Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease†
Sea Bong Hyun MD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
HSB and MN (Makoto Naganuma) contributed equally to this study.
Search for more papers by this authorYoshio Kitazume MD, PhD
Department of Radiology, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorMasakazu Nagahori MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
HSB and MN (Makoto Naganuma) contributed equally to this study.
Search for more papers by this authorAkira Toriihara MD
Department of Radiology, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorToshimitsu Fujii MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorKiichiro Tsuchiya MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorShinji Suzuki MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorEriko Okada MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorAkihiro Araki MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorMakoto Naganuma MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Mamoru Watanabe MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Division of Gastroenterology and Hepatology, Internal Medicine, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, JapanSearch for more papers by this authorSea Bong Hyun MD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
HSB and MN (Makoto Naganuma) contributed equally to this study.
Search for more papers by this authorYoshio Kitazume MD, PhD
Department of Radiology, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorMasakazu Nagahori MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
HSB and MN (Makoto Naganuma) contributed equally to this study.
Search for more papers by this authorAkira Toriihara MD
Department of Radiology, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorToshimitsu Fujii MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorKiichiro Tsuchiya MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorShinji Suzuki MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorEriko Okada MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorAkihiro Araki MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorMakoto Naganuma MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Mamoru Watanabe MD, PhD
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Division of Gastroenterology and Hepatology, Internal Medicine, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, JapanSearch for more papers by this authorSupported in part by Health and Labour Sciences Research Grants for research on intractable diseases from Ministry of Health, Labour and Welfare of Japan.
Abstract
Background:
We developed novel magnetic resonance enterocolonography (MREC) for simultaneously evaluating both small and large bowel lesions in patients with Crohn's disease (CD). The aim of this study was to evaluate the diagnostic performance of MREC by comparing results of this procedure to those of endoscopies for evaluating the small and large bowel lesions of patients with CD.
Methods:
Thirty patients with established CD were prospectively examined by newly developed MREC. Patients underwent ileocolonoscopy (ICS) (24 procedures) or double-balloon endoscopy (DBE) (10 procedures) after MREC on the same day. Two gastroenterologists and two radiologists who were blinded to the results of another study evaluated endoscopy and MREC findings, respectively.
Results:
In colonic lesions the sensitivities of the MREC for deep mucosal lesions (DML), all CD lesions, and stenosis were 88.2, 61.8, and 71.4%, respectively, while the specificities were 98.1, 95.3, and 97.7%, respectively. In small intestinal lesions, MREC sensitivities for DML, all CD lesions, and stenosis were 100, 85.7, and 100%, respectively, while specificities were 100, 90.5, and 93.1%, respectively. Endoscopic scores were significantly correlated with MREC scores. Eleven (46%) of the 24 patients who were clinically not suspected to show stricture were observed to demonstrate stricture by radiologists.
Conclusions:
Our results demonstrated that MREC can simultaneously detect the CD lesions of the small and large intestine. MREC can be performed without radiation exposure, the use of enema, or the placement of a naso-jejunal catheter. MREC and endoscopy have comparable abilities for evaluating mucosal lesions of patients with CD. (Inflamm Bowel Dis 2010;)
Supporting Information
Additional supporting information may be found in the online version of this article.
| Filename | Description |
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| IBD_21478_sm_suppTable1.tif121.2 KB | Supporting Table 1 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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