Transoral laser microsurgery for treatment for hypopharyngeal cancer in 211 patients
Corresponding Author
Bernhard G. Weiss MD
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Göttingen, Germany
Correspondence Bernhard G. Weiss, Department of Otorhinolaryngology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany Email: [email protected]; Martin Canis, Department of Otorhinolaryngology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany Email: [email protected]Search for more papers by this authorFriedrich Ihler MD
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Göttingen, Germany
Search for more papers by this authorHendrik A. Wolff MD
University Medical Center Göttingen, Göttingen, Germany
Search for more papers by this authorSimon Schneider PhD
Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany
Search for more papers by this authorCorresponding Author
Martin Canis MD
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Göttingen, Germany
Correspondence Bernhard G. Weiss, Department of Otorhinolaryngology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany Email: [email protected]; Martin Canis, Department of Otorhinolaryngology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany Email: [email protected]Search for more papers by this authorWolfgang Steiner MD
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Göttingen, Germany
Search for more papers by this authorChristian Welz MD
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Göttingen, Germany
Search for more papers by this authorCorresponding Author
Bernhard G. Weiss MD
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Göttingen, Germany
Correspondence Bernhard G. Weiss, Department of Otorhinolaryngology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany Email: [email protected]; Martin Canis, Department of Otorhinolaryngology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany Email: [email protected]Search for more papers by this authorFriedrich Ihler MD
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Göttingen, Germany
Search for more papers by this authorHendrik A. Wolff MD
University Medical Center Göttingen, Göttingen, Germany
Search for more papers by this authorSimon Schneider PhD
Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany
Search for more papers by this authorCorresponding Author
Martin Canis MD
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Göttingen, Germany
Correspondence Bernhard G. Weiss, Department of Otorhinolaryngology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany Email: [email protected]; Martin Canis, Department of Otorhinolaryngology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany Email: [email protected]Search for more papers by this authorWolfgang Steiner MD
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Göttingen, Germany
Search for more papers by this authorChristian Welz MD
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Göttingen, Germany
Search for more papers by this authorAbstract
Background
The oncologic and functional outcome of transoral laser microsurgery (TLM) for primary treatment of hypopharyngeal cancer was examined in a multimodal treatment concept.
Methods
Two hundred eleven patients with squamous cell carcinoma (SCC) of the hypopharynx (pT1-4a, pN0-2, M0) were treated by TLM +/− neck dissection (88%) +/− (chemo)radiotherapy ([C]RT; 51%). The majority of cases were advanced stages III and IVa (85%).
Results
The 5-year Kaplan-Meier estimates for local control after TLM were pT category-related 88.1%, 74.8%, 77.3%, and 61.8% for pT1-4a tumors. The 5-year estimates of overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) for early stages I and II were 68.2%, 96.7%, and 74.6%, respectively; for stage III they were 65.9%, 83.8%, and 56.4%, respectively; and the rates for stage IVa were 44.5%, 60.7%, and 50.3%, respectively. Overall, 95.7% of the patients maintained regular oral nutrition without feeding tube dependency.
Conclusion
Primary TLM in multimodal concepts of treatment (+/− neck dissection, +/− [C]RT) offers favorable oncologic results as compared with other therapeutic regimes.
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