Tina Dalianis, Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden.

Email: [email protected]

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Linnea Haeggblom MSci,

Linnea Haeggblom MSci

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

Linnea Haeggblom, Tove Attoff, Anders Näsman, and Tina Dalianis contributed equally to this work.Search for more papers by this author

Tove Attoff BSci,

Tove Attoff BSci

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

Linnea Haeggblom, Tove Attoff, Anders Näsman, and Tina Dalianis contributed equally to this work.Search for more papers by this author

Jingru Yu MSci,

Jingru Yu MSci

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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Stefan Holzhauser MSci,

Stefan Holzhauser MSci

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Andrea Vlastos MD, PhD,

Andrea Vlastos MD, PhD

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Leila Mirzae MSci,

Leila Mirzae MSci

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Andreas Ährlund-Richter MSci,

Andreas Ährlund-Richter MSci

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Eva Munck-Wikland MD, PhD,

Eva Munck-Wikland MD, PhD

CLINTEC, Karolinska Institutet, Stockholm, Sweden

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Linda Marklund MD, PhD,

Linda Marklund MD, PhD

CLINTEC, Karolinska Institutet, Stockholm, Sweden

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Lalle Hammarstedt-Nordenvall MD, PhD,

Lalle Hammarstedt-Nordenvall MD, PhD

CLINTEC, Karolinska Institutet, Stockholm, Sweden

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Weimin Ye MD, PhD,

Weimin Ye MD, PhD

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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Torbjörn Ramqvist PhD,

Torbjörn Ramqvist PhD

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Anders Näsman MD, PhD,

Anders Näsman MD, PhD

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

Department of Clinical Pathology, Karolinska University Hospital, Stockholm, Sweden

Linnea Haeggblom, Tove Attoff, Anders Näsman, and Tina Dalianis contributed equally to this work.Search for more papers by this author

Tina Dalianis MD, PhD,

Corresponding Author

Tina Dalianis MD, PhD

[email protected]

orcid.org/0000-0001-7022-2424

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

Correspondence

Tina Dalianis, Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden.

Email: [email protected]

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First published: 24 December 2018

https://doi.org/10.1002/hed.25585

Citations: 62

Funding information Cancerfonden, Grant/Award Number: 160259; Karolinska Institutet; The Stockholm Cancer Society, Grant/Award Number: 151053; The Stockholm City Council, Grant/Award Number: 570177; The Swedish Cancer and Allergy Foundation, Grant/Award Number: 73

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Abstract

Background

Tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) has increased. In Stockholm, the proportion of human papillomavirus (HPV)-positive cases and the incidence of TSCC rose between 1970 and 2006 then stabilized. Here, HPV-prevalence, and TSCC/BOTSCC incidence 2000-2016, in Stockholm and Sweden were followed.

Methods

Incidence data for 2000-2016 were obtained from the Swedish Cancer Registry. TSCC/BOTSCC biopsies, 2013-2016 from Stockholm, were examined for HPV DNA and p16^INK4a, or data obtained from medical reports. For cases 2000-2012, data were available from previous studies.

Results

The incidence of TSCC/BOTSCC has continued to rise in Stockholm and Sweden 2000-2016, especially after 2008. HPV DNA and p16^INK4a analysis was determined for 795 Stockholm cases from 2000 to 2016, with 72% being HPV DNA and p16^INK4a positive 2013-2016, and 70% positive 2000-2016.

Conclusion

During 2000-2016, especially after 2008, the incidence of TSCC/BOTSCC has continued to increase in Stockholm and Sweden, with an HPV-prevalence of approximately 70% in Stockholm.

CONFLICT OF INTEREST

None.

Supporting Information

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Citing Literature

Volume41, Issue6

June 2019

Pages 1583-1590

Filename	Description
hed-25585-sup-0001-FigureS1.docxWord 2007 document , 97.1 KB	Supplementary Figure 1 Age-standardized incidence rates of tonsillar squamous cell carcinoma in the Stockholm region for patients with (A) HPV DNA positive and HPV DNA negative tumors and (B) p16 overexpressing tumors and none p16 overexpressing tumors
hed-25585-sup-0002-FigureS2.docxWord 2007 document , 93.6 KB	Supplementary Figure 2 Age-standardized incidence rates of base of tongue squamous cell carcinoma in the Stockholm region for patients with (A) HPV DNA positive and HPV DNA negative tumors and (B) p16 overexpressing tumors and none p16 overexpressing tumors
hed-25585-sup-0001-TableS1.docxWord 2007 document , 47.7 KB	Supplementary Table 1 Number of TSCC and BOTSCC cases and HPV prevalence in Stockholm/Gotland for females and males

Changes in incidence and prevalence of human papillomavirus in tonsillar and base of tongue cancer during 2000-2016 in the Stockholm region and Sweden

Abstract

Background

Methods

Results

Conclusion

CONFLICT OF INTEREST

Supporting Information

REFERENCES

Citing Literature

References

Information

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Changes in incidence and prevalence of human papillomavirus in tonsillar and base of tongue cancer during 2000-2016 in the Stockholm region and Sweden

Abstract

Background

Methods

Results

Conclusion

CONFLICT OF INTEREST

Supporting Information

REFERENCES

Citing Literature

References

Related

Information