Cancer Genetics
XRCC1 gene polymorphisms and esophageal squamous cell carcinoma risk in Chinese population: A meta-analysis of case–control studies
Liping Dai,
Kaijuan Wang,
Jianying Zhang,
Quanjun Lv,
Xiaobing Wu,
Yanping Wang,
Corresponding Author
Liping Dai
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
Proteomics Research Center, Zhengzhou University, Zhengzhou, China
Fax: +86-371-67781964.
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, No. 100 Science Avenue, 450001 Zhengzhou, ChinaSearch for more papers by this authorKaijuan Wang
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
Proteomics Research Center, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorJianying Zhang
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
Proteomics Research Center, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorQuanjun Lv
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorXiaobing Wu
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorYanping Wang
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorLiping Dai,
Kaijuan Wang,
Jianying Zhang,
Quanjun Lv,
Xiaobing Wu,
Yanping Wang,
Corresponding Author
Liping Dai
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
Proteomics Research Center, Zhengzhou University, Zhengzhou, China
Fax: +86-371-67781964.
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, No. 100 Science Avenue, 450001 Zhengzhou, ChinaSearch for more papers by this authorKaijuan Wang
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
Proteomics Research Center, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorJianying Zhang
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
Proteomics Research Center, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorQuanjun Lv
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorXiaobing Wu
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorYanping Wang
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorAbstract
Two non-synonymous polymorphisms Arg194Trp and Arg399Gln in the DNA-base excision repair gene X-ray repair cross-complementing group 1 (XRCC1) have been implicated in risk for esophageal cancer. However, the results from different studies remain controversial. The present meta-analysis of literatures was performed to clarify these associations in Chinese population. A comprehensive literature search was conducted to identify all case–control studies of XRCC1 polymorphisms Arg194Trp and Arg399Gln and risk for esophageal squamous cell carcinoma (ESCC). A total of 9 eligible studies, including 1,538 ESCC cases and 2,472 controls, were identified to the meta-analysis. The odds ratio (OR) for the variant homozygous genotype Trp/Trp of the Arg194Trp polymorphism, compared with the wild-type homozygote Arg/Arg, was 1.59 (p = 0.0007), with 95% confidence interval (95% CI) 1.22–2.09, for ESCC risk without between-study heterogeneity. However, there was no statistically significant associations of ESCC risk in the dominant model Arg/Trp+Trp/Trp (OR 0.97; 95% CI 0.84–1.12; p = 0.69) and heterozygous genotype Arg/Trp (OR 0.90; 95% CI 0.77–1.04; p = 0.16) when comparing with wild-type genotype Arg/Arg. For Arg399Gln, there was no effect in dominant modeling (Arg/Gln+Gln/Gln vs. Arg/Arg: OR 0.92; 95% CI 0.80–1.06; p = 0.25), and the variant Gln/Gln homozygote was not associated with ESCC risk (OR 1.29; 95% CI 0.79–2.10; p = 0.31), either. In conclusion, Arg194Trp genetic polymorphism may be associated with an increased risk for developing ESCC and a study with the larger sample size is needed to further evaluate gene–environment interaction on XRCC1 polymorphisms and ESCC risk. © 2009 UICC
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