Food groups and risk of hepatocellular carcinoma: A multicenter case-control study in Italy
Corresponding Author
Renato Talamini
Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy
Fax: +39-0434-659222.
Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Via Pedemontana Occ. 12, 33081 Aviano (PN), ItalySearch for more papers by this authorJerry Polesel
Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy
Search for more papers by this authorMaurizio Montella
Servizio di Epidemiologia, Istituto Tumori “Fondazione Pascale”, Cappella dei Cangiani, Naples, Italy
Search for more papers by this authorLuigino Dal Maso
Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy
Search for more papers by this authorAnna Crispo
Servizio di Epidemiologia, Istituto Tumori “Fondazione Pascale”, Cappella dei Cangiani, Naples, Italy
Search for more papers by this authorLuigi G. Tommasi
Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy
Search for more papers by this authorFrancesco Izzo
Divisione di Chirurgia D, Istituto Tumori “Fondazione Pascale”, Cappella dei Cangiani, Naples, Italy
Search for more papers by this authorMarina Crovatto
Divisione di Microbiologia e Immunologia, Ospedale “S. Maria degli Angeli”, Pordenone, Italy
Search for more papers by this authorCarlo La Vecchia
Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy
Search for more papers by this authorSilvia Franceschi
International Agency for Research on Cancer, Lyon, France
Search for more papers by this authorCorresponding Author
Renato Talamini
Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy
Fax: +39-0434-659222.
Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Via Pedemontana Occ. 12, 33081 Aviano (PN), ItalySearch for more papers by this authorJerry Polesel
Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy
Search for more papers by this authorMaurizio Montella
Servizio di Epidemiologia, Istituto Tumori “Fondazione Pascale”, Cappella dei Cangiani, Naples, Italy
Search for more papers by this authorLuigino Dal Maso
Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy
Search for more papers by this authorAnna Crispo
Servizio di Epidemiologia, Istituto Tumori “Fondazione Pascale”, Cappella dei Cangiani, Naples, Italy
Search for more papers by this authorLuigi G. Tommasi
Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy
Search for more papers by this authorFrancesco Izzo
Divisione di Chirurgia D, Istituto Tumori “Fondazione Pascale”, Cappella dei Cangiani, Naples, Italy
Search for more papers by this authorMarina Crovatto
Divisione di Microbiologia e Immunologia, Ospedale “S. Maria degli Angeli”, Pordenone, Italy
Search for more papers by this authorCarlo La Vecchia
Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy
Search for more papers by this authorSilvia Franceschi
International Agency for Research on Cancer, Lyon, France
Search for more papers by this authorAbstract
The role of diet, except for alcohol drinking and aflatoxin contamination, in the etiology of hepatocellular carcinoma (HCC) is unclear. A hospital-based case-control study was conducted in Italy in 1999–2002, including 185 incident, histologically-confirmed cases of HCC. Controls were 412 subjects admitted to hospitals for acute, nonneoplastic diseases unrelated to diet. Dietary habits were assessed using a validated food-frequency questionnaire. Odds ratios (ORs) and the corresponding 95% confidence intervals (CI) were computed using unconditional multiple logistic regression, adjusting for hepatitis B (HBV) and hepatitis C (HCV) virus infection and alcohol drinking. Energy adjustment was carried out by means of the residual model. A significant inverse relation was found between intakes of milk and yoghurt (OR = 0.28; 95% CI: 0.13–0.61), white meats (OR = 0.44; 95% CI: 0.20–0.95), eggs (OR = 0.31; 95% CI: 0.14–0.69), and fruits (OR = 0.48; 95% CI: 0.22–1.05) and HCC risk. The favourable effect of high intakes of milk and yoghurt, white meats, eggs and fruits was consistent across strata of HBV and HCV infections. The present study supports the hypothesis of a role of diet in HCC aetiology. Dietary modifications may be indicated in subjects at high-risk for HCC. © 2006 Wiley-Liss, Inc.
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