Immunization of woodchucks with recombinant hepatitis delta antigen does not protect against hepatitis delta virus infection
Corresponding Author
Dr. Peter Karayiannis
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Department of Medicine, St. Mary's Hospital Medical School, South Wharf Road, London W2 1NY, United Kingdom===Search for more papers by this authorJohn Saldanha
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorJohn Monjardino
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorRobert Goldin
Liver Unit, Department of Pathology, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorJanice Main
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorShashi Luther
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorMark Easton
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorAntonio Ponzetto
Division of Gastroenterology, Ospedale Molinette, Turin, Italy
Search for more papers by this authorHoward C. Thomas
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorCorresponding Author
Dr. Peter Karayiannis
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Department of Medicine, St. Mary's Hospital Medical School, South Wharf Road, London W2 1NY, United Kingdom===Search for more papers by this authorJohn Saldanha
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorJohn Monjardino
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorRobert Goldin
Liver Unit, Department of Pathology, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorJanice Main
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorShashi Luther
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorMark Easton
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorAntonio Ponzetto
Division of Gastroenterology, Ospedale Molinette, Turin, Italy
Search for more papers by this authorHoward C. Thomas
Liver Unit, Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Search for more papers by this authorAbstract
To assess the role of immunization against hepatitis delta antigen in the prevention of hepatitis delta virus infection, woodchuck carriers of woodchuck hepatitis virus were immunized with a 64 amino acid portion of hepatitis delta antigen from its N-terminal region. The protein was expressed in Escherichia coli and contained a major immunogenic epitope. A significant anti-hepatitis delta response was observed that did not, however, protect the animals from hepatitis delta virus superinfection. Unexpectedly, the period of detectable viremia was longer in the immunized than in the control animals. We conclude that immunization with this recombinant hepatitis delta antigen does not afford protection against subsequent hepatitis delta virus exposure. (HEPATOLOGY 1990;12:1125–1128).
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