Relation of childhood brain tumors to exposure of parents and children to tobacco smoke: The Search international case-control study
Corresponding Author
Graziella Filippini
Neuroepidemiology Research Unit, Istituto Nazionale Neurologico “C Besta”, Milan, Italy
Fax: +39-02-70638217
Istituto Nazionale Neurologico “C. Besta”, via Celoria 11, I-20133 Milan, ItalySearch for more papers by this authorPatrick Maisonneuve
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Search for more papers by this authorMargaret McCredie
Cancer Epidemiology Research Unit, New South Wales Cancer Council, Sydney, Australia, and Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
Search for more papers by this authorRaphael Peris-Bonet
Unidad de Información y Documentacion Medicosanitaria, IEDHC (CSIC-Universitat de Valencia), Valencia, Spain
Search for more papers by this authorBaruch Modan
Department of Clinical Epidemiology, Chaim Sheba Medical Center, Sackler School of Medicine, Tel-Hashomer, Israel
Drs. Choi and Modan are deceased.
Search for more papers by this authorSusan Preston-Martin
Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles, CA, USA
Search for more papers by this authorBeth A. Mueller
Fred Hutchison Cancer Research Center, Seattle, WA, USA
Search for more papers by this authorElizabeth A. Holly
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
Search for more papers by this authorSylvaine Cordier
INSERM U435, Université de Rennes I, Rennes Cedex, France
Search for more papers by this authorN.W. Choi
Manitoba Cancer Treatment and Research Foundation, Winnipeg, Canada
Drs. Choi and Modan are deceased.
Search for more papers by this authorJulian Little
Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, Scotland
Search for more papers by this authorAnnie Arslan
International Agency for Research on Cancer, Lyon, France
Search for more papers by this authorPeter Boyle
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Search for more papers by this authorCorresponding Author
Graziella Filippini
Neuroepidemiology Research Unit, Istituto Nazionale Neurologico “C Besta”, Milan, Italy
Fax: +39-02-70638217
Istituto Nazionale Neurologico “C. Besta”, via Celoria 11, I-20133 Milan, ItalySearch for more papers by this authorPatrick Maisonneuve
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Search for more papers by this authorMargaret McCredie
Cancer Epidemiology Research Unit, New South Wales Cancer Council, Sydney, Australia, and Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
Search for more papers by this authorRaphael Peris-Bonet
Unidad de Información y Documentacion Medicosanitaria, IEDHC (CSIC-Universitat de Valencia), Valencia, Spain
Search for more papers by this authorBaruch Modan
Department of Clinical Epidemiology, Chaim Sheba Medical Center, Sackler School of Medicine, Tel-Hashomer, Israel
Drs. Choi and Modan are deceased.
Search for more papers by this authorSusan Preston-Martin
Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles, CA, USA
Search for more papers by this authorBeth A. Mueller
Fred Hutchison Cancer Research Center, Seattle, WA, USA
Search for more papers by this authorElizabeth A. Holly
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
Search for more papers by this authorSylvaine Cordier
INSERM U435, Université de Rennes I, Rennes Cedex, France
Search for more papers by this authorN.W. Choi
Manitoba Cancer Treatment and Research Foundation, Winnipeg, Canada
Drs. Choi and Modan are deceased.
Search for more papers by this authorJulian Little
Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, Scotland
Search for more papers by this authorAnnie Arslan
International Agency for Research on Cancer, Lyon, France
Search for more papers by this authorPeter Boyle
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Search for more papers by this authorAbstract
The etiology of childhood brain tumors (CBTs) remains unknown. Tobacco smoke contains several known carcinogens and can induce DNA adducts in human placenta and hemoglobin adducts in fetuses. We present the results of an international case-control study to evaluate the association between CBTs and exposure of parents and children to cigarette smoke. The study was undertaken as part of the SEARCH program of the IARC. Nine centers in 7 countries were involved. The studies mainly covered the 1980s and early 1990s. Cases (1,218, ages 0–19 years) were children newly diagnosed with a primary brain tumor; there were 2,223 population-based controls. Most mothers who agreed to participate were interviewed in person at home. Odds ratios (ORs) were calculated by unconditional logistic regression, adjusted for age, sex and center, for all types of CBT combined, 4 CBT histotypes, 5 age groups and each center. There was no association between the risk of brain tumors in the child and parental smoking prior to pregnancy, maternal smoking or regular exposure to others' cigarette smoke during pregnancy at home or at work, or passive smoking by the child during the first year of life. These results did not change considering the child's age at diagnosis, the histologic type of tumor or center. © 2002 Wiley-Liss, Inc.
