Local resectability assessment of head and neck cancer: Positron emission tomography/MRI versus positron emission tomography/CT
Corresponding Author
Tetsuro Sekine MD, PhD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Department of Radiology, Nippon Medical School, Tokyo, Japan
Correspondence Tetsuro Sekine, Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.Email: [email protected]Search for more papers by this authorFelipe de Galiza Barbosa MD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorGaspar Delso PhD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
GE Healthcare, Waukesha, Wisconsin
Search for more papers by this authorIrene A. Burger MD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorPaul Stolzmann MD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorEdwin E. ter Voert MS
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorGerhard F. Huber MD
Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorSpyros S. Kollias MD
Clinic of Neuroradiology, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorGustav K. von Schulthess MD, PhD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorPatrick Veit-Haibach MD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Institute of Diagnostic and Interventional Radiology, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorMartin W. Huellner MD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorCorresponding Author
Tetsuro Sekine MD, PhD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Department of Radiology, Nippon Medical School, Tokyo, Japan
Correspondence Tetsuro Sekine, Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.Email: [email protected]Search for more papers by this authorFelipe de Galiza Barbosa MD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorGaspar Delso PhD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
GE Healthcare, Waukesha, Wisconsin
Search for more papers by this authorIrene A. Burger MD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorPaul Stolzmann MD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorEdwin E. ter Voert MS
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorGerhard F. Huber MD
Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorSpyros S. Kollias MD
Clinic of Neuroradiology, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorGustav K. von Schulthess MD, PhD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorPatrick Veit-Haibach MD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Institute of Diagnostic and Interventional Radiology, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorMartin W. Huellner MD
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Zurich, Switzerland
Search for more papers by this authorFunding information: This study was funded by GE Healthcare, Waukesha, Wisconsin.
Abstract
Background
The purpose of this study was to compare the diagnostic accuracy of positron emission tomography (PET)/MRI with PET/CT for local resectability of head and neck cancer.
Methods
Sequential contrast-enhanced PET/CT-MRI was performed in 58 patients referred for the staging or restaging of head and neck cancer. Tumors were assessed with PET/CT and PET/MRI for the presence of resectability-defining factors: T4b status (mediastinal invasion, invasion of the prevertebral space, and vascular encasement), and another 8 findings that would imply obstacles for surgical cure (invasion of the laryngeal cartilage, invasion of the preepiglottic fat pad, perineural spread, orbital invasion, bone infiltration, skull base invasion, dural infiltration, and invasion of the brachial plexus).
Results
The sensitivity/specificity/accuracy of local resectability-defining factors of PET/CT and PET/MRI was 0.92/0.99/0.98 and 0.98/0.99/0.99 (P = .727), respectively, per lesion, and 0.96/0.87/0.91 and 0.96/0.90/0.93 (P = .687), respectively, per patient.
Conclusion
Both contrast-enhanced PET/MRI and contrast-enhanced PET/CT can serve as reliable examinations for defining local resectability of head and neck cancer.
Supporting Information
Additional Supporting Information may be found online in the supporting information tab for this article.
| Filename | Description |
|---|---|
| hed24783-sup-0001-suppinfo01.docx470.9 KB | Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
- 1Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011; 61(2): 69–90.
- 2Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010; 17(6): 1471–1474.
- 3Yousem DM, Gad K, Tufano RP. Resectability issues with head and neck cancer. AJNR Am J Neuroradiol. 2006; 27(10): 2024–2036.
- 4Chang PC, Fischbein NJ, McCalmont TH, et al. Perineural spread of malignant melanoma of the head and neck: clinical and imaging features. AJNR Am J Neuroradiol. 2004; 25(1): 5–11.
- 5Kapoor V, Fukui MB, McCook BM. Role of 18FFDG PET/CT in the treatment of head and neck cancers: posttherapy evaluation and pitfalls. AJR Am J Roentgenol. 2005; 184(2): 589–597.
- 6Müller J, Hüllner M, Strobel K, Huber GF, Burger IA, Haerle SK. The value of (18) F-FDG-PET/CT imaging in oral cavity cancer patients following surgical reconstruction. Laryngoscope. 2015; 125(8): 1861–1868.
- 7Rasch C, Keus R, Pameijer FA, et al. The potential impact of CT-MRI matching on tumor volume delineation in advanced head and neck cancer. Int J Radiat Oncol Biol Phys. 1997; 39(4): 841–848.
- 8Sakata K, Hareyama M, Tamakawa M, et al. Prognostic factors of nasopharynx tumors investigated by MR imaging and the value of MR imaging in the newly published TNM staging. Int J Radiat Oncol Biol Phys. 1999; 43(2): 273–278.
- 9Mukherji SK, Wolf GT. Evaluation of head and neck squamous cell carcinoma after treatment. AJNR Am J Neuroradiol. 2003; 24(9): 1743–1746.
- 10Delso G, Fürst S, Jakoby B, et al. Performance measurements of the Siemens mMR integrated whole-body PET/MR scanner. J Nucl Med. 2011; 52(12): 1914–1922.
- 11Partovi S, Kohan A, Vercher-Conejero JL, et al. Qualitative and quantitative performance of 18F-FDG-PET/MRI versus 18F-FDG-PET/CT in patients with head and neck cancer. AJNR Am J Neuroradiol. 2014; 35(10): 1970–1975.
- 12Platzek I, Beuthien-Baumann B, Schneider M, et al. FDG PET/MR for lymph node staging in head and neck cancer. Eur J Radiol. 2014; 83(7): 1163–1168.
