Synthesis of Natural Atisane-Type Diterpenoids by retro-Biomimetic Transformations
Corresponding Author
Nicon Ungur
Institutul de Chimie al Academiei de Ştiinţe a Moldovei, str. Academiei, 3, MD 2028, Chişinău, Republic of Moldova(phone:+373-22-739769, fax: +373-22-739775)
Institutul de Chimie al Academiei de Ştiinţe a Moldovei, str. Academiei, 3, MD 2028, Chişinău, Republic of Moldova(phone:+373-22-739769, fax: +373-22-739775)Search for more papers by this authorVeaceslav Kulciţki
Institutul de Chimie al Academiei de Ştiinţe a Moldovei, str. Academiei, 3, MD 2028, Chişinău, Republic of Moldova(phone:+373-22-739769, fax: +373-22-739775)
Search for more papers by this authorOlga Chetraru
Institutul de Chimie al Academiei de Ştiinţe a Moldovei, str. Academiei, 3, MD 2028, Chişinău, Republic of Moldova(phone:+373-22-739769, fax: +373-22-739775)
Search for more papers by this authorMarina Grinco
Institutul de Chimie al Academiei de Ştiinţe a Moldovei, str. Academiei, 3, MD 2028, Chişinău, Republic of Moldova(phone:+373-22-739769, fax: +373-22-739775)
Search for more papers by this authorPavel F. Vlad
Institutul de Chimie al Academiei de Ştiinţe a Moldovei, str. Academiei, 3, MD 2028, Chişinău, Republic of Moldova(phone:+373-22-739769, fax: +373-22-739775)
Search for more papers by this authorCorresponding Author
Nicon Ungur
Institutul de Chimie al Academiei de Ştiinţe a Moldovei, str. Academiei, 3, MD 2028, Chişinău, Republic of Moldova(phone:+373-22-739769, fax: +373-22-739775)
Institutul de Chimie al Academiei de Ştiinţe a Moldovei, str. Academiei, 3, MD 2028, Chişinău, Republic of Moldova(phone:+373-22-739769, fax: +373-22-739775)Search for more papers by this authorVeaceslav Kulciţki
Institutul de Chimie al Academiei de Ştiinţe a Moldovei, str. Academiei, 3, MD 2028, Chişinău, Republic of Moldova(phone:+373-22-739769, fax: +373-22-739775)
Search for more papers by this authorOlga Chetraru
Institutul de Chimie al Academiei de Ştiinţe a Moldovei, str. Academiei, 3, MD 2028, Chişinău, Republic of Moldova(phone:+373-22-739769, fax: +373-22-739775)
Search for more papers by this authorMarina Grinco
Institutul de Chimie al Academiei de Ştiinţe a Moldovei, str. Academiei, 3, MD 2028, Chişinău, Republic of Moldova(phone:+373-22-739769, fax: +373-22-739775)
Search for more papers by this authorPavel F. Vlad
Institutul de Chimie al Academiei de Ştiinţe a Moldovei, str. Academiei, 3, MD 2028, Chişinău, Republic of Moldova(phone:+373-22-739769, fax: +373-22-739775)
Search for more papers by this authorAbstract
An efficient one step, retro-biomimetic procedure for the synthesis of natural products having the atisane structure is described (Scheme 2), natural products which are components of medicinal plants and possess relevant biological activity. Their structures were confirmed by chemical transformations and spectral data. The starting materials were the known ent-kaur-16-en-19-oic acid (1) and ent-trachyloban-19-oic acid (2), diterpenoids readily available from the waste of sunflower.
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