Cancer of the mouth and pharynx, occupation and exposure to chemical agents in Finland [in 1971–95]
Corresponding Author
Laura Tarvainen
Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Helsinki, Helsinki, Finland
Fax: +358-9-47188505
Sotilastorpantie 19 as. 1, 02680 Espoo, FinlandSearch for more papers by this authorPentti Kyyrönen
Finnish Cancer Registry, Institute of Statistical and Epidemiological Cancer Research, Helsinki, Finland
Search for more papers by this authorTimo Kauppinen
Finnish Institute of Occupational Health, Helsinki, Finland
Search for more papers by this authorEero Pukkala
Finnish Cancer Registry, Institute of Statistical and Epidemiological Cancer Research, Helsinki, Finland
Search for more papers by this authorCorresponding Author
Laura Tarvainen
Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Helsinki, Helsinki, Finland
Fax: +358-9-47188505
Sotilastorpantie 19 as. 1, 02680 Espoo, FinlandSearch for more papers by this authorPentti Kyyrönen
Finnish Cancer Registry, Institute of Statistical and Epidemiological Cancer Research, Helsinki, Finland
Search for more papers by this authorTimo Kauppinen
Finnish Institute of Occupational Health, Helsinki, Finland
Search for more papers by this authorEero Pukkala
Finnish Cancer Registry, Institute of Statistical and Epidemiological Cancer Research, Helsinki, Finland
Search for more papers by this authorAbstract
The objective of this article was to find associations between cancer of the mouth and pharynx, occupation and chemical exposure. A cohort of Finns born between 1906 and 1945 was followed-up for 46.8 (21.5 in males and 25.3 in females) million person-years during 1971–95. Incident cases of cancer of the mouth and pharynx (n = 2,708) were identified in a record linkage with the Finnish Cancer Registry. The Census occupations in 1970 were converted to chemical exposures with a job-exposure matrix (FINJEM). Cumulative exposure (CE) was calculated as the product of prevalence, level and duration of the exposure. Standardized incidence ratio (SIR) was calculated for each of the 393 occupations, and for CE categories of the 43 chemical agents, using total Finnish population as reference. Relative risks (RR) comparing various CE-categories with unexposed ones were defined for selected agents by Poisson regression analysis. Elevated SIRs were observed among lawyers, authors, journalists, performing artists, musicians, electronics and telefitters, painters (building), building hands, dockers, unskilled labourers and hotel porters in males and private secretaries, dressmakers, shoemakers and cobblers, waiters, pursers and stewardesses in females. The multivariate analyses showed high RRs for high exposure to aliphatic and alicyclic hydrocarbons, pesticides and alcohol. In conclusion, occupations with high SIRs were mostly the ones with high consumption of alcohol. Exposure to solvents and possibly to pesticides, engine exhaust, textile dust and leather dust may increase the risk of cancer of mouth and pharynx. © 2008 Wiley-Liss, Inc.
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