Nuclear Particles of Non-A, Non-B Type in Healthy Volunteers and Patients with Hepatitis B
Corresponding Author
Hanspeter Spichtin
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Hanspeter Spichtin, M.D., Department of Pathology, University of Basel, Schonbeinstrasse 40, CH-4003 Basel, Switzerland.===Search for more papers by this authorFred Gudat
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorHans Berthold
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorGunthild Krey
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorMartin Schmid
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorMauro Pirovino
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorJosef Altorfer
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorGeorg Stalder
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorGerald Eder
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorLeonardo Bianchi
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorCorresponding Author
Hanspeter Spichtin
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Hanspeter Spichtin, M.D., Department of Pathology, University of Basel, Schonbeinstrasse 40, CH-4003 Basel, Switzerland.===Search for more papers by this authorFred Gudat
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorHans Berthold
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorGunthild Krey
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorMartin Schmid
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorMauro Pirovino
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorJosef Altorfer
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorGeorg Stalder
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorGerald Eder
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorLeonardo Bianchi
Departments of Pathology and Internal Medicine, University of Basel, Basel, Switzerland; Department of Internal Medicine, City Hospital Waid, Zurich, Switzerland; Institute for Virology, Center for Hygiene, Freiburg i.Br., West Germany; and Immuno AG, Vienna, Austria
Search for more papers by this authorAbstract
In an electron microscopic study, nuclear aggregates of virus-like spherical and tubular particles measuring 20 to 29 nm in diameter were found in 5 of 7 clinically healthy volunteers with normal liver histology, 6 of 10 patients with hepatitis B and 17 of 18 patients with hepatitis non-A, non-B. The incidence of hepatocytes containing nuclear particles was approximately 0.5 to 2% in all three groups. We conclude that these nuclear particles are not specific ultrastructural markers of hepatitis non-A, non-B in man as originally claimed for experimental hepatitis non-A, non-B in chimpanzees.
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