Cytotoxic Naphtho-γ-pyrones from the Mangrove Endophytic Fungus Aspergillus tubingensis (GX1-5E)
Hong-Bo Huang
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P. R. China
These authors contributed equally to this work.
Search for more papers by this authorZe-En Xiao
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
These authors contributed equally to this work.
Search for more papers by this authorXiao-Jun Feng
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
Search for more papers by this authorCai-Huan Huang
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
Search for more papers by this authorXun Zhu
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, P. R. China
Search for more papers by this authorJian-Hua Ju
CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P. R. China
Search for more papers by this authorMeng-Feng Li
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, P. R. China
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, P. R. China
Search for more papers by this authorYong-Cheng Lin
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, P. R. China
Search for more papers by this authorCorresponding Author
Lan Liu
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, P. R. China
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, P. R. ChinaSearch for more papers by this authorCorresponding Author
Zhi-Gang She
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, P. R. China
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, P. R. ChinaSearch for more papers by this authorHong-Bo Huang
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P. R. China
These authors contributed equally to this work.
Search for more papers by this authorZe-En Xiao
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
These authors contributed equally to this work.
Search for more papers by this authorXiao-Jun Feng
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
Search for more papers by this authorCai-Huan Huang
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
Search for more papers by this authorXun Zhu
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, P. R. China
Search for more papers by this authorJian-Hua Ju
CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P. R. China
Search for more papers by this authorMeng-Feng Li
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, P. R. China
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, P. R. China
Search for more papers by this authorYong-Cheng Lin
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, P. R. China
Search for more papers by this authorCorresponding Author
Lan Liu
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, P. R. China
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, P. R. ChinaSearch for more papers by this authorCorresponding Author
Zhi-Gang She
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China (phone/fax: +86-20-8411-4834 ( L. L. ), +86-20-8403-4096 ( Z.-G. S. )
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, P. R. China
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, P. R. ChinaSearch for more papers by this authorAbstract
Four new dimeric naphtho-γ-pyrones, named rubasperone D (1), rubasperone E (2), rubasperone F (3), and its atropisomer rubasperone G (4), together with four known monomeric naphtho-γ-pyrones, TMC 256 A1 (5), rubrofusarin B (6), fonsecin (7), and flavasperone (8), were isolated from the mangrove endophytic fungus Aspergillus tubingensis (GX1-5E) cultivated in solid rice medium. Their structures were elucidated by spectroscopic methods, including IR, 1D- and 2D-NMR, and MS. In the in vitro cytotoxicity assays, 5 displayed inhibitory activities against tumor cell lines of MCF-7, MDA-MB-435, Hep3B, Huh7, SNB19, and U87 MG with IC50 values between 19.92 and 47.98 μM. Compounds 1, 6, and 8 also showed mild cytotoxic activity.
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