The prognostic significance of race in nasopharyngeal carcinoma by histological subtype
Katelyn O. Stepan MD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorAngela L. Mazul PhD, MPH
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Division of Public Health Sciences, Department of Surgery, Washington University, St Louis, Missouri, USA
Search for more papers by this authorS. Andrew Skillington MD, MSCI
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorRandal C. Paniello MD, PhD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorJason T. Rich MD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorJose P. Zevallos MD, MPH
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorRyan S. Jackson MD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorPatrik Pipkorn MD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorSean Massa MD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorCorresponding Author
Sidharth V. Puram MD, PhD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Department of Genetics, Washington University School of Medicine, St Louis, Missouri, USA
Correspondence
Sidharth V. Puram, Department of Otolaryngology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8115, St. Louis, MO 63119, USA.
Email:
Search for more papers by this authorKatelyn O. Stepan MD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorAngela L. Mazul PhD, MPH
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Division of Public Health Sciences, Department of Surgery, Washington University, St Louis, Missouri, USA
Search for more papers by this authorS. Andrew Skillington MD, MSCI
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorRandal C. Paniello MD, PhD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorJason T. Rich MD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorJose P. Zevallos MD, MPH
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorRyan S. Jackson MD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorPatrik Pipkorn MD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorSean Massa MD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Search for more papers by this authorCorresponding Author
Sidharth V. Puram MD, PhD
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
Department of Genetics, Washington University School of Medicine, St Louis, Missouri, USA
Correspondence
Sidharth V. Puram, Department of Otolaryngology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8115, St. Louis, MO 63119, USA.
Email:
Search for more papers by this authorKatelyn O. Stepan and Angela L. Mazul contributed equally to this study.
Section Editor: Benjamin Judson
Funding information: National Institute of Minority Health and Health Disparities, Grant/Award Number: K01MD013897
Abstract
Background
Race has been shown to have variable prognostic importance in nasopharyngeal carcinoma (NPC). However, previous studies are limited by a lack of comprehensive treatment, epidemiologic, and comorbidity data.
Methods
This was a retrospective cohort study utilizing the National Cancer Database from 2004 to 2016. Multivariable Cox proportional hazards regressions were used to calculate adjusted hazard ratios (aHR) for overall survival.
Results
A cohort of 9995 patients met inclusion and exclusion criteria. Race, insurance, comorbidity, treatment, stage, age, and histology were independent prognosticators. Among patients with keratinizing NPC, Asians and Hispanics had superior survival (aHR 0.58 [95% confidence interval (CI) 0.48–0.69], aHR 0.76 [95% CI 0.61–0.96]) compared to white patients. Among patients with non-keratinizing differentiated NPC, Asians and black patients had improved survival (aHR 0.71 [95% CI 0.56–0.91], aHR 0.72 [95% CI 0.54–0.95]) compared to white patients. Race was not prognostic in non-keratinizing undifferentiated NPC.
Conclusion
The prognostic significance of race varies across histological subtypes of NPC.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the National Cancer Database. Restrictions apply to the availability of these data, which were used under license for this study. Data are available from the authors with the permission of the National Cancer Database.
Supporting Information
| Filename | Description |
|---|---|
| hed26639-sup-0001-Tables.docxWord 2007 document , 41.2 KB | Table S1. Characteristics of the cohort stratified by histological subtype. Table S2. Characteristics of the cohort stratified by race. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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