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[5-Leucin]enkephalin-Related Glycoconjugates: Structurally Novel Agents Effective against HIV-1

Corresponding Author

Štefica Horvat

Department of Organic Chemistry and Biochemistry, ‘Ruder Bošcarković’ Institute, P.O.B. 1016, 41001 Zagreb, Yugoslavia

Department of Organic Chemistry and Biochemistry, ‘Ruder Bošcarković’ Institute, P.O.B. 1016, 41001 Zagreb, YugoslaviaSearch for more papers by this author

Lidija Varga,

Lidija Varga

Department of Organic Chemistry and Biochemistry, ‘Ruder Bošcarković’ Institute, P.O.B. 1016, 41001 Zagreb, Yugoslavia

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Jaroslav Horvat,

Jaroslav Horvat

Department of Organic Chemistry and Biochemistry, ‘Ruder Bošcarković’ Institute, P.O.B. 1016, 41001 Zagreb, Yugoslavia

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Andreas Pfützner,

Andreas Pfützner

Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Paul-Erlich-Str. 42–44, D–6000 Frankfurt 70

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Haryadi Suhartono,

Haryadi Suhartono

Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Paul-Erlich-Str. 42–44, D–6000 Frankfurt 70

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Helga Rübsamen-Waigmann,

Helga Rübsamen-Waigmann

Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Paul-Erlich-Str. 42–44, D–6000 Frankfurt 70

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Štefica Horvat,

Corresponding Author

Štefica Horvat

Department of Organic Chemistry and Biochemistry, ‘Ruder Bošcarković’ Institute, P.O.B. 1016, 41001 Zagreb, Yugoslavia

Department of Organic Chemistry and Biochemistry, ‘Ruder Bošcarković’ Institute, P.O.B. 1016, 41001 Zagreb, YugoslaviaSearch for more papers by this author

Lidija Varga,

Lidija Varga

Department of Organic Chemistry and Biochemistry, ‘Ruder Bošcarković’ Institute, P.O.B. 1016, 41001 Zagreb, Yugoslavia

Search for more papers by this author

Jaroslav Horvat,

Jaroslav Horvat

Department of Organic Chemistry and Biochemistry, ‘Ruder Bošcarković’ Institute, P.O.B. 1016, 41001 Zagreb, Yugoslavia

Search for more papers by this author

Andreas Pfützner,

Andreas Pfützner

Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Paul-Erlich-Str. 42–44, D–6000 Frankfurt 70

Search for more papers by this author

Haryadi Suhartono,

Haryadi Suhartono

Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Paul-Erlich-Str. 42–44, D–6000 Frankfurt 70

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Helga Rübsamen-Waigmann,

Helga Rübsamen-Waigmann

Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Paul-Erlich-Str. 42–44, D–6000 Frankfurt 70

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First published: 7 August 1991

https://doi.org/10.1002/hlca.19910740505

Citations: 9

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Abstract

A series of [Leu⁵]enkephalin-related glycoconjugates with an ester-, ether-, or amide-type linkage were synthesized and evaluated for antiviral activity against HIV-1 in a cell-culture system using peripheral blood lymphocytes. All tested glycoconjugates exhibited a certain antiviral activity which was significantly higher than the activity of the parent peptide compound itself. These results indicate that synthetic glycoconjugates of opioid peptides are good candidates for the development of anti-HIV agents.

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Citing Literature

Volume74, Issue5

7 August 1991

Pages 951-955

[5-Leucin]enkephalin-Related Glycoconjugates: Structurally Novel Agents Effective against HIV-1

Abstract

References

Citing Literature

References

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