Original Article

Assessment of the new nodal classification for cutaneous squamous cell carcinoma and its effect on patient stratification

Corresponding Author

Markus Brunner MD

Sydney Head and Neck Cancer Institute, The Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales, Sydney, Australia

Department of Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria, Europe

Corresponding author: M. Brunner, Sydney Head and Neck Cancer Institute, The Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales, 2050, Sydney, Australia. E-mail: [email protected]Search for more papers by this author

Beverly C. Ng MBBS (Hons),

Beverly C. Ng MBBS (Hons)

Sydney Head and Neck Cancer Institute, The Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales, Sydney, Australia

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Michael J. Veness MMed, MD,

Michael J. Veness MMed, MD

Head and Neck Cancer Service, Westmead Hospital, University of Sydney, Sydney, Australia

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Jonathan R. Clark MBBS (Hons), MBiostat,

Jonathan R. Clark MBBS (Hons), MBiostat

Sydney Head and Neck Cancer Institute, The Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales, Sydney, Australia

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Markus Brunner MD,

Corresponding Author

Markus Brunner MD

Sydney Head and Neck Cancer Institute, The Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales, Sydney, Australia

Department of Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria, Europe

Beverly C. Ng MBBS (Hons),

Beverly C. Ng MBBS (Hons)

Sydney Head and Neck Cancer Institute, The Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales, Sydney, Australia

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Michael J. Veness MMed, MD,

Michael J. Veness MMed, MD

Head and Neck Cancer Service, Westmead Hospital, University of Sydney, Sydney, Australia

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Jonathan R. Clark MBBS (Hons), MBiostat,

Jonathan R. Clark MBBS (Hons), MBiostat

Sydney Head and Neck Cancer Institute, The Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales, Sydney, Australia

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First published: 10 January 2014

https://doi.org/10.1002/hed.23602

Citations: 22

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ABSTRACT

Background

The American Joint Committee on Cancer (AJCC) substantially changed the staging of cutaneous squamous cell carcinoma (SCC) in the seventh edition of its staging manual. Although the system is well established in mucosal SCC, very little data are available on its prognostic value in cutaneous SCC.

Methods

We conducted a multivariable analysis of 672 patients with metastatic cutaneous SCC from 2 prospective cancer center databases.

Results

The differentiation between N1 and N2 subgroups demonstrate little prognostic importance in cutaneous SCC, whereas survival is significantly worse for N3.

Conclusion

Although the introduction of a unified N system for mucosal SCC and cutaneous SCC has added complexity, it does not translate into optimal distribution and stratification for metastatic cutaneous SCC. © 2014 Wiley Periodicals, Inc. Head Neck 37: 336–339, 2015

REFERENCES

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Volume37, Issue3

March 2015

Pages 336-339

Assessment of the new nodal classification for cutaneous squamous cell carcinoma and its effect on patient stratification

ABSTRACT

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

Information

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Assessment of the new nodal classification for cutaneous squamous cell carcinoma and its effect on patient stratification

ABSTRACT

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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