Trends in mortality from leukemia in Europe: An update to 2009 and a projection to 2012
Paola Bertuccio
Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Department of Occupational Health, Università degli Studi di Milano, Milan, Italy
Search for more papers by this authorCorresponding Author
Cristina Bosetti
Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Tel.: +39-023901.4526, Fax: +39-0233200231
Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri," Via Giuseppe La Masa 19, 20156 Milan, ItalySearch for more papers by this authorMatteo Malvezzi
Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Department of Occupational Health, Università degli Studi di Milano, Milan, Italy
Search for more papers by this authorFabio Levi
Cancer Epidemiology Uint, Institute of social and preventive medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland
Search for more papers by this authorLiliane Chatenoud
Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Search for more papers by this authorEva Negri
Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Search for more papers by this authorCarlo La Vecchia
Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Department of Occupational Health, Università degli Studi di Milano, Milan, Italy
Search for more papers by this authorPaola Bertuccio
Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Department of Occupational Health, Università degli Studi di Milano, Milan, Italy
Search for more papers by this authorCorresponding Author
Cristina Bosetti
Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Tel.: +39-023901.4526, Fax: +39-0233200231
Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri," Via Giuseppe La Masa 19, 20156 Milan, ItalySearch for more papers by this authorMatteo Malvezzi
Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Department of Occupational Health, Università degli Studi di Milano, Milan, Italy
Search for more papers by this authorFabio Levi
Cancer Epidemiology Uint, Institute of social and preventive medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland
Search for more papers by this authorLiliane Chatenoud
Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Search for more papers by this authorEva Negri
Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Search for more papers by this authorCarlo La Vecchia
Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy
Department of Occupational Health, Università degli Studi di Milano, Milan, Italy
Search for more papers by this authorAbstract
We considered trends in mortality from leukemia in Europe over the period 1970–2009 using data from the World Health Organization. We computed age-standardized (world population) mortality rates, at all ages and in selected age groups, in 11 selected European countries, the European Union (EU) and, for comparative purposes, in the USA and Japan. For the EU, we also provided projections of the mortality to 2012. Over the period considered, mortality from leukemia steadily declined in most European countries in children and young adults, as well as in western and southern Europe at middle-age (45–69 years); in central/eastern Europe, reductions at ages 45–69 started since the mid-late 1990s. In the EU, annual percent changes were −3.7% in males and −3.8% in females at age 0–14, −2% in both sexes at age 15–44, and −0.6% in males and −1% in females at middle-age and overall. No decline was observed at age 70 or more. Between 1997 and 2007, overall EU rates decreased from 5.4 to 4.8/100,000 males and from 3.4 to 2.9/100,000 females. Declines were from 6.2 to 5.5/100,000 males and from 3.7 to 3.2/100,000 females in the USA and from 3.9 to 3.5/100,000 males and from 2.5 to 2.0/100,000 females in Japan. Projected overall rates in the EU at 2012 are 4.3/100,000 males (−11% compared to 2007) and 2.6/100,000 females (−12%).
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References
- 1 Kohler BA, Ward E, McCarthy BJ, et al. Annual report to the nation on the status of cancer, 1975–2007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst 2011; 103: 714–36.
- 2 Qiu D, Katanoda K, Marugame T, et al. A Joinpoint regression analysis of long-term trends in cancer mortality in Japan (1958–2004). Int J Cancer 2009; 124: 443–8.
- 3 Levi F, Lucchini F, Negri E, et al. Trends in mortality from leukemia in subsequent age groups. Leukemia 2000; 14: 1980–5.
- 4 Wayne AS, Reaman GH, Helman LJ. Progress in the curative treatment of childhood hematologic malignancies. J Natl Cancer Inst 2008; 100: 1271–3.
- 5 La Vecchia C, Bosetti C, Lucchini F, et al. Cancer mortality in Europe, 2000–2004, and an overview of trends since 1975. Ann Oncol 2010; 21: 1323–60.
- 6 Bosetti C, Bertuccio P, Chatenoud L, et al. Childhood cancer mortality in Europe, 1970–2007. Eur J Cancer 2010; 46: 384–94.
- 7 World Health Organization Statistical Information System. WHO mortality database Available at: http://www3.who.int/whosis/menu.cfm. Last accessed on April 2011.
- 8 World Health Organization. International Classification of Disease, 8th revision edn. Geneva: World Health Organization, 1967.
- 9 World Health Organization. International Classification of Disease, 9th revision edn. Geneva: World Health Organization, 1977.
- 10 World Health Organization. International statistical classification of disease and related health problems, 10th revision edn. Geneva: World Health Organization, 1992.
- 11 Doll R, Smith PG. Comparison between registries: age-standardized rates. vol. IV. IARC Sci Publ No. 42. In: JAH Waterhouse, CS Muir, K Shanmugaratnam, J Powell, D Peacham, S Whelan, eds. Cancer incidence in five continents. Lyon: IARC, 1982. 671–5.
