Localization of epidermal growth factor receptor in hepatocyte nuclei
Ulrich Marti
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Search for more papers by this authorCorresponding Author
Dr. Susan Jo Burwen
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Cell Biology Section 151E, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121===Search for more papers by this authorAlan Wells
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Search for more papers by this authorMary E. Barker
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Search for more papers by this authorSandra Huling
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Search for more papers by this authorAnna M. Feren
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Search for more papers by this authorAlbert L. Jones
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Search for more papers by this authorUlrich Marti
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Search for more papers by this authorCorresponding Author
Dr. Susan Jo Burwen
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Cell Biology Section 151E, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121===Search for more papers by this authorAlan Wells
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Search for more papers by this authorMary E. Barker
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Search for more papers by this authorSandra Huling
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Search for more papers by this authorAnna M. Feren
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Search for more papers by this authorAlbert L. Jones
Cell Biology and Aging Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121; and the Departments of Medicine and Anatomy, the Liver Center and Hooper Foundation, University of California, San Francisco, California 94143
Search for more papers by this authorAbstract
Experiments undertaken to investigate the binding of epidermal growth factor by hepatocyte nuclei showed that: (a) isolated nuclei from both normal and regenerating rat liver are capable of binding 125I-epidermal growth factor, (b) the nuclear epidermal growth factor-binding protein is similar in molecular weight to the plasma membrane epidermal growth factor receptor, (c) monoclonal antibodies produced against the plasma membrane epidermal growth factor receptor recognize the nuclear epidermal growth factor receptor and (d) the nuclear receptor has an affinity for epidermal growth factor comparable to that of the plasma membrane receptor, but fewer (∼ 10%) nuclear receptors are available per protein unit compared with the plasma membrane. (HEPATOLOGY 1991;13:15–20).
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