Relationship between iodine levels and papillary thyroid carcinoma: A systematic review and meta-analysis
Joon-Hyop Lee MD
Department of Surgery, Seoul National University Bundang Hospital, 300 Gumi-dong Bundang-gu, Seongnam-si, Gyeonggi-do, Korea
Thyroid and Endocrine Surgery Section, Department of Surgery, Gachon University Gil Medical Center, Incheon, Republic of Korea
Search for more papers by this authorYunji Hwang PhD
Department of Preventive Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Search for more papers by this authorRa-Yeong Song MD
Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Search for more papers by this authorJin Wook Yi MD
Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Search for more papers by this authorHyeong Won Yu MD
Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Search for more papers by this authorSu-jin Kim MD, PhD
Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Search for more papers by this authorYoung Jun Chai MD
Department of Surgery, Seoul National University Hospital Boramae Medical Center, Seoul, Korea
Search for more papers by this authorJune Young Choi MD
Department of Surgery, Seoul National University Bundang Hospital, 300 Gumi-dong Bundang-gu, Seongnam-si, Gyeonggi-do, Korea
Search for more papers by this authorCorresponding Author
Kyu Eun Lee MD, PhD
Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Correspondence Kyu Eun Lee, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea., Email: [email protected]Search for more papers by this authorSue K. Park MD, PhD
Department of Preventive Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Search for more papers by this authorJoon-Hyop Lee MD
Department of Surgery, Seoul National University Bundang Hospital, 300 Gumi-dong Bundang-gu, Seongnam-si, Gyeonggi-do, Korea
Thyroid and Endocrine Surgery Section, Department of Surgery, Gachon University Gil Medical Center, Incheon, Republic of Korea
Search for more papers by this authorYunji Hwang PhD
Department of Preventive Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Search for more papers by this authorRa-Yeong Song MD
Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Search for more papers by this authorJin Wook Yi MD
Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Search for more papers by this authorHyeong Won Yu MD
Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Search for more papers by this authorSu-jin Kim MD, PhD
Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Search for more papers by this authorYoung Jun Chai MD
Department of Surgery, Seoul National University Hospital Boramae Medical Center, Seoul, Korea
Search for more papers by this authorJune Young Choi MD
Department of Surgery, Seoul National University Bundang Hospital, 300 Gumi-dong Bundang-gu, Seongnam-si, Gyeonggi-do, Korea
Search for more papers by this authorCorresponding Author
Kyu Eun Lee MD, PhD
Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Correspondence Kyu Eun Lee, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea., Email: [email protected]Search for more papers by this authorSue K. Park MD, PhD
Department of Preventive Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Search for more papers by this authorFunding information: This article was supported by the SNUH Research grant (no. 23-2015-0060, 2015-0277) and the Korean Foundation for Cancer Research grant (No. CB-2011-03-01).
Abstract
Background
Iodine excess has been suggested as an exogenous risk factor of papillary thyroid cancer (PTC). We performed a systematic review and meta-analysis to assess the relationship between iodine exposure measured in various forms and PTC prevalence.
Methods
We searched MEDLINE, Embase, and the Cochrane Library for case-control studies on iodine and PTC published up to December 2015. Exposure to iodine was compared between PTC and control groups.
Results
From the 16 selected studies, the odds ratio (OR) for the overall effect size between high iodine exposure and PTC risk was 1.418 (95% confidence interval [CI] 1.054-1.909). Based on 7 studies conducted in high iodinated regions, a positive association between iodine exposure and PTC was observed (OR 2.200; 95% CI 1.389-3.483).
Conclusion
This study demonstrated a higher exposure to iodine in patients with PTC compared with controls, especially for patients from high iodinated regions.
Supporting Information
Additional Supporting Information may be found online in the supporting information tab for this article.
| Filename | Description |
|---|---|
| hed24797-sup-0001-suppinfo.tiff322.9 KB | Supporting Information Figure S1. Sensitivity analysis of the 16 selected studies. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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