Basic Science Review
Using metabolomic analysis to understand inflammatory bowel diseases
Hui-Ming Lin PhD,
Nuala A. Helsby PhD,
Daryl D. Rowan PhD,
Lynnette R. Ferguson PhD,
Hui-Ming Lin PhD
School of Medical Sciences, University of Auckland, Auckland, New Zealand
New Zealand Institute for Plant & Food Research Limited, New Zealand
Nutrigenomics New Zealand
Search for more papers by this authorNuala A. Helsby PhD
School of Medical Sciences, University of Auckland, Auckland, New Zealand
Search for more papers by this authorDaryl D. Rowan PhD
New Zealand Institute for Plant & Food Research Limited, New Zealand
Nutrigenomics New Zealand
Search for more papers by this authorCorresponding Author
Lynnette R. Ferguson PhD
School of Medical Sciences, University of Auckland, Auckland, New Zealand
Nutrigenomics New Zealand
School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New ZealandSearch for more papers by this authorHui-Ming Lin PhD,
Nuala A. Helsby PhD,
Daryl D. Rowan PhD,
Lynnette R. Ferguson PhD,
Hui-Ming Lin PhD
School of Medical Sciences, University of Auckland, Auckland, New Zealand
New Zealand Institute for Plant & Food Research Limited, New Zealand
Nutrigenomics New Zealand
Search for more papers by this authorNuala A. Helsby PhD
School of Medical Sciences, University of Auckland, Auckland, New Zealand
Search for more papers by this authorDaryl D. Rowan PhD
New Zealand Institute for Plant & Food Research Limited, New Zealand
Nutrigenomics New Zealand
Search for more papers by this authorCorresponding Author
Lynnette R. Ferguson PhD
School of Medical Sciences, University of Auckland, Auckland, New Zealand
Nutrigenomics New Zealand
School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New ZealandSearch for more papers by this authorAbstract
Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) attributed to a dysregulated immune response towards intestinal microbiota. Although various susceptibility genes have been identified for CD and UC, the exact disease etiology is unclear and complicated by the influence of environmental factors. Metabolomic analysis enables high sample throughput measurements of multiple metabolites in biological samples. The use of metabolomic analysis in medical sciences has revealed metabolite perturbations associated with diseases. This article provides a summary of the current understanding of IBD, and describes potential applications and previous metabolomic analysis in IBD research to understand IBD pathogenesis and improve IBD therapy. Inflamm Bowel Dis 2011
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