The fluidity of liver plasma membranes from patients with different types of liver injury
Amador Schuller
Lipid-Atherosclerosis Unit, Department of Internal Medicine, Hospital Clinico, Spain
Gastroenterology Unit, Hospital 1° de Octubre, Universidad Complutense, 28040 Madrid, Spain
Department of Biochemistry, Universidad Complutense, 28040 Madrid, Spain
Search for more papers by this authorJosé A. Solis-Herruzo
Lipid-Atherosclerosis Unit, Department of Internal Medicine, Hospital Clinico, Spain
Gastroenterology Unit, Hospital 1° de Octubre, Universidad Complutense, 28040 Madrid, Spain
Department of Biochemistry, Universidad Complutense, 28040 Madrid, Spain
Search for more papers by this authorCorresponding Author
Jorge Moscat Ph.D.
Lipid-Atherosclerosis Unit, Department of Internal Medicine, Hospital Clinico, Spain
Gastroenterology Unit, Hospital 1° de Octubre, Universidad Complutense, 28040 Madrid, Spain
Department of Biochemistry, Universidad Complutense, 28040 Madrid, Spain
Pabellon de Medicina y Cirugia Experimental, Hospital Provincial, C/Dr. Esquerdo 46, 28007 Madrid, Spain===Search for more papers by this authorJ. C. Fernandez-Checa
Lipid-Atherosclerosis Unit, Department of Internal Medicine, Hospital Clinico, Spain
Gastroenterology Unit, Hospital 1° de Octubre, Universidad Complutense, 28040 Madrid, Spain
Department of Biochemistry, Universidad Complutense, 28040 Madrid, Spain
Search for more papers by this authorAngel M. Municio
Lipid-Atherosclerosis Unit, Department of Internal Medicine, Hospital Clinico, Spain
Gastroenterology Unit, Hospital 1° de Octubre, Universidad Complutense, 28040 Madrid, Spain
Department of Biochemistry, Universidad Complutense, 28040 Madrid, Spain
Search for more papers by this authorAmador Schuller
Lipid-Atherosclerosis Unit, Department of Internal Medicine, Hospital Clinico, Spain
Gastroenterology Unit, Hospital 1° de Octubre, Universidad Complutense, 28040 Madrid, Spain
Department of Biochemistry, Universidad Complutense, 28040 Madrid, Spain
Search for more papers by this authorJosé A. Solis-Herruzo
Lipid-Atherosclerosis Unit, Department of Internal Medicine, Hospital Clinico, Spain
Gastroenterology Unit, Hospital 1° de Octubre, Universidad Complutense, 28040 Madrid, Spain
Department of Biochemistry, Universidad Complutense, 28040 Madrid, Spain
Search for more papers by this authorCorresponding Author
Jorge Moscat Ph.D.
Lipid-Atherosclerosis Unit, Department of Internal Medicine, Hospital Clinico, Spain
Gastroenterology Unit, Hospital 1° de Octubre, Universidad Complutense, 28040 Madrid, Spain
Department of Biochemistry, Universidad Complutense, 28040 Madrid, Spain
Pabellon de Medicina y Cirugia Experimental, Hospital Provincial, C/Dr. Esquerdo 46, 28007 Madrid, Spain===Search for more papers by this authorJ. C. Fernandez-Checa
Lipid-Atherosclerosis Unit, Department of Internal Medicine, Hospital Clinico, Spain
Gastroenterology Unit, Hospital 1° de Octubre, Universidad Complutense, 28040 Madrid, Spain
Department of Biochemistry, Universidad Complutense, 28040 Madrid, Spain
Search for more papers by this authorAngel M. Municio
Lipid-Atherosclerosis Unit, Department of Internal Medicine, Hospital Clinico, Spain
Gastroenterology Unit, Hospital 1° de Octubre, Universidad Complutense, 28040 Madrid, Spain
Department of Biochemistry, Universidad Complutense, 28040 Madrid, Spain
Search for more papers by this authorAbstract
The physical properties of cell membranes play an important role in cellular homeostasis. Previous studies with animal models have shown that the hepatocyte membrane fluidity has important effects in cellular function. In order to further investigate the relationship between physical properties of membranes and liver disease, the present study was performed. Twenty-nine patients with different degrees of liver injury and 10 control individuals were studied. A lower membrane fluidity–as assessed by diphenylhexatriene fluorescence polarization–was observed in membrane preparations from patients, as compared to controls. These alterations are positively correlated with the severity of liver damage and could be accounted for by a higher cholesterol content of patients' membrane preparations.
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