts, J. K. M., Wade-Jardetzky, N., and Jardetzky, O., Intracellular pn measurements by 31P-nuclear magnetic resonance. Influence of factors other man pH on 31P chemical shifts. Biochemistry, 20, 5389–5394 (1981).
- Romeo, G., Affabris, E., Federico, M., Mechti, N., Coccia, E. M., Jemma, C., and Rossi, G. B., Establishment of the antiviral state in α,β interferon-resistant Friend cells treated with γ interferon. J. biol. Chem., 260, 3833–3838 (1985).
- Sostman, H. D., Armitage, I. M., and Fisher, J. J., NMR in cancer. I. High resolution spectroscopy of tumors. Magn. Reson. Imag., 2, 265–278 (1984).
- Spitalny, G. L., and Havell, E. A., Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities. J. exp. Med., 159, 1560–1565 (1984).
- Stolpen, A. H., Guinan, E. C., Fiers, W., and Pober, J. S., Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers. Am. J. Path., 123, 16–24 (1986).
- Strander, H., Interferon treatment of human neoplasias. Advanc. Cancer Res., 46, 1–248 (1986).
- Taylor-Papadimitriou, J., Effects of interferon on cell growth and function. In: A. Billiau (ed.), Interferon: general and applied aspects, Vol. 1, 139–159, Elsevier, Amsterdam (1984).
- Tovey, M. G., Begon-Lours, J., and Gresser, I., A method for the large scale production of potent interferon preparations. Proc. Soc. exp. Biol. (N. Y.), 146, 809–815 (1974).
- Van Der Heyden, J., Fransen, L., and Fiers, W., Treatment of murine α/β sensitive and resistant Friend leukemia cells (FLC) with tumor necrosis factor (TNF) in combination with type-I or type-II murine interferon. In press (1986).
- Vilček, J., Henriksen-Destefano, D., Palombella, V. J., and Tsujimoto, M., Interactions between tumor necrosis factor and interferon. In: W. E. Stewart and H. Schellekens (eds.), The biology of the interferon system, pp. 249–255, Elsevier Science Publishers Amsterdam, New York, Oxford (1986).
- Wallach, D., Cytotoxins (tumor necrosis factor, lymphotoxin and others): molecular and functional characteristics and interactions with interferons. In: I. Gresser (ed.), Interferon 7, Academic Press, London (in press) (1986).
- Williamson, B. D., Carswell, E. A., Rubin, B. Y., Prendergast, J. S., and Old, L. J., Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon. Proc. nat. Acad. Sci. (Wash.), 80, 5397–5401 (1983).
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