- 13Varoquaux A, Rager O, Poncet A, et al. Detection and quantification of focal uptake in head and neck tumours: (18)F-FDG PET/MR versus PET/CT. Eur J Nucl Med Mol Imaging. 2014; 41(3): 462–475.
- 14Queiroz MA, Hüllner M, Kuhn F, et al. Use of diffusion-weighted imaging (DWI) in PET/MRI for head and neck cancer evaluation. Eur J Nucl Med Mol Imaging. 2014; 41(12): 2212–2221.
- 15Kuhn FP, Hüllner M, Mader CE, et al. Contrast-enhanced PET/MR imaging versus contrast-enhanced PET/CT in head and neck cancer: how much MR information is needed? J Nucl Med. 2014; 55(4): 551–558.
- 16Queiroz MA, Hüllner M, Kuhn F, et al. PET/MRI and PET/CT in follow-up of head and neck cancer patients. Eur J Nucl Med Mol Imaging. 2014; 41(6): 1066–1075.
- 17Queiroz MA, Huellner MW. PET/MR in cancers of the head and neck. Semin Nucl Med. 2015; 45(3): 248–265.
- 18Xiao Y, Chen Y, Shi Y, Wu Z. The value of fluorine-18 fluorodeoxyglucose PET/MRI in the diagnosis of head and neck carcinoma: a meta-analysis. Nucl Med Commun. 2015; 36(4): 312–318.
- 19Sekine T, De Galiza Barbosa F, Burger I, et al. Staging of head and neck cancer with PET/MR and PET/CT - initial results. J Nucl Med. 2015; 56(Suppl 3): 70.
- 20Veit-Haibach P, Kuhn FP, Wiesinger F, Delso G, von Schulthess G. PET-MR imaging using a tri-modality PET/CT-MR system with a dedicated shuttle in clinical routine. MAGMA. 2013; 26(1): 25–35.
- 21Roman BR, Goldenberg D, Givi B, Education Committee of American Head and Neck Society (AHNS). AHNS Series—Do you know your guidelines? Guideline recommended follow-up and surveillance of head and neck cancer survivors. Head Neck. 2016; 38(2): 168–174.
- 22Hsu WC, Loevner LA, Karpati R, et al. Accuracy of magnetic resonance imaging in predicting absence of fixation of head and neck cancer to the prevertebral space. Head Neck. 2005; 27(2): 95–100.
- 23Huellner MW, Kuhn FP, Curtin HD. FDG-PET/CT and FDG-PET/MR imaging in head and neck cancer. In: von GK Schulthess, ed. Clinical Molecular Anatomic Imaging: PET/CT, PET/MR and SPECT CT. 3rd ed. Philadelphia, PA: LWW; 2015.
- 24Kuno H, Onaya H, Fujii S, Ojiri H, Otani K, Satake M. Primary staging of laryngeal and hypopharyngeal cancer: CT, MR imaging and dual-energy CT. Eur J Radiol. 2014; 83(1): e23–e35.
- 25Zbären P, Caversaccio M, Thoeny HC, Nuyens M, Curschmann J, Stauffer E. Radionecrosis or tumor recurrence after radiation of laryngeal and hypopharyngeal carcinomas. Otolaryngol Head Neck Surg. 2006; 135(6): 838–843.
- 26Fichandler CE, Farghaly HI, Bumpous JM. Assessing the prevalence and implications of fungal colonization in chondroradionecrosis of the larynx. Laryngoscope. 2011; 121(Suppl S5): S277.
10.1002/lary.22233 Google Scholar
- 27Paes FM, Singer AD, Checkver AN, Palmquist RA, De La Vega G, Sidani C. Perineural spread in head and neck malignancies: clinical significance and evaluation with 18F-FDG PET/CT. Radiographics. 2013; 33(6): 1717–1736.
- 28Frunza A, Slavescu D, Lascar I. Perineural invasion in head and neck cancers - a review. J Med Life. 2014; 7(2): 121–123.
- 29Abd El-Hafez YG, Chen CC, Ng SH, et al. Comparison of PET/CT and MRI for the detection of bone marrow invasion in patients with squamous cell carcinoma of the oral cavity. Oral Oncol. 2011; 47(4): 288–295.
- 30Wiesinger F, Sacolick LI, Menini A, et al. Zero TE MR bone imaging in the head. Magn Reson Med. 2016; 75(1): 107–114.
- 31Delso G, Carl M, Wiesinger F, et al. Anatomic evaluation of 3-dimensional ultrashort-echo-time bone maps for PET/MR attenuation correction. J Nucl Med. 2014; 55(5): 780–785.
- 32Shah JP, Patel SG, Singh B, Shah JP. Jatin Shah's head and neck surgery and oncology. 4th ed. Philadelphia, PA: Elsevier/Mosby; 2012.
- 33Manzoor NF, Russell JO, Bricker A, et al. Impact of surgical resection on survival in patients with advanced head and neck cancer involving the carotid artery. JAMA Otolaryngol Head Neck Surg. 2013; 139(11): 1219–1225.
- 34Yu Q, Wang P, Shi H, Luo J. Carotid artery and jugular vein invasion of oral-maxillofacial and neck malignant tumors: diagnostic value of computed tomography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 96(3): 368–372.
- 35Loevner LA, Yousem DM, Montone KT, Weber R, Chalian AA, Weinstein GS. Can radiologists accurately predict preepiglottic space invasion with MR imaging? AJR Am J Roentgenol. 1997; 169(6): 1681–1687.
Citing Literature
