Correspondence
Letter to the Editor: The Differences Between the Reverse Transcriptional Efficiency of HBV Pregenomic RNA and Transcriptional Efficiency of HBV Covalently Closed Circular DNA
Hao Liao Ph.D.,
Hao Liao Ph.D.
Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen Peking University–The Hong Kong University of Science and Technology Medical Center, Shenzhen, China
Search for more papers by this author Yan Liu Ph.D.,
Yan Liu Ph.D.
Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
Search for more papers by this author Jun Wang Ph.D.,
Jun Wang Ph.D.
Peking University Ditan Teaching Hospital, Beijing, China
Search for more papers by this author Guanxun Cheng Ph.D.,
Guanxun Cheng Ph.D.
Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen Peking University–The Hong Kong University of Science and Technology Medical Center, Shenzhen, China
Search for more papers by this author Dongping Xu Ph.D.,
Dongping Xu Ph.D.
Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
Search for more papers by this author Junhui Chen Ph.D.,
Junhui Chen Ph.D.
Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen Peking University–The Hong Kong University of Science and Technology Medical Center, Shenzhen, China
Search for more papers by this author Fengmin Lu Ph.D.,
Fengmin Lu Ph.D.
Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
Center for Precision Medicine, Academy of Medical Sciences, Zhengzhou University, Henan, China
Search for more papers by this author
Hao Liao Ph.D.,
Hao Liao Ph.D.
Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen Peking University–The Hong Kong University of Science and Technology Medical Center, Shenzhen, China
Search for more papers by this author Yan Liu Ph.D.,
Yan Liu Ph.D.
Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
Search for more papers by this author Jun Wang Ph.D.,
Jun Wang Ph.D.
Peking University Ditan Teaching Hospital, Beijing, China
Search for more papers by this author Guanxun Cheng Ph.D.,
Guanxun Cheng Ph.D.
Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen Peking University–The Hong Kong University of Science and Technology Medical Center, Shenzhen, China
Search for more papers by this author Dongping Xu Ph.D.,
Dongping Xu Ph.D.
Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
Search for more papers by this author Junhui Chen Ph.D.,
Junhui Chen Ph.D.
Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen Peking University–The Hong Kong University of Science and Technology Medical Center, Shenzhen, China
Search for more papers by this author Fengmin Lu Ph.D.,
Fengmin Lu Ph.D.
Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
Center for Precision Medicine, Academy of Medical Sciences, Zhengzhou University, Henan, China
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First published: 04 March 2021
No abstract is available for this article.
References
- 1Mak LY, Cloherty G, Wong DK, Gersch J, Seto WK, Fung J, et al. HBV RNA profiles in chronic hepatitis B patients under different disease phases and anti-viral therapy. Hepatology 2020 Nov 6. https://doi.org/10.1002/hep.31616. [Epub ahead of print]
- 2Wang J, Shen T, Huang X, Kumar GR, Chen X, Zeng Z, et al. Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound. J Hepatol 2016; 65: 700-710.
- 3Huang H, Wang J, Li W, Chen R, Chen X, Zhang F, et al. Serum HBV DNA plus RNA shows superiority in reflecting the activity of intrahepatic cccDNA in treatment-naive HBV-infected individuals. J Clin Virol 2018; 99-100: 71-78.
- 4Suslov A, Meier MA, Ketterer S, Wang X, Wieland S, Heim MH. Transition to HBeAg-negative chronic hepatitis B virus infection is associated with reduced cccDNA transcriptional activity. J Hepatol 2020 Nov 11. https://doi.org/10.1016/j.jhep.2020.11.003. [Epub ahead of print]