REFERENCES
- 1 Parkin DM, Whelan SL, Ferlay J, Raymond L, Young J, eds. Cancer incidence in Five Continents. vol. VII, no. 143. Lyon: IARC, 1997.
- 2 Rice JM, Ward JM. Age dependence of susceptibility to carcinogenesis in the nervous system. Ann NY Acad Sci 1982; 38: 274–89.
- 3 Rice JM, Wilbourn JD. Tumors of the nervous system in carcinogenic hazard identification. Toxicol Pathol 2000; 28: 202–14.
- 4 Ivankovic S. Teratogenic and carcinogenic effects of some chemicals during prenatal life in rats, Syrian golden hamsters, and guinea pigs. Natl Cancer Inst Monogr 1979; 51: 103–15.
- 5 Swenberg JA, Koestner A, Wechsler W, Denlinger RH. Quantitative aspects of transplacental tumor induction with ethylnitrosourea in rats. Cancer Res 1972; 32: 2656–60.
- 6 Hecht SS, Hoffmann D. N-nitroso compounds and tobacco-induced cancer in man. In: O'Neill IK, Chen J, Bartsch H, eds. Relevance to human cancer of N-nitroso compounds, tobacco smoke and mycotoxins. no. 105, Lyon: IARC, 1991. 54–61.
- 7 Perera FP, Jedrychowski W, Rauh V, Whyatt RM. Molecular epidemiologic research on the effects of environmental pollutants on the fetus. Environ Health Perspect 1999; 107 (Suppl 3): 451–60.
- 8 Lackmann GM, Salzberger U, Tollner U, Chen M, Carmella SG, Hecht SS. Metabolites of a tobacco-specific carcinogen in urine from newborns. J Natl Cancer Inst 1999; 91: 459–65.
- 9 Arnould JP, Verhoest P, Bach V, Libert JP, Belegaud J. Detection of benzo[a]pyrene-DNA adducts in human placenta and umbilical cord blood. Hum Exp Toxicol 1997; 16: 716–21.
- 10 Everson RB, Randerath E, Santella RM, Cefalo RC, Avitts TA, Randerath K. Detection of smoking-related covalent DNA adducts in human placenta. Science 1986; 231: 54–7.
- 11 Coghlin J, Gann PH, Hammond SK, Skipper PL, Taghizadeh K, Paul M, Tannenbaum SR. 4-aminobiphenyl hemoglobin adducts in fetuses exposed to tobacco smoke carcinogen in utero. J Natl Cancer Inst 1991; 83: 274–80.
- 12 International Agency for Research on Cancer, World Health Organization. Tobacco smoking. Monographs on the evaluation of the carcinogenic risk of chemicals to humans. vol. 38. Geneva: IARC, 1986.
- 13 Finette BA, O'Neil JP, Vacek PM, Albertini RJ. Gene mutations with characteristic deletions in cord blood T lymphocytes associated with passive maternal exposure to tobacco smoke. Nat Med 1998; 4: 1144–51.
- 14 Preston-Martin S, Yu MC, Benton B, Henderson BE. N-Nitroso compounds and childhood brain tumors: a case-control study. Cancer Res 1982; 42: 5240–5.
- 15 John EM, Savitz DA, Sandler DP. Prenatal exposure to parents' smoking and childhood cancer. Am J Epidemiol 1991; 133: 123–32.
- 16 Ji BT, Shu XO, Linet MS, Zheng W, Wacholder S, Gao YT, Ying DM, Jin F. Paternal cigarette smoking and the risk of childhood cancer among offspring of nonsmoking mothers. J Natl Cancer Inst 1997; 89: 238–44.
- 17 Sorahan T, Prior P, Lancashire RJ, Faux SP, Hulten MA, Peck IM, Stewart AM. Childhood cancer and parental use of tobacco: deaths from 1971 to 1976. Br J Cancer 1997; 76: 1525–31.
- 18 Howe GR, Burch JD, Chiarelli AM, Risch HA, Choi BCK. An exploratory case-control study of brain tumors in children. Cancer Res 1989; 49: 4349–52.
- 19 Birch JM, Hartley AL, Teare MD, Blair V, McKinney PA, Mann JR, Stiller CA, Draper GJ, Johnston HE, Cartwright RA, Waterhouse JAH. The inter-regional epidemiological study of childhood cancer (IRESCC): case-control study of children with central nervous system tumors. Br J Neurosurg 1990; 4: 17–26.
- 20 Kuijten RR, Bunin GR, Nass CC, Meadows AT. Gestational and familial risk factors for childhood astrocytoma: results of a case-control study. Cancer Res 1990; 50: 2608–12.