- 12 National Cancer Institute. Joinpoint Regression Program, version 3.5. Available at: http://srab.cancer.gov/joinpoint. Last accessed on April 2011.
- 13 Kim HJ, Fay MP, Feuer EJ, et al Permutation tests for joinpoint regression with applications to cancer rates. (Erratum in: Stat Med 2001; 20: 655). Stat Med 2000; 19: 335–51.
- 14 Clegg LX, Hankey BF, Tiwari R, et al. Estimating average annual per cent change in trend analysis. Stat Med 2009; 28: 3670–82.
- 15 Malvezzi M, Arfé A, Bertuccio P, et al. European cancer mortality predictions for the year 2011. Ann Oncol 2010; 22: 947–56.
- 16 European Commission. Eurostat population database. Available at: http://epp.eurostat.ec.europa.eu/portal/portal/page/portal/eurostat/home/. Last accessed on October 2010.
- 17 Klepin HD, Balducci L. Acute myelogenous leukemia in older adults. Oncologist 2009; 14: 222–32.
- 18 Balducci L. The geriatric cancer patient: equal benefit from equal treatment. Cancer Control 2001; 8: 1–25; quiz 7–8.
- 19 Levi F, Lucchini F, Negri E, et al. Changed trends of cancer mortality in the elderly. Ann Oncol 2001; 12: 1467–77.
- 20 Juliusson G, Karlsson K, Lazarevic VLj, et al. Hematopoietic stem cell transplantation rates and long-term survival in acute myeloid and lymphoblastic leukemia: real-world population-based data from the Swedish Acute Leukemia Registry 1997–2006. Cancer 2011; 117: 4238–46.
- 21 Boyle P, Levin B. Leukaemias. In: P Boyle, B Levin, eds. World Cancer Report 2008. World Health Organization. Lyon, France: International Agency for Research on Cancer, 2008. 474–80.
- 22 Fielding AK, Goldstone AH. Allogeneic haematopoietic stem cell transplant in Philadelphia-positive acute lymphoblastic leukaemia. Bone Marrow Transplant 2008; 41: 447–53.
- 23 Pidala J, Djulbegovic B, Anasetti C, et al. Allogeneic hematopoietic cell transplantation for adult acute lymphoblastic leukemia (ALL) in first complete remission. Cochrane Database Syst Rev 2011: CD008818.
- 24 Popat U, Carrum G, Heslop HE. Haemopoietic stem cell transplantation for acute lymphoblastic leukaemia. Cancer Treat Rev 2003; 29: 3–10.
- 25 Chan KW. Acute lymphoblastic leukemia. Curr Probl Pediatr Adolesc Health Care 2002; 32: 40–9.
- 26 Estey EH. How to manage high-risk acute myeloid leukemia. Leukemia 2011;26:861–9.
- 27 Jabbour E, Cortes JE, Giles FJ, et al. Current and emerging treatment options in chronic myeloid leukemia. Cancer 2007; 109: 2171–81.
- 28 Goldman JM, Melo JV. Chronic myeloid leukemia—advances in biology and new approaches to treatment. N Engl J Med 2003; 349: 1451–64.
- 29 Kantarjian H, O'Brien S, Jabbour E, et al. Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: a single-institution historical experience. Blood 2012; 119: 1981–7.
- 30 Breccia M, Tiribelli M, Alimena G. Tyrosine kinase inhibitors for elderly chronic myeloid leukemia patients: a systematic review of efficacy and safety data. Crit Rev Oncol Hematol 2012. PMID: 22280914.
- 31 Abrisqueta P, Pereira A, Rozman C, et al. Improving survival in patients with chronic lymphocytic leukemia (1980–2008): the Hospital Clinic of Barcelona experience. Blood 2009; 114: 2044–50.
- 32 Brenner H, Gondos A, Pulte D. Trends in long-term survival of patients with chronic lymphocytic leukemia from the 1980s to the early 21st century. Blood 2008; 111: 4916–21.
- 33 van den Broek E, Kater P, van de Schans S, et al. Chronic lymphocytic leukaemia in the Netherlands: trends in incidence, treatment and survival, 1989–2008. Eur J Cancer 2012; 48: 889–95.
- 34 Auer RL, Gribben J, Cotter FE. Emerging therapy for chronic lymphocytic leukaemia. Br J Haematol 2007; 139: 635–44.
- 35 Sant M, Allemani C, Santaquilani M, et al. EUROCARE-4. Survival of cancer patients diagnosed in 1995–1999. Results and commentary. Eur J Cancer 2009; 45: 931–91.
- 36 Chatenoud L, Bertuccio P, Bosetti C, et al. Childhood cancer mortality in America, Asia, and Oceania, 1970 through 2007. Cancer 2010; 116: 5063–74.