- 21 Gold EB, Leviton A, Lopez R, Gilles FH, Hedley-Whyte ET, Kolonel LN, Lyon JL, Swanson GM, Weiss NS, West D, Aschenbrener C, Austin DF. Parental smoking and risk of childhood brain tumors. Am J Epidemiol 1993; 137: 620–8.
- 22 Bunin GR, Buckley JD, Boesel CP, Rorke LB, Meadows AT. Risk factors for astrocytic glioma and primitive neuroectodermal tumor of the brain in young children: a report from the Children's Cancer Group. Cancer Epidemiol Biomarkers Prev 1994; 3: 197–204.
- 23 Little J. Epidemiology of childhood cancer. no. 149. Lyon: IARC, 1999.
- 24 Sasco AJ, Vainio H. From in utero and childhood exposure to parental smoking to childhood cancer: a possible link and the need for action. Hum Exp Toxicol 1999; 18: 192–201.
- 25 Filippini G, Farinotti M, Lovicu G, Maisonneuve P, Boyle P. Mother's active and passive smoking during pregnancy and risk of brain tumors in children. Int J Cancer 1994; 57: 769–74.
- 26 Cordier S, Iglesias MJ, LeGoaster C, Guyot MM, Mandereau L, Hemon D. Incidence and risk factors for childhood brain tumors in the Ile de France. Int J Cancer 1994; 59: 776–82.
- 27 McCredie M, Maisonneuve P, Boyle P. Antenatal risk factors for malignant brain tumors in New South Wales children. Int J Cancer 1994; 56: 6–10.
- 28 McCredie M, Maisonneuve P, Boyle P. Perinatal and early postnatal risk factors for malignant brain tumours in New South Wales children. Int J Cancer 1994; 56: 11–5.
- 29 Norman MA, Holly EA, Ahn DK, Preston-Martin S, Mueller BA, Bracci PM. Prenatal exposure to tobacco smoke and childhood brain tumors: results from the United States West Coast childhood brain tumor study. Cancer Epidemiol Biomarkers Prev 1996; 5: 127–33.
- 30SAS system version 6.12. Cary, NC: SAS Institute Inc., 1998.
- 31 Norman MA, Holly EA, Preston-Martin S. Childhood brain tumors and exposure to tobacco smoke. Cancer Epidemiol Biomarkers Prev 1996; 5: 85–91.
- 32 Boffetta P, Tredaniel J, Greco A. Risk of childhood cancer and adult lung cancer after childhood exposure to passive smoke: a meta-analysis. Environ Health Perspect 2000; 108: 73–82.
- 33 Klebanoff MA, Clemens JD, Read JS. Maternal smoking during pregnancy and childhood cancer. Am J Epidemiol 1996; 144: 1028–33.
- 34 Linet MS, Gridley G, Cnattingius S, Nicholson HS, Martinsson U, Glimelius B, Adami HO, Zack M. Maternal and perinatal risk factors for childhood brain tumors. Cancer Causes Control 1996; 7: 437–48.
- 35 Gibbons LE, Ponsonby A-L, Dwyer T. A comparison of prospective and retrospective responses on sudden infant death syndrome by case and control mothers. Am J Epidemiol 1993; 137: 654–9.
- 36 Verkerk PH, Buitendijk SE, Verloove-Vanhorick SP. Differential misclassification of alcohol and cigarette consumption by pregnancy outcome. Int J Epidemiol 1994; 23: 1218–25.
- 37 Wong M, Koren G. Bias in maternal reports of smoking during pregnancy associated with fetal distress. Can J Public Health 2001; 92: 109–12.
- 38 Mackenzie SG, Lippman A. An investigation of report bias in a case-control study of pregnancy outcome. Am J Epidemiol 1989; 129: 65–75.
- 39 Infante-Rivard C, Jacques L. Empirical study of parental recall bias. Am J Epidemiol 2000; 152: 480–6.
- 40 Stjernfeldt M, Berglund K, Lindsten J, Ludvigsson J. Maternal smoking during pregnancy and risk of childhood cancer. Lancet 1986; I: 1350–2.
- 41 Brooke OG, Anderson HR, Bland JM, Peacock JL, Stewart CM. Effects on birth weight of smoking, alcohol, caffeine, socioeconomic factors, and psychosocial stress. Br Med J 1989; 298: 795–801.
- 42 Passaro KT, Noss J, Savitz DA, Little RE. Agreement between self and partner reports of paternal drinking and smoking. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Int J Epidemiol 1997; 26: 315–20.
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